A5029142767- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Platelet Disorders and Treatments
- Cancer-related Molecular Pathways
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- Bioactive Compounds and Antitumor Agents
- Protein Degradation and Inhibitors
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Yersinia bacterium, plague, ectoparasites research
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Medical Image Segmentation Techniques
- Blood disorders and treatments
Fujian Provincial Cancer Hospital
2025
Fujian Medical University
2025
Chongqing Medical University
2023-2025
Dalian Medical University
2014-2025
China Pharmaceutical University
2025
Zhejiang Cancer Hospital
2015-2024
Xiamen University
2024
Wuhan University
2023-2024
University of Chinese Academy of Sciences
2019-2024
Chinese Academy of Sciences
2016-2024
Abstract MALAT1, one of the few highly conserved nuclear long noncoding RNAs (lncRNAs), is abundantly expressed in normal tissues. Previously, targeted inactivation and genetic rescue experiments identified MALAT1 as a suppressor breast cancer lung metastasis. On other hand, Malat1-knockout mice are viable develop normally. quest to discover fundamental roles physiological pathological processes, we find that this lncRNA downregulated during osteoclastogenesis humans mice. Remarkably, Malat1...
The mean survival of metastatic lung adenocarcinoma is less than 1 year, highlighting the urgent need to understand mechanisms underlying its high mortality rate. role Extracellular vesicles (EVs) in facilitating interactions between cancer cells and microenvironment has garnered increasing attention. Previous studies on EVs metastasis have been primarily focused cell-derived modulating functions stromal cells. However, whether stem (CSCs) can alter properties non-CSC cells, EV crosstalk...
Cytochrome P450 2J2 (CYP2J2), a key enzyme responsible for oxidative metabolism of various xenobiotics and endogenous compounds, participates in diverse array physiological pathological processes humans. Its biological role tumorigenesis cancer diagnosis remains poorly understood, owing to the lack molecular tools suitable real-time monitoring CYP2J2 complex systems. Using design principles, we were able modify distance between catalytic unit metabolic recognition moiety, allowing us develop...
Abstract There has been a dramatic increase in the detection of lung nodules, many which are preneoplasia atypical adenomatous hyperplasia (AAH), adenocarcinoma situ (AIS), minimally invasive (MIA) or (ADC). The molecular landscape and evolutionary trajectory have not well defined. Here, we perform multi-region exome sequencing 116 resected nodules including AAH (n = 22), AIS 27), MIA 54) synchronous ADC 13). Comparing to AIS, ADC, observe progressive genomic evolution at single nucleotide...
The multi‑kinase inhibitor sorafenib is the only drug for which randomized control trials have shown improved patient survival in advanced hepatocellular carcinoma (HCC). However, life expectancy extended these cases by a few months. anti‑type II diabetes agent metformin was used this study an effort to find more efficient approach HCC treatment. Sorafenib effectively reversed activation status of mTORC2 induced and enhanced suppression mTORC1 MAPK pathway cells, may be responsible reduced...
Significance Lung cancer is the most prevalent and deadly worldwide. Minimally invasive testing for early detection of lung key improving prognosis. In this study, we carried out a multicenter, multiethnic study to compare serum miRNA profiles between 744 NSCLC 944 healthy controls. We discovered 35 candidate biomarkers, verified 22 them, panel 5 miRNAs was optimized stage with AUC > 0.90 in three independent validation cohorts. The sensitivity specificity five-miR I were 83.0% 90.7%,...
Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia miltiorrhiza, has well-known antioxidant anti-inflammatory actions. We aimed to evaluate ability SalB protect against APAP-induced hepatotoxicity by inducing nuclear factor-erythroid-2-related factor 2 (Nrf2) expression. pretreatment ameliorated...
Septins are a novel class of GTP-binding cytoskeletal proteins evolutionarily conserved from yeast to mammals and have now been found play contributing role in broad range tumor types. However, their functional importance breast cancer remains largely unclear. Here, we demonstrated that pharmaceutical inhibition global septin dynamics would greatly suppress proliferation, migration invasiveness cell lines. We then examined the expression subcellular distribution selected septins SEPT2 SEPT7...
Abstract Background Exosomes are a new class of molecular entities in the metastatic microenvironment, which can mediate bidirectional communication between cells. While exosomes-mediated interactions tumor cells and other cell populations microenvironment have attracted most attention, little is known about significance exosomes mediating interaction non-stemness cancer stem during progression. Methods The structure, sequence downstream target miRNAs lncRNA Mir100hg were predicted by online...
Altered branched chain amino acids (BCAAs), including leucine, isoleucine, and valine, are frequently observed in patients with advanced cancer. We evaluated the efficacy of chimeric antigen receptor (CAR) T cell-mediated cancer cell lysis potential immune microenvironment BCAA supplementation deletion. increased killing percentage, while accelerating catabolism decreasing transporter decreased efficacy. thus designed BCKDK engineering CAR cells for reprogramming metabolism tumor based on...
<title>Abstract</title> <bold>Background: </bold>Endometrial injury, particularly intrauterine adhesions (Asherman’s syndrome), represents a prevalent condition that significantly compromises female fertility. Current clinical interventions predominantly involve hysteroscopic surgery, followed by the placement of barriers and administration oral estrogen to facilitate endometrial regeneration. Nevertheless, in patients with severe adhesions, postoperative pregnancy rates remain low, ranging...
// Ning Tang 1, * , Lei Shi 2, Zhenlong Yu 4, Peipei Dong 1 Chao Wang Xiaokui Huo Baojing Zhang Shanshan Huang Sa Deng Kexin Liu Tonghui Ma 3 Xiaobo 4 Lijun Wu Xiao-Chi College of Pharmacy, Academy Integrative Medicine, Key Laboratory Pharmacokinetic and Drug Transport Liaoning, Dalian Medical University, Dalian, China 2 Institute Cancer Stem Cell, Basic Science, Department Pharmacy Traditional Chinese medicine, People’s Liberation Army 210 Hospital, These authors have contributed...
Acute megakaryoblastic leukemia (AMKL) is a rare hematological malignancy in adults but children. Alternative splicing (AS) has been shown to affect cancer progression, making factors promising targets. Our research aims investigate the efficacy of molecular glue degrader indisulam, which targets factor RNA binding motif protein 39 (RBM39) AMKL models. Public drug sensitivity data analysis revealed that cell lines exhibited highest indisulam compared with other tumor types. Then we confirmed...
Rheumatoid arthritis (RA) is a progressive autoimmune disease affecting the joints. In this study, we investigated role of pro-angiogenic factor leptin in regulating reactive oxygen species (ROS) to promote cell migration and angiogenesis RA. We showed that triggered RA fibroblast-like synoviocyte (FLS) by increased ROS expression. Additionally, enhanced human umbilical vein endothelial (HUVEC) tube formation ROS/hypoxia-inducible factor-1α-dependent manner, accompanied production vascular...