A5042947456- Genetic Mapping and Diversity in Plants and Animals
- Rice Cultivation and Yield Improvement
- Flowering Plant Growth and Cultivation
- Powdery Mildew Fungal Diseases
- Plant Gene Expression Analysis
- Plant Physiology and Cultivation Studies
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Phytochemicals and Antioxidant Activities
- Hedgehog Signaling Pathway Studies
- Tryptophan and brain disorders
- Photosynthetic Processes and Mechanisms
- Plant Pathogens and Fungal Diseases
- Attention Deficit Hyperactivity Disorder
- Plant and animal studies
- GABA and Rice Research
- Pancreatic and Hepatic Oncology Research
- Horticultural and Viticultural Research
- Plant biochemistry and biosynthesis
- Autism Spectrum Disorder Research
- Cardiovascular Conditions and Treatments
- Antioxidant Activity and Oxidative Stress
- Cancer-related Molecular Pathways
- Plant Disease Resistance and Genetics
- Bone Tumor Diagnosis and Treatments
Yale University
2018-2025
ZheJiang Academy of Agricultural Sciences
2013-2024
National Institutes of Health Clinical Center
2018-2024
Zhejiang Normal University
2023
Tobacco Research Institute
2023
University of New Haven
2018-2022
National Institutes of Health
2021-2022
Northeast Forestry University
2021
Hangzhou Academy of Agricultural Sciences
2021
Heilongjiang Provincial Academy of Agricultural Sciences
2021
Biliary cancers (BCs) carry a poor prognosis, but targeting the RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-related (ERK) pathway is of significance. Selumetinib an inhibitor MEK1/2, so this trial was designed to determine safety and efficacy selumetinib in BC.
Recent studies have demonstrated that there are significant changes in the gut microbiota (GM) of humans with depression and animal models chronic stress. In our present study, we determined whether an alteration GM is a decisive factor anxiety-like depression-like behavior its impact on brain neurochemistry. An antibiotic cocktail was used to deplete mice before they were colonized, via fecal transplantation (FMT), by control or had been exposed unpredictable mild stress (CUMS donors). The...
Abstract Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute to this enhanced CVD risk. In animal models, the Janus kinase (JAK) inhibitor tofacitinib improves clinical features, immune dysregulation and vascular dysfunction. We conducted a randomized, double-blind, placebo-controlled trial SLE subjects (ClinicalTrials.gov NCT02535689). study, 30 are randomized...
Endocrine resistance is a major challenge in the management of estrogen receptor (ER)-positive breast cancers. Although multiple mechanisms leading to endocrine have been proposed, poor outcome patients developing therapy warrants additional studies. Here we show that noncanonical Hedgehog (Hh) signaling an alternative growth promoting mechanism activated tamoxifen-resistant tumors. Importantly, phosphoinositide 3-kinase inhibitor/protein kinase B (PI3K/AKT) pathway plays key role regulating...
Sheath blight (ShB) caused by the soil-borne pathogen Rhizoctonia solani is one of most devastating diseases in rice world-wide. Global attention has focused on examining individual mapping populations for quantitative trait loci (QTLs) ShB resistance, but to date no study taken advantage association examine hundreds lines potentially novel QTLs. Our objective was identify QTLs via using 217 sub-core entries from USDA core collection, which were phenotyped with a micro-chamber screening...
In recent years, a burgeoning body of research has revealed links between depression and the gut microbiota, leading to therapeutic use probiotics for stress-related disorders. this study, we explored potential antidepressant efficacy multi-strain treatment (Lactobacillus helveticus R0052, Lactobacillus Plantarum R1012, Bifidobacterium longum R0175) in chronic mild stress (CMS) mouse model determined its probable mechanism action. Our findings that mice subjected CMS exhibited anxiety-...
As clinical applications for chimeric antigen receptor T cell (CART) therapy extend beyond early phase trials, commercial manufacture incorporating cryopreservation steps becomes a logistical necessity. The effect of on CART characteristics is unclear. We retrospectively evaluated the product release criteria and in vivo 158 autologous products from 6 single-center trials. Further, 3 healthy donor manufacturing runs, we prospectively identified differentially expressed surface markers gene...
