A5100341260- Gut microbiota and health
- Diet and metabolism studies
- Tryptophan and brain disorders
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- Phytochemistry and biological activities of Ficus species
- Plant Pathogenic Bacteria Studies
- Colorectal Cancer Screening and Detection
- Wastewater Treatment and Nitrogen Removal
- Nutritional Studies and Diet
- Probiotics and Fermented Foods
- Microbial Metabolism and Applications
- Ergonomics and Musculoskeletal Disorders
- Liver Disease Diagnosis and Treatment
- Protein Structure and Dynamics
- Muscle Physiology and Disorders
- Spondyloarthritis Studies and Treatments
- Epigenetics and DNA Methylation
- Dietary Effects on Health
- Ginseng Biological Effects and Applications
- Diet, Metabolism, and Disease
Lanzhou University
2020-2025
Lanzhou University Second Hospital
2020-2025
Baotou Medical College
2024-2025
Inner Mongolia University of Science and Technology
2024-2025
Peking University People's Hospital
2018-2025
Peking University
2018-2025
China Three Gorges University
2025
Yichang Central People's Hospital
2025
Zhejiang University
2022-2024
Xinjiang Medical University
2024
Abstract Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of complex interaction between gut microbiota and brain. Here we explore fecal microbiome based on 90 medication-free schizophrenia 81 controls identify microbial species classifier distinguishing with...
Metagenomic next-generation sequencing (mNGS) is a comprehensive approach for sequence-based identification of pathogenic microbes. However, reports on the use mNGS in pulmonary infection applied to lung biopsy tissues remain scarce. In this study, we detect presence microbes from 20 patients with disorders indicating possible infection. We new data management identifying pathogen species based data. determined thresholds unique reads and relative abundance required identify infectious...
Early treatment is key for optimizing the therapeutic success of drugs, and current initiating that blocks progression bone destruction during pre-arthritic stages remains unsatisfactory. The microbial disorder in rheumatoid arthritis (RA) patients significantly reversed with effective treatment. Modulating aberrant gut microbiomes into a healthy state potential approach preventing damage. By using metagenomic shotgun sequencing metagenome-wide association study, we assessed effect...
In recent years, a burgeoning body of research has revealed links between depression and the gut microbiota, leading to therapeutic use probiotics for stress-related disorders. this study, we explored potential antidepressant efficacy multi-strain treatment (Lactobacillus helveticus R0052, Lactobacillus Plantarum R1012, Bifidobacterium longum R0175) in chronic mild stress (CMS) mouse model determined its probable mechanism action. Our findings that mice subjected CMS exhibited anxiety-...
Asthma, one of the most common chronic respiratory disorders, is associated with hyper-activation T-cell subset adaptive immunity. The gut microbiota may be involved in development asthma through production short-chain fatty acids (SCFAs), exhibiting modulatory effects on Th. So, we performed a metagenome-wide association study (MWAS) fecal from individuals and healthy controls. And that was first case to resolve relationship between microbiome among UK adults. consisted fewer microbial...
Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to level modulation. However, the compositional alterations influences of microbiota women remain uncertain. A metagenome‐wide association study was performed compare 24 premenopausal women. Firmicutes Roseburia spp . are depleted, while Bacteroidetes toluene‐producing genus Tolumonas overrepresented fecal samples from The pentose phosphate pathway is enriched Homocysteine...
Abstract Background Laboratory rats such as the Sprague-Dawley (SD) are an important model for biomedical studies in relation to human physiological or pathogenic processes. Here we report first catalog of microbial genes fecal samples from rats. Findings The was established using 98 49 SD rats, divided 7 experimental groups, and collected at different time points 30 days apart. gene comprises 5,130,167 non-redundant with average length 750 bp, among which 64.6% 26.7% were annotated phylum...
Migraine is a very common, multifactorial, and recurrent central nervous system disorder that causes throbbing headache, photophobia, phonophobia, nausea, disability. occurs more often in females, its complex physiopathology not yet fully understood. An increasing number of gastrointestinal disorders have been linked to the occurrence migraine suggesting gut microbiota might play pivotal role through gut-brain axis. In present work, we performed metagenome-wide association study (MWAS)...
