A5101853690- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Genetic factors in colorectal cancer
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Vestibular and auditory disorders
- Plant Stress Responses and Tolerance
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Circular RNAs in diseases
- Urinary and Genital Oncology Studies
- Immune cells in cancer
- Chromosomal and Genetic Variations
- Neurogenetic and Muscular Disorders Research
- Photosynthetic Processes and Mechanisms
- Plant responses to water stress
- Connexins and lens biology
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
Chinese Academy of Sciences
2020-2025
Zhejiang Cancer Hospital
2020-2025
Hangzhou Cancer Hospital
2025
Institute of Acoustics
2023-2024
Fudan University
2020-2024
Huashan Hospital
2020-2024
Qilu Hospital of Shandong University
2023-2024
Northwest A&F University
2024
Ministry of Agriculture and Rural Affairs
2024
Wenzhou Medical University
2013-2023
Significance Lung cancer is the most prevalent and deadly worldwide. Minimally invasive testing for early detection of lung key improving prognosis. In this study, we carried out a multicenter, multiethnic study to compare serum miRNA profiles between 744 NSCLC 944 healthy controls. We discovered 35 candidate biomarkers, verified 22 them, panel 5 miRNAs was optimized stage with AUC > 0.90 in three independent validation cohorts. The sensitivity specificity five-miR I were 83.0% 90.7%,...
ABSTRACT OBJECTIVE To investigate the dynamics of viral RNA, IgM, and IgG their relationships in patients with SARS-CoV-2 pneumonia over an 8-week period. DESIGN Retrospective, observational case series. SETTING Wenzhou Sixth People’s Hospital PARTICIPANTS Thirty-three laboratory confirmed admitted to hospital. Data were collected from January 27 April 10, 2020. MAIN OUTCOME MEASURES Throat swabs, sputum, stool, blood samples collected, load was measured by reverse transcription PCR...
Abstract M6A methylation is likely to be closely associated with the occurrence and development of tumours. In this study, we demonstrated that transcription levels m6A RNA regulators are related prognosis glioma. Univariate Cox analysis was performed on expression selected three hub genes in Next, systematically compared these gliomas different clinicopathological features. The overall survival (OS) curve initially established based TCGA database information. YTHDF1 from following analysis....
The effective treatment and prognosis prediction of bladder cancer (BLCA) remains a medical problem. Ferroptosis is an iron-dependent form programmed cell death. closely related to tumour occurrence progression, but the prognostic value ferroptosis-related genes (FRGs) in BLCA be further clarified. In this study, we identified FRG signature with potential for patients BLCA.The corresponding clinical data mRNA expression profiles were downloaded from Cancer Genome Atlas (TCGA). Univariate Cox...
Abstract Head neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors which ranks sixth incidence in world. Although treatments for HNSCC have improved significantly recent years, its recurrence rate and mortality remain high. Myosin genes been studied a variety tumors, however role has not elucidated. GSE58911 GSE30784 gene expression profile analysis were performed to detect dys-regulated myosin HNSCC. The Cancer Genome Atlas (TCGA) database was used verify study...
Objectives Develop risk-adapted conditional biopsy pathways utilizing MRI in combination with prostate-specific antigen (PSA) density (PSAD) and the ratio of free to total PSA (f/tPSA), respectively, enhance detection clinically significant prostate cancer (csPCa) while minimizing 'negative' biopsies low-risk patients.
Sudden unexplained death (SUD) refers to sudden in which the cause of could not be established after a comprehensive medico-legal investigation, including pathological/toxicological assessment and forensic investigation circumstances death. In past decade, molecular autopsy has proved an efficient diagnostic tool multidisciplinary management SUD. Though numerous pathogenic/likely pathogenic (P/LP) variants have been identified, there is still large proportion SUD cases without clear...
Abstract Objective To refine the existing CT algorithm to enhance inter-reader agreement and improve diagnostic performance for clear-cell renal cell carcinoma (ccRCC) in solid masses less than 4 cm. Methods A retrospective collection of 331 patients with pathologically confirmed were enrolled this study. Two radiologists independently assessed images: addition heterogeneity score (HS) mass-to-cortex corticomedullary attenuation ratio (MCAR), measured parameters included major diameter minor...
