A5078232264- RNA and protein synthesis mechanisms
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- RNA Research and Splicing
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- PI3K/AKT/mTOR signaling in cancer
- Oral Health Pathology and Treatment
- Microtubule and mitosis dynamics
- Rheumatoid Arthritis Research and Therapies
- TGF-β signaling in diseases
- Circular RNAs in diseases
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
The First Affiliated Hospital, Sun Yat-sen University
2018-2025
Sun Yat-sen University
2018-2025
Shanghai Ninth People's Hospital
2025
Shanghai Jiao Tong University
2025
Chinese PLA General Hospital
2023-2024
Abstract Background Periodontal ligament stem cells (PDLSCs) are the ideal seed for periodontal tissue regeneration. It is well established that persistent inflammation significantly impairs osteogenic differentiation capability of PDLSCs. Therefore, maintaining PDLSC potential under inflammatory microenvironment important treating bone loss in periodontitis. The aim our study was to explore role circular RNA BIRC6 (circBIRC6) regulating PDLSCs conditions. Methods Alkaline phosphatase...
Cisplatin resistance poses a substantial hurdle in effectively treating head and neck squamous cell carcinoma (HNSCC). Utilizing multiple tumor models examining an internal HNSCC cohort, squalene epoxidase (SQLE) is pinpointed as key driver of chemoresistance tumorigenesis, operating through cholesterol-dependent pathway. Comprehensive transcriptomic analysis reveals that SQLE essential for maintaining c-Myc transcriptional activity by stabilizing the protein averting its ubiquitin-mediated...
Abstract Ribosomal RNA (rRNA) modifications, essential components of ribosome structure and function, significantly impact cellular proteomics cancer biology. These chemical modifications transcend structural roles, critically shaping functionality influencing protein profiles. In this review, the mechanisms by which rRNA regulate both functions broader physiological processes are discussed. Importantly, altering translational output, can shift equilibrium towards oncogenesis, thus playing a...
BACKGROUND:The association of periodontitis (PD) with the prevalence rheumatoid arthritis (RA) remains controversial. Therefore, aim this study was to evaluate their correlation and investigate effects non-surgical periodontal treatment on RA. MATERIAL AND METHODS:A total 64 patients were enrolled in divided into 4 groups: 18 PD (PD+RA–), RA (PD–RA+), (PD+RA+), 10 healthy controls (PD–RA–). Periodontal rheumatologic parameters examined at baseline 1 month following treatment. RESULTS:Our...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent malignancies worldwide characterized by unfavorable prognosis, high lymph node metastasis early recurrence. However, molecular events regulating HNSCC tumorigenesis remain poorly understood. Therefore, uncovering underlying mechanisms urgently needed to identify novel promising therapeutic targets for HNSCC. In this study, we aimed explore role pleckstrin‐2 (PLEK2) in tumorigenesis. Methods The...
Effective control of mesenchymal stem cell (MSC) differentiation towards osteogenic lineages is fundamental for bone regeneration. This study elucidates the regulatory role methyltransferase like 7A (METTL7A) in MSCs. Alkaline phosphatase staining, Alizarin Red S western blotting, and vivo studies were conducted to determine effects METTL7A depletion or overexpression on various types Then downstream signalling pathways regulated by MSCs further investigated. Our findings indicate that...
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors globally. Understanding molecular basis tumor progression drug resistance can offer innovative strategies to enhance clinical outcomes for HNSCC patients. The cytoskeletal remodeling genes associated with cisplatin were screened using a PCR array. role alpha-actinin 1 (ACTN1) in modulating tumorigenesis was evaluated both vitro vivo. Co-immunoprecipitation (Co-IP), IP-mass spectrometry (MS), western...
Aim: This study seeks to develop a prognostic risk signature for head and neck squamous cell carcinoma (HNSCC) based on cholesterol-related genes (CholRG), aiming enhance accuracy in clinical practice. Background: HNSCC poses significant challenges due its aggressive behavior limited response standard treatments, resulting elevated morbidity mortality rates.In order improve prediction HNSCC, our is inspired by the realization that cholesterol metabolism plays critical role accelerating...
Patients with relapsed/refractory classical Hodgkin lymphoma (cHL) achieve complete response (CR) after decitabine-plus-camrelizumab therapy, while long-term outcome especially treatment discontinuation remains unclear. We present a retrospective analysis of 87 cHL patients who acquired CR decitabine-plus-camrelizumab. were divided into two groups and received consolidation every 3-4 or 6-12 weeks, 1-year continuous was guaranteed for cessation. At median follow-up 5.3 years, the...