A5065921814- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Phytochemical compounds biological activities
- Bone and Dental Protein Studies
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Urinary Tract Infections Management
- Systems Engineering Methodologies and Applications
- Renal and related cancers
- Ferrocene Chemistry and Applications
- Design Education and Practice
- Protein Degradation and Inhibitors
- Urinary Bladder and Prostate Research
- Anthropology: Ethics, History, Culture
- Oral and Maxillofacial Pathology
- Dermatology and Skin Diseases
Palm Beach Atlantic University
2021
United States Army War College
2019
Maharaj Institute of Immune Regenerative Medicine
2019
The Ohio State University
2002-2014
USA Mitchell Cancer Institute
2013
University of South Alabama
2013
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2012
University of Alabama at Birmingham
2010
Duke University Hospital
2010
Wake Forest University
2010
Purpose To evaluate the prognostic significance of expression levels a single microRNA, miR-181a, in context established molecular markers cytogenetically normal acute myeloid leukemia (CN-AML), and to gain insight into leukemogenic role miR-181a. Patients Methods miR-181a was measured pretreatment marrow using Ohio State University Comprehensive Cancer Center version 3.0 arrays 187 younger (< 60 years) adults with CN-AML. Presence other prognosticators assessed centrally. A...
Abstract Background Activating mutations [internal tandem duplication (ITD)] or overexpression of the FMS-like tyrosine kinase receptor-3 ( FLT3 ) gene are associated with poor outcome in acute myeloid leukemia (AML) patients, underscoring need for novel therapeutic approaches. The natural product silvestrol has potent antitumor activity several malignancies, but its impact on distinct molecular high-risk AML subsets remains to be fully investigated. We examined here preclinical -ITD and...
Aberrant expression of the secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in normal tissue remodeling, is associated with variety diseases including cancer, but contribution SPARC to malignant growth remains controversial. We previously reported was among most upregulated genes cytogenetically acute myeloid leukemia (CN-AML) patients gene-expression profiles predictive unfavorable outcome, such as mutations...
The SON protein is a ubiquitously expressed DNA- and RNA-binding primarily localized to nuclear speckles. Although several early studies implicated in DNA-binding, tumorigenesis apoptosis, functional significance of this had not been recognized until recent discovered as novel RNA splicing co-factor. During constitutive splicing, ensures efficient intron removal from the transcripts containing suboptimal splice sites. Importantly, SON-mediated required for proper processing selective related...
Background Mice deficient in the large zinc finger protein, ZAS3, show postnatal increase bone mass suggesting that ZAS3 is critical regulation of homeostasis. Although has been shown to inhibit osteoblast differentiation, its role on osteoclastogenesis not determined. In this report we demonstrated resorption by examining signaling mechanisms involved osteoclastogenesis. Methodology/Principal Findings Comparison adult wild-type and knockout (ZAS3−/−) mice showed deficiency led thicker bones...
Adults with relapsed/refractory acute lymphoblastic leukemia have a poor prognosis. While current immunotherapies are promising, they toxic, graft-versus-host disease major complication of allogeneic therapy. Here, we report patient high-risk Philadelphia chromosome-positive B-cell (ALL) following chemotherapy induction, matched related donor hematopoietic stem cell transplantation (allo-HCT), lymphocyte infusion and two tyrosine kinase inhibitors. The achieved complete molecular cytogenetic...
Military planners and commanders participate in two activities, design assessment, that are currently separate distinct processes. aims at environmental understanding crafting well-justified interventions. Assessment requires the discernment of whether these interventions working. However, logical practical connections between assessment under-theorized. We argue exercise military must become indistinguishable practice. be a continuous action as staff officers understand environment, craft...
Abstract MicroRNAs (miRs) and heterogeneous ribonucleoproteins (hnRNPs) are post-transcriptional gene regulators that bind to mRNA in a sequence-specific manner. We showed hnRNP-E2 inhibits myeloid maturation of bone marrow (BM) progenitors from chronic myelogenous leukemia patients blast crisis (CML-BC) by suppressing CEBPA translation. report here loss miR-328 is induced BCR/ABL specifically occurs CML-BC, its restored expression rescues differentiation impairs clonogenic potential...
Interstitial Cystitis or Bladder Pain Syndrome (IC/BPS) is a heterogeneous condition characterized by elevated levels of inflammatory cytokines, IL-1β, IL-6, IL-8, IL-10, TNF-α, and associated with debilitating symptoms pelvic pain frequent urination. A standard care for IC/BPS has not been established, most patients must undergo series different treatment options, potential severe adverse events. Here, we report patient 26-year history following multiple therapies, including low doses...
Abstract Despite improvement in our understanding of leukemogenic mechanisms, the majority AML patients (pts) fail to achieve long-term survival and die their disease. Therefore, new therapeutic options are needed. Silvestrol, a natural product isolated from Aglaia foveolata, has been shown have potent antitumor activity, most likely through inhibition initiation translation. Promising synergistic effects silvestrol with chemotherapy were AML, but exact mechanism mediating antileukemic...
Abstract Most AML patients (pts) fail to achieve long-term survival with current treatments. New therapeutic options are needed. We recently showed that high miR-181a expression is associated better outcome in pts normal karyotype, but the mechanisms underlying this achievement unknown. Aberrant activation of RAS due mutations or overexpression frequent human malignancies, including AML. MiR-181a has been shown target KRAS. In study, we show it also targets NRAS. With luciferase reporter...