Kinetoplast DNA (kDNA), the mitochondrial of trypanosomatids, consists thousands minicircles and 20 to 30 maxicircles catenated into a single large network exists in cell as highly organized compact disc structure. To investigate role kinetoplast-associated proteins organizing condensing kDNA networks this structure, we have cloned three genes encoding proteins. The KAP2, KAP3, KAP4 encode p18, p17, p16, respectively. These are small basic rich lysine alanine residues contain 9-amino-acid...
Abstract Purpose To determine the postoperative effects of radiotherapy (PORT) on local recurrence‐free survival (LRFS) and overall (OS) stage III‐N2 non‐small‐cell lung cancer (NSCLC). Materials Methods 183 patients with resected III‐pN2 NSCLC from Hunan Cancer Hospital between 2013 2016 were divided into two groups for chemotherapy (POCT) (n = 105) or combination (POCRT) 78). The LRFS OS compared factors affecting recurrence illustrated in these groups. sites failure based lobe primary...
Background: Colon adenocarcinoma (COAD) is a common malignant tumor of the digestive tract with poor clinical outcomes. Cuproptosis novel cell death mechanism and linked to mitochondrial respiration. However, role cuproptosis in colon cancer microenvironment (TME) immune responses remains unknown. Methods: We conducted difference analysis identify differential expressed cuproptosis-related genes (CRGs). According CRGs, TCGA-COAD samples were categorized using consensus clustering. The LASSO...
The incidence of Alzheimer’s disease (AD) has been increasing in the recent years but underlying mechanisms remain uncertain. This study aimed to analyze differentially expressed genes (DEGs) entorhinal cortex with AD and identify featured related AD. Gene expression profile GSE5281 was downloaded from Expression Omnibus, including 10 13 control samples. Differentially were identified by Student t test 119 upregulated 591 downregulated DEGs. Then, we obtained 14 enrichment Kyoto Encyclopedia...
Streptococcus suis (SS) is an important bacterial zoonotic pathogen, which can cause infections in pigs and humans. However, the pathogenesis of this bacterium remains unclear, even though some putative virulence factors (VFs) have been reported. Comparative proteomics could be used to identify markers that distinguish strains with different virulence; however, application method restricted by genome diversities existing strains. In study, two mutants, WT ΔpepT ΔrfeA, were generated from...
Background: Considering the heterogeneity and complexity of epigenetic regulation in bladder cancer, underlying mechanisms global DNA methylation modification immune microenvironment must be investigated to predict prognosis outcomes clinical response immunotherapy. Methods: We systematically assessed modes 985 integrated cancer samples with unsupervised clustering algorithm. Subsequently, these were analyzed for their correlations features microenvironment. The principal analysis algorithm...
Human hypopharygeal squamous cell carcinoma (HSCC) is a common head and neck cancer with poor prognosis in advanced stages. The occurrence development of tumor the result mutual influence co-evolution between cells microenvironment (TME). Tumor immune (TIME) refers to surrounding cells. Studying TIME HSCC could provide new targets therapeutic strategies for HSCC.We performed single-cell RNA sequencing (scRNA-seq) analysis hypopharyngeal carcinoma, paracancerous, lymphoid tissues from five...
Puccinellia tenuiflora is a forage grass with high nutritional value that an extreme alkali-tolerant halophyte: it can survive at pH 10-11. Root secretion perceived as major plant alkali tolerance mechanism. In the present study, we applied widely targeted metabolomic approach to identify and quantify root exudates of P. under stress. We also surveyed transcriptional metabolic profiling roots salt (96-mM Na+ , 6.8) 9.6) stresses reveal biological processes mediating secretion. plants, 493...
Phospholipid phosphatase related 4 (PLPPR4), a neuron-specific membrane protein located at the postsynaptic density of glutamatergic synapses, is putative regulator neuronal plasticity. However, PLPPR4 dysfunction has not been linked to genetic disorders. In this study, we report three unrelated patients with intellectual disability (ID) or autism spectrum disorder (ASD) who harbour de novo heterozygous copy number loss in 1p21.2p21.3, nonsense mutation (NM_014839, c.4C > T, p.Gln2*) and...
Accumulating studies implied that long noncoding RNAs (lncRNAs) act as essential factors in regulating diverse biological behaviors of cancers. Small nucleolar RNA host gene 11 (SNHG11) has been reported for its oncogenic properties several cancer types. However, it is unclear whether SNHG11 exerts functions non-small cell lung (NSCLC) remains unclear. The aim this study was to inspect the role and regulatory mechanism NSCLC. expression NSCLC cells analyzed by qRT-PCR. Functional experiments...