A5071197747- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
- Genomics and Chromatin Dynamics
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Hemoglobinopathies and Related Disorders
- Animal Genetics and Reproduction
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Sodium Intake and Health
- RNA regulation and disease
- Cancer-related gene regulation
- DNA and Nucleic Acid Chemistry
- Antioxidant Activity and Oxidative Stress
- Renin-Angiotensin System Studies
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Genetic Associations and Epidemiology
- Signaling Pathways in Disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Bengbu Medical College
2017-2024
Chinese Academy of Engineering
2017-2024
Minzu University of China
2024
Tianjin Medical University
2024
Tianjin haihe hospital
2023-2024
Northeast Forestry University
2024
State Key Laboratory of Medical Molecular Biology
2023
Fudan University
2020
Peking Union Medical College Hospital
1999-2019
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world1,2,3. A new coronavirus (SARS-CoV) was as SARS pathogen4,5,6,7, which triggered pneumonia and acute, often lethal, lung failure8. Moreover, among infected individuals influenza such Spanish flu9,10 emergence disease viruses11,12 have caused high lethality resulting from failure13. In cell lines, angiotensin-converting enzyme 2 (ACE2) has been potential...
Hazardous environmental and genetic factors can damage endothelial cells to induce atherosclerotic vascular disease. Recent studies suggest that class III deacetylase SIRT1 may promote cell survival via novel antioxidative mechanisms. The current study tested the hypothesis SIRT1, specifically overexpressed in endothelium, is atheroprotective.Human umbilical vein (HUVECs) were used effects of oxidized low-density lipoprotein (LDL) on expression. Endothelial cell-specific transgenic...
Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure considered a target the treatment of failure. However, mechanisms underlying pathological remain largely unknown. We aimed to investigate roles SIRT2 in aging-related angiotensin II (Ang II)-induced hypertrophy.Male C57BL/6J wild-type Sirt2 knockout mice were subjected investigation hypertrophy. Cardiac was also Ang (1.3 mg/kg/d 4 weeks) male mice,...
Inactivation of the p66Shc adaptor protein confers resistance to oxidative stress and protects mice from aging-associated vascular diseases. However, there is limited information about negative regulating mechanisms expression in system.In this study, we investigated role SIRT1, a class III histone deacetylase, regulation hyperglycemia-induced endothelial dysfunction.Expressions gene transcript were significantly increased by different kinds deacetylase (sirtuin) inhibitors human umbilical...
Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically increases with advancing age in men. However, the molecular mechanisms by which aging predisposes individuals to AAAs remain unknown.In this study, we investigated role SIRT1 (Sirtuin 1), class III histone deacetylase, formation and underlying linking senescence inflammation.The expression activity were significantly...
AimsOxidative stress contributes to the development of cardiac hypertrophy and heart failure. One mitochondrial sirtuins, Sirt4, is highly expressed in heart, but its function remains unknown. The aim present study was investigate role Sirt4 pathogenesis pathological molecular mechanism by which regulates oxidative stress.
Cardiac hypertrophy and failure are accompanied by a reprogramming of gene expression that involves transcription factors chromatin remodeling enzymes. Little is known about the roles histone methylation demethylation in this process. To understand role JMJD2A, trimethyl demethylase, cardiac hypertrophy, we generated mouse lines with heart-specific Jmjd2a deletion (hKO) overexpression (Jmjd2a-Tg). hKO Jmjd2a-Tg mice had no overt baseline phenotype, but did demonstrate altered responses to...
SIRT1 (Sirtuin type 1), a mammalian orthologue of yeast SIR2 (silent information regulator 2), has been shown to mediate variety calorie restriction (CR)-induced physiological events, such as cell fate regulation via deacetylation the substrate proteins. However, whether deacetylates activator protein-1 (AP-1) influence its transcriptional activity and target gene expression is still unknown. Here we demonstrate that directly interacts with basic leucine zipper domains c-Fos c-Jun, major...
Vascular smooth muscle cell (VSMC) proliferation and migration are crucial events involved in the pathophysiology of vascular diseases. Sirtuin 1 (SIRT1), a class III histone deacetylase (HDAC), has been reported to have function antiatherosclerosis, but its role neointima formation remains unknown. The present study was designed investigate SIRT1 regulation elucidate underlying mechanisms. A decrease expression observed following carotid artery ligation. (SMC)-specific human transgenic (Tg)...
Obesity and related metabolic diseases associated with chronic low-grade inflammation greatly compromise human health. Previous observations on the roles of interferon regulatory factors (IRFs) in regulation metabolism prompted investigation involvement a key family member, IRF3, disorders. IRF3 expression liver is decreased animals diet-induced genetic obesity. The global knockout (KO) significantly promotes high-fat diet (HFD)-induced hepatic insulin resistance steatosis; contrast,...
Abstract β-Thalassemia is one of the most common genetic blood diseases and caused by either point mutations or deletions in β-globin ( HBB ) gene. The generation patient-specific induced pluripotent stem cells (iPSCs) subsequent correction disease-causing may be a potential therapeutic strategy for this disease. Due to low efficiency typical homologous recombination, endonucleases, including TALENs CRISPR/Cas9, have been widely used enhance gene patient-derived iPSCs. Here, we designed...
Abstract Cellular senescence (CS), a state of permanent growth arrest, is intertwined with tumorigenesis. Due to the absence specific markers, characterizing levels and senescence-related phenotypes across cancer types remain unexplored. Here, we defined computational metrics as CS scores delineate landscape 33 29 normal tissues explored CS-associated by integrating multiplatform data from ~20 000 patients ~212 single-cell profiles. showed type-specific associations genomic immune...
Background: Timely and complete restoration of blood flow is the most effective intervention for patients with acute myocardial infarction. However, efficacy limited by ischemia-reperfusion (MI/R) injury. PDE4 (phosphodiesterase-4) hydrolyzes intracellular cyclic adenosine monophosphate it has 4 subtypes A-D. This study aimed to delineate role PDE4B (phosphodiesterase-4 subtype B) in MI/R Methods: Mice were subjected 30-minute coronary artery ligation, followed 24-hour reperfusion. Cardiac...
Nucleic acids are major structures detected by the innate immune system. Although intracellular single-stranded DNA (ssDNA) accumulates during pathogen infection or disease, it remains unclear whether and how ssDNA stimulates Here, we report that triggers cytokine expression cell death in a CGT motif–dependent manner. We identified Schlafen 11 (SLFN11) as an ssDNA-activated RNase, which is essential for responses induced adeno-associated virus infection. found SLFN11 directly binds...