A5066257150- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- RNA Interference and Gene Delivery
- PI3K/AKT/mTOR signaling in cancer
- Cancer therapeutics and mechanisms
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Hematopoietic Stem Cell Transplantation
- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Methemoglobinemia and Tumor Lysis Syndrome
- Cancer Treatment and Pharmacology
- Renal Transplantation Outcomes and Treatments
- Protein Degradation and Inhibitors
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- CAR-T cell therapy research
The Ohio State University
2016-2025
59th Medical Wing
2025
The Ohio State University Wexner Medical Center
2010-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2011-2024
University at Buffalo, State University of New York
2024
Comprehensive Blood & Cancer Center
2008-2024
University of North Carolina at Greensboro
2023
Ohio University
2011-2020
Medicina
2019
American Association of Colleges of Pharmacy
2012-2019
A method has been developed to measure local glucose consumption in the various structures of brain man with three-dimensional resolution. [18F]-2-deoxy-2-fluoro-D-glucose is used as a tracer for exchange between plasma and its phosphorylation by hexokinase tissue. mathematical model derived operational equation are which enable cerebral be calculated terms following measurable variables. An intravenous bolus given arterial specific activity monitored predetermined period from 30 120...
ABSTRACT Extracellular vesicles (EVs) are under evaluation as therapeutics or vehicles for drug delivery. Preclinical studies of EVs often use mice other animal models to assess efficacy and disposition. However, most derived from human cells, they may elicit immune responses which contribute toxicities enhanced EV clearance. Furthermore, different cell sources comprising various cargo differ with respect immunogenicity toxicity. To EV‐induced response toxicity, we dosed C57BL/6...
Cyclophosphamide (Cy) is a potent immunosuppressive agent that selectively toxic to lymphocytes proliferating in response recent antigen stimulation. In animal models, both graft rejection and GVHD after histoincompatible BMT can be inhibited by the posttransplantation administration of high-dose Cy. Therefore, phase I clinical trial was undertaken determine minimal conditioning, including Cy, permits stable engraftment partially HLA-mismatched marrow (up 3 HLA antigens) from first-degree...
Biliary cancers (BCs) carry a poor prognosis, but targeting the RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-related (ERK) pathway is of significance. Selumetinib an inhibitor MEK1/2, so this trial was designed to determine safety and efficacy selumetinib in BC.
Previous cell-penetrating peptides (CPPs) generally have low cytosolic delivery efficiencies, because of inefficient endosomal escape. In this study, a family small, amphipathic cyclic was found to be highly efficient CPPs, with efficiencies up 120% (compared 2.0% for Tat). These CPPs bind directly the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by release from endosome. Their total cellular uptake efficiency correlates positively binding affinity...
Abstract DNA origami (DO) nanotechnology enables the construction of precise nanostructures capable functionalization with small molecule drugs, nucleic acids, and proteins, suggesting a promising platform for biomedical applications. Despite potential drug vaccine delivery, impact DO vehicles on immunogenicity in vivo is not well understood. Here, two vehicles, flat triangle nanorod, at varying concentrations are evaluated vitro repeated dosing regimen administered high dose to study early...
Patients with chronic lymphocytic leukemia (CLL) high-risk genomic features achieve poor outcomes traditional therapies. A phase I study of a pharmacokinetically derived schedule flavopiridol suggested promising activity in CLL, irrespective features. Given the relevance these findings to treating genetically prospective confirmatory was initiated.
Abstract A collaborative study was conducted to evaluate the repeatability and reproducibility of FOSS FoodScan near-infrared spectrophotometer with artificial neural network calibration model database for determination fat, moisture, protein in meat products. Representative samples were homogenized by grinding according AOAC Official Method 983.18. Approximately 180 g ground sample placed a 140 mm round dish, dish FoodScan. The operator ID entered, product profile within software selected,...
Patients with advanced hepatocellular carcinoma (HCC) face a dismal prognosis because of lack any effective therapies. To address this situation, we conducted preclinical investigation the therapeutic efficacy oligonucleotides directed against oncogenic microRNA miR-221, which has been implicated in HCC. Of 9 chemistries evaluated, determined that 2'-O-methyl phosphorothioate-modified anti-miR-221 oligonucleotide was most at reducing proliferation vitro. A cholesterol-modified isoform...
Despite widespread use in pharmacokinetic, drug metabolism, and pesticide residue studies, little is known about the factors governing response during reversed-phase liquid chromatography coupled with negative-ion electrospray ionization (ESI-) mass spectrometry. We examined effects of various mobile-phase modifiers on ESI- four selective androgen receptor modulators using a postcolumn infusion system. Acetic, propionic, butyric acid improved responses analytes to varying extents at low...
