A5100385435- Oral microbiology and periodontitis research
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Microbial Natural Products and Biosynthesis
- Breast Cancer Treatment Studies
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- RNA modifications and cancer
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
- Power Systems Fault Detection
- HVDC Systems and Fault Protection
- Cancer Immunotherapy and Biomarkers
- High-Voltage Power Transmission Systems
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Cholesterol and Lipid Metabolism
- Bone Tissue Engineering Materials
- Respiratory viral infections research
- Estrogen and related hormone effects
- Colorectal Cancer Screening and Detection
- Advanced biosensing and bioanalysis techniques
- Cancer Mechanisms and Therapy
Sichuan University
2020-2025
Qingdao University
2023-2025
Shanxi Medical University
2022-2025
Shaanxi University of Chinese Medicine
2023-2025
Mission Health
2025
Anhui Medical University
2025
South China Normal University
2025
University of California, Los Angeles
2025
Tianjin Medical University
2025
Tianjin University
2025
Precise assembly of semiconductor heterojunctions is the key to realize many optoelectronic devices. By exploiting strong and tunable van der Waals (vdW) forces between graphene organic small molecules, we demonstrate layer-by-layer epitaxy ultrathin semiconductors heterostructures with unprecedented precision well-defined number layers self-limited characteristics. We further p–n molecularly flat interface, which exhibit excellent rectifying behavior photovoltaic responses. The molecular...
Abstract Acute myocardial infarction (AMI), the leading cause of mortality worldwide, is a rapidly developing and irreversible disease. Therefore, proper prompt intervention at early stage AMI crucial for its treatment. However, molecular features in have not been clarified. Here, we constructed mouse model profiled transcriptomes proteomes stages progress. Immune system was extensively activated 6-h AMI. Then, pyroptosis 24-h VX-765 treatment, inhibitor, significantly reduced infarct size...
More recently, NCAPG2 has emerged as an intrinsically essential participant of the condensin II complex involved in process chromosome cohesion and stabilization mitosis, its position particular tumours is now being highlighted. Simultaneously, genetic properties hint that it might have enormous potential to interpret malignant progression tumors a broader perspective, is, pan-cancer. Yet, at present, this recognition remains merely superficial there lack more detailed studies explore...
Salvia miltiorrhiza Bunge (Labiatae) (DS) is a key part of the traditional Chinese medicine, whose roots are used to remove blood stasis, relieve pain, eliminate carbuncle and calm nerves. Our research team found that DS extract could significantly reverse LPS-induced lung injury, five new diterpenoid quinones in with excellent protective activity for first time. However, material basis mechanism on pulmonary fibrosis (PF) needs be explored depth. Bleomycin (BLM) was employed establish PF...
Diabetic neuropathic pain (DNP) is a common complication of diabetes mellitus (DM) and characterized by spontaneous neuroinflammation. The Sigma-1 receptor (Sig-1R) has been proposed as target for analgesic development. It an important with anti-inflammatory properties found to regulate DNP. However, it not known whether Sig-1R can ameliorate pathological neuroinflammation in present study used rat model DNP highly selective agonist assess the effects protein on rats type 2 mellitus. were...
Roughly one third of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-sensitive mutated (EGFRm) tumors experience disease progression through central nervous system (CNS) metastases during treatment. Although EGFR-TKIs have been reported to be favored in some EGFRm NSCLC CNS metastases, novel proven efficacy pathologies are clinically needed.To investigate whether almonertinib, a third-generation EGFR-TKI for NSCLC, can...
Despite the unprecedented advancement of cancer treatment, prognosis for patients with metastatic stage remains poor. The challenge that underlines this clinical dilemma is complexity metastasis. conventional experiment-driven discovery approaches (the “wet lab”) yield overly simplified one-to-one mechanistic relationships are inept elucidating Metastasis research also suffers from knowledge and skill deficiency individual investigators. importance present study demonstration “dry-lab-driven...
Abstract Background Exosomes are a new class of molecular entities in the metastatic microenvironment, which can mediate bidirectional communication between cells. While exosomes-mediated interactions tumor cells and other cell populations microenvironment have attracted most attention, little is known about significance exosomes mediating interaction non-stemness cancer stem during progression. Methods The structure, sequence downstream target miRNAs lncRNA Mir100hg were predicted by online...
Diabetic liver injury (DLI) is one of the complications diabetes mellitus, which seriously jeopardizes human health. Punicalagin (PU), a polyphenolic compound mainly found in pomegranate peel, has been shown to ameliorate metabolic diseases such as DLI, and mechanism needs be further explored. In this study, HFD/STZ-induced diabetic mouse model established investigate effect PU on DLI. The results show that intervention significantly improves histology serum biochemical abnormalities mice,...
Sarcopenia and obesity, two prevalent health conditions, often coexist exacerbate each other's impact, increasing the risk of chronic diseases mortality. This dual condition is termed "sarcopenic obesity." The correlation between oxidative stress (OS) sarcopenia or obesity was established, balance score (OBS) can serve as an indicator overall dietary lifestyle-related OS exposure within individual. Prior reports have not addressed relationship OBS sarcopenic in adults under 60. study...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unknown etiology and limited therapeutic options. Activation of fibroblasts prominent feature fibrosis. Here we report that lncRNA DACH1 (dachshund homolog 1) downregulated in the lungs IPF patients an experimental mouse model lung LncDACH1 knockout mice develop spontaneous fibrosis, whereas overexpression attenuated TGF-β1-induced aberrant activation, collagen deposition differentiation fibroblasts. Similarly, forced...
Pathogens that cause pediatric severe community-acquired pneumonia (SCAP) requiring bronchoscopy intervention are understudied. Through this study, we explore the etiology of SCAP form alveolar lavage fluid (ALF) samples by RespiFinder 2SMART multi-PCR assay.
High levels of cell-free DNA (cfDNA) induce psoriasis. Currently, the treatment psoriasis has disadvantages penetration difficulty, suppression normal immunity, and skin irritation. In this study, biguanide chitosan microneedles (BGC-MNs) were prepared to treat by removing cfDNA from dermis through barrier. The effects with different bisguanidine contents on DNA-binding capacity, biocompatibility, inflammation inhibition compared, revealing that containing 20% (BGC2) was found have best...
The number of young patients diagnosed with breast cancer is on the rise. We studied rate trend local recurrence (LR) and regional (RR) in (YBC) outcomes among these based molecular subtypes.A retrospective cohort study was conducted data from Tianjin Medical University Cancer Institute Hospital for ≤ 35 years age pathologically confirmed primary invasive surgically treated between 2006 2014. Patients were categorized according to subtypes basis hormone receptor (HR) human epidermal growth...