A5090679080- Veterinary Oncology Research
- Cephalopods and Marine Biology
- Neuroendocrine regulation and behavior
- Insect Utilization and Effects
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Veterinary Equine Medical Research
- Microbial infections and disease research
- Virus-based gene therapy research
- Animal health and immunology
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Turtle Biology and Conservation
- Blood properties and coagulation
- Herpesvirus Infections and Treatments
- Veterinary medicine and infectious diseases
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Animal testing and alternatives
- Helminth infection and control
- Aquaculture disease management and microbiota
University of Tennessee at Knoxville
2015-2025
Knoxville College
2025
Cornell University
2009-2021
New York State College of Veterinary Medicine
2009-2021
University of Kentucky
2020
University of California, Davis
2020
John Wiley & Sons (United States)
2019
Hudson Institute
2019
The Ohio State University
2005-2012
Background The majority of published reference intervals for hematology and clinical biochemistry in pigs are generated from a sample group that is demographically different companion pigs, as such may not be transferable. goals this study were to provide sexually mature compare results based on age group, breed, reproductive status. Reference ideally the same laboratory which patient samples measured, since there often bias values instruments, but cost time commitment required produce...
Background Immunophenotyping has replaced cytochemical staining as the preferred technique for classifying acute leukemia. However, some myeloid leukemias ( AML ) lack lineage‐associated markers. In our experience, alkaline phosphatase ALP is expressed in immature canine monocytes. We hypothesized that a useful marker monocytic . Objectives The objective was to compare expression neoplastic cells from dogs with lymphoma, chronic lymphocytic leukemia CLL ), lymphoid ALL and Methods Alkaline...
Hypogammaglobulinemia as a result of failure transfer passive immunity (FTPI) is an important risk factor for infectious disease in neonatal foals. The current gold standard determining serum immunoglobulin concentrations radial immunodiffusion (RID). purpose this study was to compare measured by RID with those determined automated turbidimetric immunoassay (TIA), which has much shorter turnaround time. Immunoglobulin were both and TIA collected from 84 Sixty‐seven foals had results within...
Indices of reticulocyte cell size and hemoglobin content show promise for diagnosing iron deficiency (FeDef), but have not been evaluated in other causes canine anemia or microcytosis.The aims this study were to establish reference intervals (RI) indices dogs, compare results from dogs with FeDef 3 conditions that may mimic on hematologic biochemical testing, including inflammatory disease (AID), portosystemic shunting (PSS), breed-associated microcytosis (BAM).Reticulocyte measured using...
Abstract Dogs have a similar incidence of spontaneous cancers as people, and noninvasive test to monitor disease status in dogs would be great value. Humans with cancer often increased levels cell‐free circulating DNA their plasma, which has shown promise for diagnosis, prognosis detection residual disease. We hypothesized that compared healthy or non‐neoplastic diseases. Plasma was measured 40 dogs, 20 diseases 80 cancer. The reference interval plasma 1–15 ng mL −1 . lymphoma lymphoid...
In binary cell‐fate decisions, driving one lineage and suppressing the other are conjoined. We have previously reported that aryl hydrocarbon receptor (AhR) promotes retinoic acid (RA)‐induced granulocytic differentiation of bipotent HL‐60 myeloblastic leukemia cells. VAF347, an AhR agonist, impairs development CD14 + CD11b monocytes from granulo‐monocytic (GM) stage precursors. thus hypothesized VAF347 propels RA‐induced D 3 ‐induced monocytic Our results show enhanced cell cycle arrest,...
To describe in vivo corneal confocal microscopy of horses with microscopic foreign bodies and to correlate findings clinical, cytological, histopathologic evaluations clinical cases body morphologies observed vitro the microscope.Five bodies.Sedated anesthetized were examined a modified Heidelberg Retina Tomograph II Rostock Cornea Module. Confocal images compared from cytologic samples. establish morphologic features, burdock pappus bristles surgical glove powder obtained by...
Abstract Ultrasonography and radiography are standard diagnostic tests for cats with suspected splenic disease, however published information on outside sources of variation currently lacking. The purpose this prospective, randomized, crossover group study was to evaluate effects common sedative drugs the sonographic radiographic characteristics spleen in healthy cats. Fifteen adult research were randomly assigned into one three groups corresponding different sequences administration five...
Lymphoid leukemia of T-cell origin was diagnosed in a male Chinese Box turtle, Cuora flavomarginata, approximately 25 years age. The turtle presented with history anorexia, open-mouth breathing, and lethargy for one week. CBC findings included mildly increased PCV, severe leukocytosis due to high numbers atypical cells interpreted be blasts. blasts were medium-sized round pleomorphic nuclei, slightly clumped chromatin, indistinct nucleoli, scant moderate-to-dark blue cytoplasm occasional...
