A5000901927- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Circadian rhythm and melatonin
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Pain Mechanisms and Treatments
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Cancer Research and Treatments
- Urological Disorders and Treatments
- Hemoglobin structure and function
- Neurobiology and Insect Physiology Research
- Axon Guidance and Neuronal Signaling
- Multiple and Secondary Primary Cancers
- Radiopharmaceutical Chemistry and Applications
- Airway Management and Intubation Techniques
- Hepatitis B Virus Studies
- Esophageal Cancer Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
Shanghai Jiao Tong University
2014-2025
International Peace Maternity & Child Health Hospital
2015-2024
Shanghai Municipal People's Government
2019-2020
Yahoo (United Kingdom)
2020
First Affiliated Hospital of Anhui Medical University
2014-2020
Anhui Medical University
2014-2020
Air Force Medical University
2020
Xijing Hospital
2020
Nantong University
2020
Anhui Provincial Hospital
2020
<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) is an emerging infectious that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated. <h3>Objective</h3> To describe characteristics patients with who developed acute respiratory distress syndrome (ARDS) or died. <h3>Design, Setting, Participants</h3> Retrospective cohort study 201 confirmed admitted to Wuhan Jinyintan...
ISOFLURANE has shown neuroprotective properties in response to numerous biological stresses vitro 1–5and vivo .6–9However, an increasing number of studies suggest that isoflurane may be neurotoxic 10–13and 14–19as well. Isoflurane causes persistent hippocampal-dependent cognitive deficits rodents,15,16but the mechanisms such are not clear. Neurogenesis hippocampus is involved memory acquisition,20suggesting act on neural progenitor cells (NPCs) impinge functions. Accordingly, emerging into...
Background Dexmedetomidine induces a sedative response that is associated with rapid arousal. To elucidate the underlying mechanisms, authors hypothesized dexmedetomidine increases activity of dopaminergic neurons in ventral tegmental area, and this action contributes to unique properties dexmedetomidine. Methods Only male mice were used. The area dopamine was measured by genetically encoded Ca2+ indicator patch-clamp recording. Dopamine neurotransmitter dynamics medial prefrontal cortex...
To evaluate the antitumor activity of gemcitabine (GEM), cisplatin (DDP) as well combination these two agents in lung cancer cells and mice.The cell viability was evaluated by CCK-8 assay. Cell apoptosis measured flow cytometry assay Hoechst staining. The protein expression VEGF, VEGFR2, Ang II, AT1R, ACE2 examined Western blotting. effect GEM DDP on tumor growth survival time also mice vivo.The results revealed that alone or combined administration could inhibit growth, induce apoptotic...
Intratumoral hypoxia promotes angiogenesis, invasion and epithelial-mesenchymal transition, a pivotal event in tumor metastasis. TWIST is master regulator of multiple developmental processes has recently been shown to be the key factor responsible for cancer metastasis via inhibition E-cadherin expression, hallmark transition. This study aimed determine expression hypoxia-inducible 1α, patients with endometrioid endometrial carcinoma examine their clinical significance progression.Using...
Abstract Increasing studies have demonstrated that sevoflurane can induce neurotoxicity in the developing brains. JNK normally promotes apoptosis. It was hypothesized affected proliferation and differentiation of FNSCs induced cell apoptosis, which caused learning memory deficits via pathway. Sevoflurane at a concentration 1.2% did not damage on FNSC S . However, concentrations 2.4% 4.8% decreased viability, as shown by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)...
The circadian clock is a cell-autonomous time-keeping mechanism established gradually during embryonic development. Here, we generated transgenic zebrafish line carrying destabilized fluorescent protein driven by the promoter of core gene, nr1d1, to report in vivo rhythm at single-cell level. By time-lapse imaging this fish and 3D reconstruction, observed sequential initiation reporter expression starting photoreceptors pineal gland, then spreading cells other brain regions Even within found...
We investigated the effect of propofol on proliferation and viability rat embryonic neural stem cells (rENSCs) potential mechanisms involved.rENSCs were isolated cultured in vitro treated with 1, 10, or 50 µM propofol, while control group was 0.1 dimethyl sulfoxide.The rENSCs examined by apoptosis assays.Real-time polymerase chain reaction employed to analyze mRNA expression checkpoint kinase 1 (Chk1) p53 exposed propofol.Immunoprecipitation assay western blotting analysis performed Chk1...
Circadian clock genes have the function of producing circadian rhythm. They are also implicated in origin or development many diseases such as cancers and neuropsychiatric diseases. The purpose this study is to determine whether 54‐nucleotide repeat polymorphism hPer3 , one genes, associates with heroin dependence. DNA samples were obtained from 209 Chinese heroin‐dependent subjects 249 healthy controls. was detected by polymerase chain reaction agarose gel electrophoresis. frequency...
Hypospadias is one of the most common male congenital malformations worldwide. It characterised by abnormal positioning opening urethra, and may lead to problems with urination sexual function. Various factors were suggested contribute hypospadias pathogen. This study aimed evaluate relationship between perinatal neonatal based on a large sample newborns.This retrospective case-control was conducted at International Peace Maternal Child Health Hospital, Shanghai Jiao Tong University School...