A5032546252- CAR-T cell therapy research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Neural Networks and Reservoir Computing
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Sensor Technology and Measurement Systems
- Periodontal Regeneration and Treatments
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and disorders
- Hippo pathway signaling and YAP/TAZ
- Advanced Measurement and Detection Methods
- Electrospun Nanofibers in Biomedical Applications
- Traditional Chinese Medicine Analysis
- ATP Synthase and ATPases Research
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Nanoparticle-Based Drug Delivery
Southern Medical University
2021-2025
Affiliated Hospital of Shandong Academy of Medical Sciences
2024
Shandong First Medical University
2024
Nanjing Medical University
2021
Beijing University of Posts and Telecommunications
2010
Hubei University of Science and Technology
2007
Xianning Central Hospital
2007
Abstract The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression efficacy of immunotherapy. This review comprehensively discusses key factors regulating ECM remodeling, including activation cancer-associated fibroblasts accumulation crosslinking proteins. Furthermore, it provides detailed exploration how influences behaviors both immune cells. Significantly, impact on response to various...
Abstract Ribosomal RNA (rRNA) modifications, essential components of ribosome structure and function, significantly impact cellular proteomics cancer biology. These chemical modifications transcend structural roles, critically shaping functionality influencing protein profiles. In this review, the mechanisms by which rRNA regulate both functions broader physiological processes are discussed. Importantly, altering translational output, can shift equilibrium towards oncogenesis, thus playing a...
Abstract Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as hub oxidative metabolism where sugars, fats, and amino acids are ultimately oxidized to release energy. This crucial function fuels variety cellular activities. Disruption mitochondrial is common feature many diseases, including cancer, neurodegenerative conditions cardiovascular diseases. Targeting tumor cell with multifunctional nanosystems emerges promising strategy for enhancing...
Effective control of mesenchymal stem cell (MSC) differentiation towards osteogenic lineages is fundamental for bone regeneration. This study elucidates the regulatory role methyltransferase like 7A (METTL7A) in MSCs. Alkaline phosphatase staining, Alizarin Red S western blotting, and vivo studies were conducted to determine effects METTL7A depletion or overexpression on various types Then downstream signalling pathways regulated by MSCs further investigated. Our findings indicate that...
This paper reports on an experiment about a novel method of polarization stabilization. The stabilizer proposed here has additional function transformation from any state into others. particle swarm optimization is introduced as control algorithm in the process either searching or endless tracking. tracking speed obtained up to 12.6 krad/s by using hardware we have laboratory, which means that can achieve higher practical if faster hardware.
Aim: This study seeks to develop a prognostic risk signature for head and neck squamous cell carcinoma (HNSCC) based on cholesterol-related genes (CholRG), aiming enhance accuracy in clinical practice. Background: HNSCC poses significant challenges due its aggressive behavior limited response standard treatments, resulting elevated morbidity mortality rates.In order improve prediction HNSCC, our is inspired by the realization that cholesterol metabolism plays critical role accelerating...
Mesenchymal stem cells (MSCs) can differentiate into multiple cell lines, which makes them an important source of for tissue engineering applications. They are defined by the capability to renew themselves and maintain pluripotency. This ability is modulated balance between complex cues from cellular microenvironment. Self-renewal differentiation abilities regulated particular microenvironmental signals. Oxygen considered be part microenvironment, not only acts as a metabolic substrate but...