A5100687853- Molecular Sensors and Ion Detection
- Bone Metabolism and Diseases
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Biochemical effects in animals
- Nanoplatforms for cancer theranostics
- Pain Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Chemical Synthesis and Analysis
- Bone health and osteoporosis research
- Pharmacological Effects of Natural Compounds
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Crystallography and molecular interactions
- Computational Drug Discovery Methods
- Sulfur Compounds in Biology
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Analytical Chemistry and Sensors
- Cancer-related Molecular Pathways
- Synthesis and Biological Evaluation
- Cancer, Hypoxia, and Metabolism
- Synthesis and biological activity
Nanchang University
2024-2025
China Pharmaceutical University
2024
Nantong University
2023
Northwest Institute of Mechanical and Electrical Engineering
2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Northwestern Polytechnical University
2013-2022
Anhui University of Technology
2022
Affiliated Hospital of Qingdao University
2021
Qingdao University
2021
Context Diabetic peripheral neuropathy (DPN) results in an enormous burden and reduces the quality of life for patients. Considering there is no specific drug management DPN, traditional Chinese medicine (TCM) has increasingly drawn attention clinicians researchers around world due to its characteristics multiple targets, active components, exemplary safety.
Combined chemotherapy is often affected by the different physicochemical properties of chemotherapeutic drugs, which should be improved reasonable design co-loaded preparations.A kind simple but practical graphene oxide (GO) wrapped mesoporous silica nanoparticles (MSN) modified with hyaluronic acid (MSN@GO-HA) were developed for co-delivery cinnamaldehyde (CA) and doxorubicin (DOX), in order to enhance their combined treatment on tumor cells reduce application defects.The MSNCA@GODOX-HA was...
Osteoporosis treatment always aimed at keeping the balance of bone formation and resorption. Recently, prenyl group in natural products has been proposed as an active to enhance osteogenesis process. Osthole both bone-protective activities, but relationship is still unknown. In this study we found that osthole exerted a potent ability promote proliferation osteogenic function rat marrow stromal cells osteoblasts, including improved cell viability, alkaline phosphatase activity, enhanced...
Radix Dipsaci total saponins (RTS) are primary active components of Dipsaci, which is administered orally for the treatment osteoporosis according to Chinese Medicine. RTS have also been shown reduce risk bone fractures in rats. However, detailed molecular mechanisms underlying their action remain elusive. In present study, ability increase alkaline phosphatase activity, osteocalcin levels and degree mineralization was investigated MC3T3‑E1 mouse osteoblast precursor cells. addition,...
Purpose: The levels of reactive oxygen species (ROS) in tumor cells are much higher than that normal cells, and rise rapidly under the influence exogenous or endogenous inducing factors, eventually leading to apoptosis cells. Therefore, this study prepared a dual pH/reducing-responsive poly ( N -isopropylacrylamide-co-Cinnamaldehyde-co-D-α-tocopheryl polyethylene glycol 1000 succinate, P ss NCT) nanogels, which employed two ROS inducers, cinnamaldehyde (CA) D-α-tocopheryl succinate (TPGS),...
Context: Radix Dipsaci is a kidney tonifying herbal medicine with long history of safe use for treatment bone fractures and joint diseases in China. Previous studies have shown that extract (RDE) could prevent loss ovariectomized rats.
The excessive increase of intracellular reactive oxygen species (ROS) makes tumor cells usually in the state oxidative stress. Although can adapt to this a certain extent by upregulating antioxidant systems, further ROS insults disrupt transient redox balance, eventually leading apoptosis and necrosis. Therefore, increasing level effectively amplify stress induce apoptosis, which be employed as strategy for treatment. Herein, unique pH-responsive inducing micellar system was reported study...
Hypoxia is a major stressor and prominent feature of pathological conditions, such as bacterial infections, inflammation, wounds, cardiovascular defects. In this study, we investigated whether reoxygenation has protective effect against hypoxia-induced acute injury burn using the C57BL/6 mouse model. mice were exposed to hypoxia treated with both injuries in until wound healing. Next, for three days then transferred normoxic conditions Finally, skin tissue was collected analyze...
A simple and unique conjugation of norvancomycin-fluorescein (VanF) has been achieved. It was characterized by UV-vis fluorescence spectra confirmed MALDI-TOF mass spectrum. The photodynamic assay indicated that VanF effectively inactivated the Gram-positive Bacillus subtilis (ATCC 6633) from clinic with inactivation rate 30-70% within 1-7.5 μM. In vitro, showed low antimicrobial activity value >128 μg/mL, binding affinity 180 nM per 10(8) cells/mL against bacteria strains. imaging could...
The anterior cingulate cortex (ACC) serves as a critical hub for the anxiety and pain perception. large-conductance Ca2+-activated potassium channels, or BKCa are ubiquitously expressed throughout central nervous system including cortex. However, what changes of cortical channels undergo in ACC remains unknown pain-related anxiety. In present study, significant upregulation synaptic non-synaptic channel accessory β4 subunits was accompanied with pain-associated anxiety-like behaviors chronic...