Abstract Background Osteoarthritis (OA) is a multifactorial joint degenerative disease with low-grade inflammation. The gut microbiome has recently emerged as an pathogenic factor of OA, and prebiotics supplementation could alleviate OA symptoms in animal models. However, the relationship between older female adults hitherto not clear. Results Here we studied 57 patients their healthy controls by metagenome-wide association study based on previously published data. A significant reduction...
Insulin resistance is linked to an increased risk of frailty, yet the comprehensive relationship between triglyceride glucose-body mass index (TyG-BMI), which reflects weight, and remains unclear. This investigated in this study. Data from 9135 participants China Health Retirement Longitudinal Study (2011–2020) were analysed. Baseline TyG-BMI, changes TyG-BMI cumulative baseline 2015, along with frailty (FI) over nine years, calculated. Participants grouped into different categories based on...
Among cardiovascular diseases, hypertension is the most important risk factor for morbidity and mortality worldwide, its pathogenesis complex, involving genetic, dietary environmental factors. The characteristics of gut microbiota can vary in response to increased blood pressure (BP) influence development progression hypertension. This paper describes five aspects relationship between microbiota, namely, different types metabolites sympathetic activation, gut-brain interactions, effects...
Tuberous sclerosis complex is an inherited tumour suppressor syndrome, caused by a mutation in either the TSC1 or TSC2 gene. The disease characterised broad phenotypic spectrum that can include seizures, mental retardation, renal dysfunction, and dermatological abnormalities. gene was recently identified has 23 exons, spanning 45 kb of genomic DNA, encoding 8.6 mRNA. After screening all 21 coding exons our collection 225 unrelated patients, only 29 small mutations were detected, suggesting...
Rodents respond to chronic high fat diet in at least two ways: some of them may readily gain body weight and become obese (termed obesity-prone, OP), others not obesity-resistant, OR). Transcriptomic metabonomic profiling OP OR rats has been conducted, showing sets significantly different phenotypic profiles response 16 weeks diet. We observed significant differences transcriptional expression nearly 80 genes, which are known be involved lipid metabolism, transport, ketone production. The...
Abstract STUDY QUESTION Is physical activity or sedentary time associated with semen quality parameters? SUMMARY ANSWER Among healthy men screened as potential sperm donors, higher self-reported was increased progressive and total motility. WHAT IS KNOWN ALREADY Despite the claimed beneficial effect of moderate on quality, results from epidemiological studies have been inconclusive. Previous were mostly conducted among endurance athletes male partners couples who sought infertility...
(1) Objective: To examine the association between posterior-derived dietary patterns, food variety, and frailty measured by index (FI) in Chinese elderly. (2) Method: A cohort study based on Longitudinal Healthy Longevity Survey (CLHLS) from 2014 to 2018 was conducted among older adults. The variety defined score (FVS), which calculated using frequency of categories consumption. Dietary patterns were obtained factor analysis. FI composed 38 health deficits used measure subjects’ status....
As an illicit psychostimulant, repeated methamphetamine (MA) exposure results in addiction and causes severe neurotoxicity. Studies have revealed complex interactions among gut homeostasis, metabolism, the central nervous system (CNS). To investigate disturbance of homeostasis metabolism MA-induced neurotoxicity, 2 mg/kg MA or equal volume saline was intraperitoneally (i.p.) injected into C57BL/6 mice. Behavioral tests western blotting were used to evaluate determine alterations colonic...
Gut microbiome and heredity are two important factors affecting the intramuscular fat (IMF) of cattle, excluding age, sex, nutrition. This study aimed at deciphering these differences by analyzing gut differentially expressed genes (DEGs) in Angus Chinese Simmental cattle. Feces longissimus dorsi were collected from groups animals (n = 20/group) for multiomics analysis. holds a significantly higher diversity than Simmental, relative abundance Roseburia, Prevotella, Coprococcus, etc., was...
This study aimed to investigate whether the combination of Macleaya cordata extract (MCE) and Bacillus could improve laying performance health hens better.