14C-2-Deoxyglucose (2DG) was used to investigate changes in the rate of cerebral metabolism 3 rat models depressed behavior. The had already been established literature and were induced by injections alpha-methyl-para-tyrosine, withdrawal from chronic amphetamine, or stress. We verified that exploratory behaviors each model an antidepressant drug, tranylcypromine, prevented behavior model. 2DG studies revealed regional glucose elevated bilaterally lateral habenula models. Regional metabolic...
The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate was demonstrated orchidectomized rats. In current study, we characterized full S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide (a structurally related SARM referred to other publications and hereafter as S-4) skeletal muscle, bone, pituitary castrated male Twelve weeks after castration, animals were treated with S-4 (3 or 10 mg/kg),...
REOLYSIN (Oncolytics Biotech) consists of a wild-type oncolytic reovirus, which has selective cytotoxicity for tumor cells while sparing normal cells. In phase I study as single agent, repeated infusions reovirus were safe with evidence antitumor activity. Preclinical studies indicate potential synergy between and chemotherapeutic agents. A multicenter, dose escalation was designed to assess the safety combining docetaxel chemotherapy in patients advanced cancer.Patients received 75 mg/m(2)...
Background Sickle cell disease (SCD), a congenital hemolytic anemia that exacts terrible global morbidity and mortality, is driven by polymerization of mutated sickle hemoglobin (HbS) in red blood cells (RBCs). Fetal (HbF) interferes with this polymerization, but HbF epigenetically silenced from infancy onward DNA methyltransferase 1 (DNMT1). Methods findings To pharmacologically re-induce DNMT1 inhibition, first-in-human clinical trial (NCT01685515) combined 2 small molecules—decitabine to...
Research progress from mainly over the last five years is described for a multidisciplinary collaborative program project directed toward discovery of potential anticancer agents broad range taxonomically defined organisms. Selected lead compounds with as new antitumor that are representative considerable structural diversity have continued to be obtained each tropical plants, terrestrial and aquatic cyanobacteria, filamentous fungi. Recently, focus has been on investigation constituents...
Purpose Lenalidomide is effective in myeloma and low-risk myelodysplastic syndromes with deletion 5q. We report results of a phase I dose-escalation trial lenalidomide relapsed or refractory acute leukemia. Patients Methods Thirty-one adults myeloid leukemia (AML) four lymphoblastic (ALL) were enrolled. was given orally at escalating doses 25 to 75 mg daily on days 1 through 21 28-day cycles determine the dose-limiting toxicity (DLT) maximum-tolerated dose (MTD), as well provide...
The Janus kinase-2 (Jak2)-signal transducer and activator of transcription-3 (STAT3) pathway is critical for promoting an oncogenic metastatic phenotype in several types cancer including renal cell carcinoma (RCC) melanoma. This study describes two small molecule inhibitors the Jak2-STAT3 pathway, FLLL32 its more soluble analog, FLLL62. These compounds are structurally distinct curcumin analogs that bind selectively to SH2 domain STAT3 inhibit phosphorylation dimerization. We hypothesized...
Multiple myeloma (MM) is an incurable plasma-cell neoplasm for which most treatments involve a therapeutic agent combined with dexamethasone. The preclinical combination of lenalidomide the mTOR inhibitor CCI-779 has displayed synergy in vitro and represents novel MM.A phase I clinical trial was initiated patients relapsed administration oral on days 1 to 21 intravenously once per week during 28-day cycle. Pharmacokinetic data both agents were obtained, transport uptake studies conducted...
In spite of standard multimodal therapy consisting surgical resection followed by radiation and concurrent chemotherapy, prognosis for glioblastoma (GBM) patients remains poor. The identification both differentiated undifferentiated "stem cell like" populations in the tumor highlights significance finding novel targets that affect heterogeneous population. Protein arginine methyltransferase 5 (PRMT5) is one such candidate gene whose nuclear expression correlates with poor survival has been...
Myeloid derived suppressor cells (MDSC) produce nitric oxide (NO) and inhibit dendritic cell (DC) immune responses in cancer. DCs present cancer antigens to CD4+ T through Jak-STAT signal transduction. In this study, NO donors (SNAP DETA-NONOate) inhibited DC antigen presentation. As expected, MDSC isolated from peripheral blood mononuclear (PBMC) patients produced high levels. We hypothesized that producing tumor-bearing hosts would Antigen presentation (T receptor transgenic OT-II) was...