A5069772311- Prenatal Screening and Diagnostics
- Pain Mechanisms and Treatments
- Genomic variations and chromosomal abnormalities
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Ion channel regulation and function
- Genomics and Rare Diseases
- SARS-CoV-2 and COVID-19 Research
- Neurogenetic and Muscular Disorders Research
- Tumors and Oncological Cases
- Renal and related cancers
- 3D Printing in Biomedical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Genetic Neurodegenerative Diseases
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Meat and Animal Product Quality
- Long-Term Effects of COVID-19
- Healthcare and Venom Research
- Congenital heart defects research
- Mitochondrial Function and Pathology
- SARS-CoV-2 detection and testing
- Bee Products Chemical Analysis
- Vestibular and auditory disorders
Hubei University of Medicine
2016-2024
Taihe Hospital
2016-2024
Wenzhou Central Hospital
2015-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
China Tobacco Guangxi Industrial (China)
2024
Wenzhou Medical University
2014-2022
Nanjing Medical University
2021
State Key Laboratory of Food Science and Technology
2008-2014
Liaocheng People's Hospital
2014
ABSTRACT OBJECTIVE To investigate the dynamics of viral RNA, IgM, and IgG their relationships in patients with SARS-CoV-2 pneumonia over an 8-week period. DESIGN Retrospective, observational case series. SETTING Wenzhou Sixth People’s Hospital PARTICIPANTS Thirty-three laboratory confirmed admitted to hospital. Data were collected from January 27 April 10, 2020. MAIN OUTCOME MEASURES Throat swabs, sputum, stool, blood samples collected, load was measured by reverse transcription PCR...
Abstract Introduction Facioscapulohumeral muscular dystrophy 1 (FSHD1) is a relatively common autosomal dominant adult with variable disease penetrance. The caused by shortening of D4Z4 repeat array located near the telomere chromosome 4 at 4q35. This causes activation dormant gene DUX4 , permitting aberrant expression which toxic to muscles. Molecular diagnosis FSHD1 Southern blot hybridization or FISH combing difficult and time consuming, requiring specialist laboratories. As an...
Abstract Leveraging physical factors in cellular microenvironments to promote adipose tissue-derived stem cell (ADSC) osteogenic differentiation has emerged as a new strategy the development of scaffolds for bone tissue engineering. Anisotropicity is one those interest; however, utilization anisotropicity ADSC still not efficient. In this study, we designed substrate with dual anisotropic structure fabricated via combination 3D printing and magnetic field-induced nanoparticle assembly...
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity SARS-CoV-2 infection. Here, we found that with long viral RNA course (LC) high-level IgG antibodies and higher regulatory T (Treg) cell counts compared to those short (SC) in terms load. Longitudinal proteomics metabolomics analyses the patient sera uncovered shedding was associated inhibition liver X receptor/retinoid receptor (LXR/RXR) pathway, substantial suppression diverse metabolites, activation...
Effect of cooking temperature (40–100°C) on changes in protein composition big head carp muscle and exudate was investigated. The results showed that the proportion salt-soluble water-soluble proteins cooked decreased with up to 50°C 60°C, respectively. Alkali-soluble content increased increasing range 40–98°C, while both non-protein nitrogen (NPN) alkali- insoluble no significant change. Content soluble collagen exudates temperature. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis...
Genetic skeletal disorders (GSD) involving the system arises through disturbances in complex processes of development, growth and homeostasis remain a diagnostic challenge because their clinical heterogeneity genetic variety. Over past decades, tremendous effort platforms have been made to explore heterogeneity, massive new genes mutations identified different GSD, but information supplied by literature is still limited it hard meet further needs scientists clinicians. In this study,...
Phospholipid phosphatase related 4 (PLPPR4), a neuron-specific membrane protein located at the postsynaptic density of glutamatergic synapses, is putative regulator neuronal plasticity. However, PLPPR4 dysfunction has not been linked to genetic disorders. In this study, we report three unrelated patients with intellectual disability (ID) or autism spectrum disorder (ASD) who harbour de novo heterozygous copy number loss in 1p21.2p21.3, nonsense mutation (NM_014839, c.4C > T, p.Gln2*) and...
