A5100646259- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Organoboron and organosilicon chemistry
- Tendon Structure and Treatment
- Advanced Breast Cancer Therapies
- Synthesis and characterization of novel inorganic/organometallic compounds
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
- Phagocytosis and Immune Regulation
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Shoulder Injury and Treatment
- Cancer-related gene regulation
City Of Hope National Medical Center
2021-2025
Zhejiang University
2006-2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2010-2025
Peking University
2024-2025
City of Hope
2020-2025
The University of Texas at El Paso
2014-2024
Zhengzhou University
2013-2024
Yunnan University of Traditional Chinese Medicine
2021-2024
Linyi University
2020-2024
Henan Provincial Chest Hospital
2024
Tendons are traditionally thought to consist of tenocytes only, the resident cells tendons; however, a recent study has demonstrated that human and mouse tendons also contain stem cells, referred as tendon stem/progenitor (TSCs). However, differential properties TSCs remain largely undefined. This aims characterize these derived from rabbits. were isolated patellar Achilles The differentiation potential cell marker expression two types examined using histochemical, immunohistochemical,...
Platelet-rich plasma (PRP) containing hepatocyte growth factor (HGF) and other factors are widely used in orthopaedic/sports medicine to repair injured tendons. While PRP treatment is reported decrease pain patients with tendon injury, the mechanism of this effect not clear. Tendon often associated inflammation, HGF known protect tissues from inflammatory damages. Therefore, we hypothesized that causes anti-inflammatory effects. To test hypothesis, performed vitro experiments on rabbit cells...
Serum resistance is a poorly understood but common trait of some difficult-to-treat pathogenic strains bacteria. Here, we report that glycine, serine and threonine catabolic pathway down-regulated in serum-resistant Escherichia coli, whereas exogenous glycine reverts the serum effectively potentiates to eliminate clinically-relevant bacterial pathogens vitro vivo. We find increases formation membrane attack complex on through two previously unrecognized regulations: 1) negatively positively...
Angiogenesis is a complex process orchestrated by both growth factors and cell adhesion initiated focal degradation of the vascular basement membrane with subsequent migration proliferation endothelial cells. The Ras/Raf/MEK/ERK pathway required for EC function during angiogenesis. Although in vitro studies implicate ERK1 ERK2 survival, their precise role angiogenesis vivo remains poorly defined. Cre/loxP technology was used to inactivate Erk1 Erk2 cells murine development, resulting...
Mechanical loading constantly acts on tendons, and a better understanding of its effects the tendons is essential to gain more insights into tendon patho-physiology. This study aims investigate mechanobiological responses through use mouse treadmill running as an in vivo model mechanical stretching cells vitro model. In study, mice underwent moderate (MTR) intensive (ITR) regimens. Treadmill elevated expression growth factors (MGF) enhanced proliferative potential stem (TSCs) both patellar...
Targeted inhibition of oncogenic miRNA-21 has been proposed to treat glioblastoma by rescuing tumor suppressors, PTEN and PDCD4. However, systemic delivery anti-miR-21 sequences requires a robust efficient platform successfully inhibit this druggable target. Three-way-junction (3WJ)-based RNA nanoparticles (RNP), artificially derived from pRNA bacteriophage phi29 DNA packaging motor, was recently shown target glioblastoma. Here, we report that multi-valent folate (FA)-conjugated 3WJ RNP...
Senescent cells within the tumor microenvironment (TME) adopt a proinflammatory, senescence-associated secretory phenotype (SASP) that promotes cancer initiation, progression, and therapeutic resistance. Here, exposure to palbociclib (PD-0332991), CDK4/6 inhibitor, induces senescence robust SASP in normal fibroblasts. Senescence caused by prolonged inhibition is DNA damage-independent associated with Mdm2 downregulation, whereas elicited these largely reliant upon NF-κB activation. Based...
Abstract The ability of some animals to rapidly change their colors can greatly improve chances escaping predators or hunting prey. A classic example is cephalopods, which shift through a wide range colors. This based on the synergetic effect pigmentary and structural exhibited by own two categories color‐changing cells: supernatant chromatophores offer various lower iridophores leucophores reflect different adjusting periodicities. Here, mechanochromic liquid crystalline elastomer with...
Abstract With the demand for diversity and security of information deliveries increasing, advanced tag data encryption has attracted great interest from scientific community. It is promising to achieve composite dynamic storage by combination multisource stimuli‐responsive mechanism. Here, mechano‐ chemochromism cholesteric liquid crystal elastomers (CLCEs) are prepared introducing a rhodamine lactam‐based functional trigger two different strategies, one which one‐pot method another...