Harvest index is a measure of success in partitioning assimilated photosynthate. An improvement harvest means an increase the economic portion plant. Our objective was to identify genetic markers associated with traits using 203 O. sativa accessions. The phenotyping for 14 conducted both temperate (Arkansas) and subtropical (Texas) climates genotyping used 154 SSRs indel marker. Heading, plant height weight, panicle length had negative correlations, while seed set grain weight/panicle...
Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare mosaic bone and endocrine disorder. Although most variants affect the GNAS R201 codon, obtaining genetic diagnosis difficult because not all cells harbor variant, an invasive biopsy may be required. We explored presence of p.R201 in blood circulating cell free DNA (ccfDNA) using sensitive techniques digital droplet polymerase chain reaction (PCR) (ddPCR) competitive allele-specific TaqMan PCR (castPCR) effort to improve FD/MAS....
Cymbidium ensifolium is a Chinese with an elegant shape, beautiful appearance, and fragrant aroma. C. has long history of cultivation in China it excellent commercial value as potted plant cut flower. The development genomic resources been delayed because its large genome size. Taking advantage technical cost improvement RNA-Seq, we extracted total mRNA from flower buds mature flowers obtained 9.52 Gb filtered nucleotides comprising 98,819,349 reads. reads were assembled into 101,423...
An association mapping of quantitative trait loci (QTLs) regulating the concentrations eight elements in brown rice (Oryza sativa L.) was performed using USDA mini-core subset cultivated two different environments. In addition, correlation between grain elemental also studied. A total 60 marker associated with 8 were identified, and these clustered into 37 genomic regions. Twenty new QTLs found to be important such as Zn, Fe, P, along others. Fe concentration greatest number markers several...
Breast cancer survivors (BCS) often complain of cancer-related cognitive impairment (CRCI) during and even months after completing primary treatments, particularly chemotherapy. The etiology CRCI is unknown, but associations with germline genetic polymorphisms have been reported, including Brain-Derived Neurotrophic Factor (BDNF) rs6265 polymorphism. current study investigated the specific BDNF CRCI.
Abstract BACKGROUND: In vitro studies in mantle cell lymphoma (MCL) lines and patient‐derived cells have demonstrated synergistic apoptosis with combined rituximab bortezomib (R‐bortezomib) compared single‐agent bortezomib. Therefore, the authors of this report evaluated R‐bortezomib a preclinical model phase 2 clinical trial. METHODS: A Hu‐MCL‐severe immunodeficiency (SCID) engrafted Jeko line was treated R‐bortezomib, bortezomib, or rituximab. Twenty‐five patients relapsed follicular (n =...
The use of sonography in musculoskeletal research and clinical applications is increasing; however, measurement techniques for diagnosing carpal tunnel syndrome with continue to be inconsistent. Novel methods using internal comparisons identify swelling the median nerve require investigation comparison currently used techniques.The flattening ratio nerve, bowing flexor retinaculum, cross-sectional area were collected forearm, at radiocarpal joint, level pisiform both symptomatic patients...
Background Flavopiridol is a cyclin-dependent kinase inhibitor in phase II clinical development for treatment of various forms cancer. When administered with pharmacokinetically (PK)-directed dosing schedule, flavopiridol exhibited striking activity patients refractory chronic lymphocytic leukemia. This study aimed to evaluate pharmacogenetic factors associated inter-individual variability pharmacokinetics and outcomes therapy. Methodology/Principal Findings Thirty-five who received...
Chinese raspberry (Rubus chingii Hu) is a fruit valued for it's health benefits, which indigenous to China. It great source of antioxidants. However, the phytochemicals are poorly understood. Phenolics and carotenoids attract much attention their antioxidant capability, they dramatically change during ripening, leading difference in color, flavor medicinal components. In this study, we investigated carotenoids, phenolics activity using spectrophotometry four different ripening phases i.e....