The cultivation system requires that the approach providing biomass for all types of metabolic analysis is excellent quality and reliability. This study was conducted to enhance efficiency yield antifungal substance (AFS) production in Streptomyces yanglinensis 3–10 by optimizing operation conditions aeration, agitation, carbon source, incubation time a fermenter. Dissolved oxygen (DO) pH were found play significant roles AFS production. optimum S. be 6.5. As synthesis generally thought an...
Neuronal network reconstruction is a pivotal determinant for functional recovery after spinal cord injury (SCI), the process of which includes synaptogenesis. Slit2 protein has been identified as key regulator axon regeneration and synapse formation in vertebrate. Meanwhile, RhoA converging cascade inhibitory molecules that interrupt synaptic plasticity SCI. In present study, we investigated interaction among Slit2, Robo1, potential roles pathological We showed was decreased, whereas Robo1...
Abstract Background Cleidocranial dysplasia (CCD) is a dominantly inherited disease characterized by hypoplastic or absent clavicles, large fontanels, dental dysplasia, and delayed skeletal development. The purpose of this study to investigate the genetic basis Chinese family with CCD. Methods Here, CCD hyperplastic nails was recruited. clinical features displayed significant intrafamilial variation. We sequenced coding region RUNX2 gene for mutation phenotype analysis. Results carries...
Abstract Background Hearing loss (HL) is a common sensory disorder in humans characterized by extreme clinical and genetic heterogeneity. In recent years, next‐generation sequencing (NGS) technologies have proven to be highly effective powerful tools for population studies of HL. Here, we analyzed molecular data from 21 Chinese deaf families who did not hotspot mutations the deafness genes GJB2 , SLC26A4 GJB3 MT ‐ RNR1 . Method Targeted (TGS) 127 known was performed probands 12 families,...
Cancer induced bone pain is a very complicated clinical states that has proven difficult to be treated effectively due poorly understand of underlying mechanism, but cancer (BCP) seems enhanced by state spinal sensitization. In the present study, we showed carcinoma tibia implantation notable sensitization and up-regulation G-protein-coupled estrogen receptor (GPR30) in cord rats which was reversed GPR30 knockdown. Further studies indicated upregulation resulted select loss γ-aminobutyric...
Promotion odontogenic differentiation of dental pulp stem cells (DPSCs) is essential for dentin regeneration. Physical cellular microenvironment critical importance and influences the function other biological/chemical factors to differentiation.Based on adjusting mechanical/interfacial properties hydrogels, multicellular spheroids (MCSs) DPSCs generated through self-organization. The were characterized by immunofluorescent staining flow cytometry. Quantitative real-time polymerase chain...
Abstract Total amount of creatine (Cr) and phosphocreatine, or total (tCr), may have a significant impact on the performance skeletal muscles. In sports such as bodybuilding, it is popular to take Cr supplements maintain tCr level. However, no study has explored quantitative relationship between exercise intensity induced change in muscle's tCr. this well‐controlled study, straight‐leg plantar flexion with specific load duration was performed by 10 healthy subjects inside an MRI scanner,...
Abstract Background With the application of chromosome microarray, next-generation sequencing and other highly sensitive genetic techniques in disease diagnosis, detection mosaicism has become increasingly prevalent. This study involved a retrospective analysis SNP array testing on 4512 prenatal diagnosis samples, wherein characterization was explored insights were gained into underlying mechanisms thereof. Results Using array, total 44 cases identified among diagnostic cases; resulting rate...
<b><i>Objectives:</i></b> To evaluate the usefulness of single-nucleotide polymorphism (SNP) array for prenatal genetic diagnosis congenital heart defect (CHD), we used this approach to detect clinically significant copy number variants (CNVs) in fetuses with CHDs. <b><i>Methods:</i></b> A HumanCytoSNP-12 was genomic samples obtained from 39 that exhibited cardiovascular abnormalities on ultrasound and had a normal karyotype. The relationship...