Intraarticular (IA) administration of viral vectors expressing a therapeutic transgene is an attractive treatment modality for osteoarthritis (OA) as the joint can be treated contained unit. Humoral and cell-mediated immune responses in vivo limit vector effectiveness. Transduction articular tissues has been investigated; however, response to IA remains largely unknown. We hypothesized that rAAV2 rAAV5 overexpressing insulin-like growth factor-I (IGF-I) would result long-term IGF-I formation...
Abstract Background Mycoplasma haemolamae (Mhl) and gastrointestinal nematodes can cause anemia in camelids. Control programs aim to suppress parasitism without promoting anthelminthic resistance, but few evidence‐based guidelines define acceptable parasite loads Hypothesis/Objectives In clinically healthy nonanemic camelids, compare erythrocyte variables Mhl real‐time PCR status fecal egg count (FEC). Determine the FEC threshold above which are consistently below reference interval medians....
There are few reports in dogs that have evaluated the utility of semi-quantitative scoring bone marrow iron stores conjunction with reticulocyte hemoglobin (CHr) to identify iron-restricted erythropoiesis due absolute deficiency or sequestration.An established system for human samples was applied dogs. The objectives were evaluate interobserver agreement (Κω ), determine scores without detectable hematologic abnormalities, and assess combined interpretation CHr erythropoiesis.Four blinded...
Summary This case report provides a clinical description of an epithelioid variant haemangiosarcoma in horse. Haemangiosarcomas are rare neoplasms equids, and only recently have the pathological aspects horses been described. Despite performance cytology surgical biopsy, ante mortem diagnosis was incorrect this case, demonstrating common problem with diagnosing neoplasm due to lack overt vascular differentiation. Due deteriorating condition patient, no antineoplastic treatment attempted. A...
Abstract: A 17‐year‐old domestic shorthaired cat was presented to the Cornell University Hospital for Animals recheck of hyperthyroidism previously treated with radioiodine. Marked agglutination noted in a blood sample collected into EDTA CBC; no other clinical or hematologic evidence hemolysis observed and none developed despite persistent additional samples over 2‐month period. Blood drawn heparin sodium citrate tubes did not have grossly microscopically detectable agglutination, unless...
Accurate erythrocyte measurements with ADVIA hematology analyzers require isovolumetric cell sphering in one reaction and hemolysis another. However, camelid erythrocytes are resistant to osmotic lysis, no published evaluation of methods for camelids exists.The objectives were demonstrate whether sphere the red blood cell/platelet (RBC/PLT) reagent lyse cyanide HGB reagent, determine optimal settings camelids.Camelid canine diluted 1:625 RBC/PLT evaluated microscopically sphering. A sample...
Ferret systemic coronaviral disease (FSCD) is a well-established cause of mortality in domestic ferrets. We describe herein novel findings case FSCD that was diagnosed and medically managed following virus detection by immunohistochemical (IHC) staining surgical biopsy samples. Hematologic changes this ferret suggested spread the to bone marrow, which confirmed IHC postmortem sample. Genotyping indicated grouped with alphacoronaviruses most closely related enteric coronavirus (FRECV) MSU-2....
Iron-restricted erythropoiesis can occur as a result of an absolute deficiency iron stores, inflammation-mediated sequestration, or functional (in which release stored is slower than the uptake by erythroid precursors during intense erythropoiesis). Reticulocyte indices are used to identify iron-restricted erythropoiesis, with reticulocyte hemoglobin content (CHr) being most commonly index in human patients. Dogs immune-mediated hemolytic anemia (IMHA) may have caused sequestration and/or...
Hypogammaglobulinemia as a result of failure transfer passive immunity (FTPI) is an important risk factor for infectious disease in neonatal foals. The current gold standard determining serum immunoglobulin concentrations radial immunodiffusion (RID). purpose this study was to compare measured by RID with those determined automated turbidimetric immunoassay (TIA), which has much shorter turnaround time. Immunoglobulin were both and TIA collected from 84 Sixty-seven foals had results within...
OBJECTIVE To provide contemporary preliminary guidelines for the morphological evaluation of bone marrow in conjunction with CBC results healthy juvenile (3- to 6-month-old) female New Zealand White rabbits (Oryctolagus cuniculus). ANIMALS 22 rabbits. PROCEDURES Each rabbit was sedated, and a blood sample (3 mL) collected from an ear artery CBC, after which euthanized. Within 5 minutes euthanasia, samples were obtained femur cytologic histologic evaluation. Bone specimens stained modified...
Abstract Histoplasmosis is one of the most common systemic fungal diseases in cats from United States. It commonly causes respiratory or disseminated disease and often associated with more cytopenias. Here, we describe 32 which a Histoplasma ‐like infection was concurrent hemophagia at least sample site, spleen, bone marrow, liver, and/or lymph node. The degree characterized as moderate marked majority cases, all there predominance phagocytized mature erythrocytes. A few cases also had...