Cancer patients produce autoantibodies to self-proteins called tumor-associated antigens (TAA). These represent potentially valuable tools for identifying novel biomarkers and therapeutic targets. This study was designed identify TAA in prostate cancer (PCa).Serum the survival protein lens epithelium-derived growth factor p75 (LEDGF/p75) were detected by immunofluorescence microscopy, ELISA, immunoblotting. Expression of LEDGF/p75 cells tumors evaluated immunoblotting or...
Abstract Injection of Dexamethasone (Dex) is commonly used in clinics to treat tendon injury such as tendinopathy because its anti‐inflammatory capabilities. However, serious adverse effects have been reported a result Dex treatment, impaired healing and rupture. Using both vitro vivo approaches, this study was determine the treatment on proliferation differentiation human stem cells (hTSCs), which can directly impact healing. We found that stimulated cell at lower concentrations (<1,000...
Monomeric iminoalane: A donor-stabilized monomeric iminoalane was prepared by the reaction of 1 with an N-heterocyclic carbene (see scheme). The X-ray structure exhibits a very short AlN bond 1.705(4) Å, which suggests multiple-bond character. Treatment phenyl acetylene, aniline, and carbon monoxide resulted in addition reactions to formal AlN bond, thus indicating that multiple is highly reactive. Detailed facts importance specialist readers are published as "Supporting Information". Such...
Tendon–bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and often repaired with scar tissue formation that compromises normal function. This study explored the feasibility using kartogenin (KGN), a biocompound, to enhance healing injured TBJs. We first determined effects KGN on proliferation chondrogenic differentiation rabbit bone marrow stromal cells (BMSCs) patellar tendon stem/progenitor (PTSCs) vitro. enhanced cell both types...
Triple negative breast cancers are a heterogeneous group of tumors characterized by poor patient survival and lack targeted therapeutics. Androgen receptor has been associated with triple cancer pathogenesis, but its role in the different subtypes not clearly defined. We examined androgen protein expression immunohistochemical analysis 678 cancers, including 396 cancers. Fifty matched lymph node metastases were also examined. Association status clinical (race, survival) pathological (basal,...
In spite of standard multimodal therapy consisting surgical resection followed by radiation and concurrent chemotherapy, prognosis for glioblastoma (GBM) patients remains poor. The identification both differentiated undifferentiated "stem cell like" populations in the tumor highlights significance finding novel targets that affect heterogeneous population. Protein arginine methyltransferase 5 (PRMT5) is one such candidate gene whose nuclear expression correlates with poor survival has been...
Hepatitis B virus (HBV) infection remains a major health problem worldwide. The role played by microRNAs (miRNAs) in HBV replication and pathogenesis is being increasingly recognized. In this study, we found that miR-15b, an important miRNA during hepatocellular carcinoma development, directly binds hepatocyte nuclear factor 1α (HNF1α) mRNA, negative regulator of Enhancer I, to attenuate HNF1α expression, resulting transactivation turn causing the enhancement expression antigens, including...
Tissues and organs in vivo are under a hypoxic condition; that is, the oxygen tension is typically much lower than ambient air. However, effects of such condition on tendon stem cells, recently identified cell, remain incompletely defined. In cell culture experiments, we subjected human cells (hTSCs) to with 5% O2, while subjecting control normaxic 20% O2. We found hTSCs at O2 had significantly greater proliferation those Moreover, expression two marker genes, Nanog Oct-4, was upregulated...
Both the proteasome inhibitor bortezomib and an oncolytic herpes simplex virus-1 (oHSV)-expressing GM-CSF are currently FDA approved. Although blockade can increase oHSV replication, immunologic consequences, consequent immunotherapy potential unknown. In this study, we investigated impact of combined with on tumor cell death sensitivity to natural killer (NK) immunotherapy.
Abstract EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin TKI has been previously reported, however, the precise mechanism by which activation contributes to is not clear. Here, we show that inhibition results signaling a Notch3-dependent manner, facilitates survival subset cells call “adaptive persisters”. We reported EGFR-TKI treatment rapidly activates Notch3, and here describe physical...
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The exploration new biomarkers with high sensitivity specificity for early diagnosis AMI therefore becomes one the primary task. In current study, we aim to detect whether there is any heart specific long noncoding RNA (lncRNA) releasing into circulation during AMI, explore its function in neonatal rat cardiac myocytes injury induced by H2O2. Our results revealed that cardiac-specific lncRNA MHRT...
Bortezomib is an FDA-approved proteasome inhibitor, and oncolytic herpes simplex virus-1 (oHSV) a promising therapeutic approach for cancer. We tested the impact of combining bortezomib with oHSV antitumor efficacy.The synergistic interaction between was calculated using Chou-Talalay analysis. Viral replication evaluated plaque assay immune fluorescence. Western blot assays were used to evaluate induction estrogen receptor (ER) stress unfolded protein response (UPR). Inhibitors targeting...