A5100398401- SARS-CoV-2 and COVID-19 Research
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Crystallization and Solubility Studies
- Immunotherapy and Immune Responses
- X-ray Diffraction in Crystallography
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Asthma and respiratory diseases
- HIV Research and Treatment
- MicroRNA in disease regulation
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Inflammatory Bowel Disease
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
Shaanxi Provincial People's Hospital
2014-2025
Anqing Normal University
2025
Cellular Engineering Technologies (United States)
2023-2024
Guangdong Ocean University
2008-2024
Foshan Maternity and Child Health Care Hospital
2018-2024
Southern Medical University
2018-2024
Neijiang Normal University
2024
Massachusetts General Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Imperial College London
2018-2024
BackgroundThe effects that therapies for inflammatory bowel disease (IBD) have on immune responses to SARS-CoV-2 vaccination are not yet fully known. Therefore, we sought determine whether COVID-19 vaccine-induced antibody were altered in patients with IBD commonly used immunosuppressive drugs.MethodsIn this multicentre, prospective, case-control study (VIP), recruited adults treated one of six different treatment regimens (thiopurines, infliximab, a thiopurine plus ustekinumab, vedolizumab,...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.
COVID-19 is a widespread and highly contagious disease in the human population.
Despite the broad-spectrum antimicrobial activities of silver, its internal usage is restricted, owing to toxicity. Strategies enhance efficacy are highly desirable but rely heavily on understanding molecular mechanism action. However, up now, no direct silver-targeting proteins have been mined at a proteome-wide scale, which hinders systemic studies biological pathways interrupted by silver. Herein, we build unique system, namely liquid chromatography gel electrophoresis inductively coupled...
Abstract Itaconic acid is produced by immune responsive gene 1 ( IRG1 )-coded enzyme in activated macrophages and known to play an important role metabolism immunity. In this study, mechanism of itaconic functioning as anti-inflammatory metabolite was investigated with molecular biology immunology techniques, employing -null (prepared CRISPR) wild-type macrophages. Experimental results showed that significantly promoted the pentose phosphate pathway (PPP), which subsequently led higher NADPH...
BackgroundCOVID-19 vaccine-induced antibody responses are reduced in patients with inflammatory bowel disease (IBD) taking anti-TNF or tofacitinib after two vaccine doses. We sought to assess whether immunosuppressive treatments were associated and T-cell IBD a third dose.MethodsVIP was multicentre, prospective, case-control study done nine centres the UK. recruited immunosuppressed non-immunosuppressed healthy individuals. All participants aged 18 years older. The control group had no...
Patients with inflammatory bowel disease (IBD) treated anti-TNF therapy exhibit attenuated humoral immune responses to vaccination against SARS-CoV-2. The gut microbiota and its functional metabolic output, which are perturbed in IBD, play an important role shaping host responses. We explored whether the metabolome could explain variation anti-SARS-CoV-2 immunosuppressed IBD patients.Faecal serum samples were prospectively collected from infliximab-treated patients CLARITY-IBD study...
Diabetic wound healing is delayed due to persistent inflammation, and macrophage-immunomodulating biomaterials can control the inflammatory phase shorten time. In this study, acellular embryoid bodies (aEBs) were prepared mixed with thermosensitive hydroxybutyl chitosan (HBC) hydrogels produce aEB/HBC composite hydrogels. The exhibited reversible temperature-sensitive transition behavior a hybrid porous network. vitro analysis showed that better antimicrobial activity than PBS control, aEBs...
Oxidative stress plays a significant role in exacerbation of asthma. The vitamin D oxidative and asthma remains unclear. We aimed to determine the relationship between status exacerbation. Severe patients with 25-hydroxyvitamin D3-deficiency (V-D deficiency) or D-sufficiency sufficiency) were enrolled. V-D-deficiency showed lower forced expiratory volume one second (FEV1) compared that V-D-sufficiency. intensified ROS release DNA damage increased TNF-α, OGG1 NFκB expression phosphorylation...
Seneca Valley virus (SVV-001) is a nonpathogenic oncolytic that can be systemically administered and pass through the blood-brain barrier. We examined its therapeutic efficacy mechanism of tumor cell infection in pediatric malignant gliomas.In vitro antitumor activities were primary cultures, preformed neurospheres, self-renewing glioma cells derived from 6 patient orthotopic xenograft mouse models (1 anaplastic astrocytoma 5 GBM). In vivo was by systemic treatment xenografts 3 permissive 2...
Tumor engineering is defined as the construction of three-dimensional (3D) tumors in vitro with tissue approaches. The present 3D scaffolds for tumor have several limitations terms structure and function. To get an ideal scaffold culture, A549 human pulmonary adenocarcinoma cells were implanted into immunodeficient mice to establish xenotransplatation models. Tumors retrieved at 30-day implantation sliced sheets. They subsequently decellularized by four procedures. Two decellularization...
The most important indoor allergens for humans are house dust mites (HDM). Fourteen Dermatophagoides farinae (Der f 1–3, 6, 7, 10, 11, 13–18, and 22) reported although more than 30 have been estimated in D. farinae. Seventeen belonging to 12 different groups were identified by a procedure of proteomics combined with two-dimensional immunoblotting from farina extracts. Their sequences determined Edman degradation, mass spectrometry analysis, cDNA cloning. allergenicities assayed enzyme-linked...
Osmotic stress is a widespread phenomenon in aquatic animal. The ability to cope with salinity and alkaline quite important for the survival of species under natural conditions. Tilapia an commercial euryhaline fish species. What's more tilapia good experimental material osmotic regulation research, but molecular mechanism underlying different pressure still unexplored.To elucidate osmoregulation strategy behind its hyper salinity, alkalinity salinity-alkalinity tilapia, transcriptomes gills...
Abstract Accumulated evidence has suggested that microRNAs (miRNAs) have an important role in tumor development and progression by regulating diverse signaling pathways. However, the precise of miRNAs gastric cancer (GC) not been elucidated. In this study, we describe function regulation network miR-491-5p GC. is frequently downregulated GC tissues compared with adjacent non-cancerous tissues. Forced expression significantly inhibits proliferation colony formation, promotes apoptosis cells....
Systemic inflammatory response has been implicated as a contributor to the onset of febrile seizures (FS). The four novel indices such as, neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), count (PLT) and red blood cell distribution width (RDW) have investigated in FS susceptibility types (simple seizure complex seizure). However, potential role these markers MPV/PLT (MPR) Chinese children with yet be fully determined. This study relevance NLR, MPV, PLT, MPR RDW without...
Gender is a significant risk factor for late-onset Alzheimer's disease (AD), often attributed to the decline of estrogen. The plant estrogen secoisolariciresinol diglucoside (SDG) has demonstrated anti-inflammatory and neuroprotective effects. However, protective effects mechanisms SDG in female AD remain unclear. Ten-month-old APPswe/PSEN1dE9 (APP/PS1) transgenic mice were treated with assess its potential ameliorative on cognitive impairments model through series behavioral biochemical...
Clear cell renal carcinoma (ccRCC) is the most common subtype of kidney cancer with a high metastatic rate and mortality rate. The molecular mechanism ccRCC development, however, needs further study. Aurora kinase B (AURKB) functions as an important oncogene in various tumors; therefore, present study, we aimed to explore by which AURKB affects development. We performed bioinformatics analysis, CCK-8 assay, RNA sequencing, RT-PCR Western blot analyze function ccRCC. TIMER2.0 showed that was...