A5100607171- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Antibiotic Resistance in Bacteria
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Vibrio bacteria research studies
- Advanced biosensing and bioanalysis techniques
- Single-cell and spatial transcriptomics
- Nanocluster Synthesis and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Cynara cardunculus studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Chromatin Remodeling and Cancer
- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Protein Tyrosine Phosphatases
- Metabolism, Diabetes, and Cancer
- Immune cells in cancer
- Phytochemistry and Bioactive Compounds
- Environmental Toxicology and Ecotoxicology
- Carbon and Quantum Dots Applications
- Telomeres, Telomerase, and Senescence
- RNA Research and Splicing
China Pharmaceutical University
2023-2025
Third Hospital of Hebei Medical University
2024-2025
Hebei Medical University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
State Key Laboratory of Natural Medicine
2023-2024
Second Hospital of Tianjin Medical University
2024
Tianjin Medical University
2024
Southwest University
2021-2023
Tianjin Medical University Cancer Institute and Hospital
2022-2023
Nanchang University
2023
Antimicrobial resistance leads to failure of clinical antimicrobial therapy, and has raised urgent global public health concern. Humans can acquire from drugs through the food chain or environment (contaminated water, air, soil, manure). While antimicrobials have been regular supplements in animal feed that maintain improve productivity livestock, their over-use feeding forage led a rise antibacterial resistance. This review summarizes current use harmful effects resistance, comprehensive...
Nucleic acids are major structures detected by the innate immune system. Although intracellular single-stranded DNA (ssDNA) accumulates during pathogen infection or disease, it remains unclear whether and how ssDNA stimulates Here, we report that triggers cytokine expression cell death in a CGT motif–dependent manner. We identified Schlafen 11 (SLFN11) as an ssDNA-activated RNase, which is essential for responses induced adeno-associated virus infection. found SLFN11 directly binds...
Abstract Until recently, the polymyxin antibiotics were used sparingly due to dose limiting toxicities. However, lack of therapeutic alternatives for infections caused by highly resistant Gram-negative bacteria has led increased use polymyxins. Unfortunately, world witnessed rates resistance in last decade, which is likely part its irrational human and veterinary medicine. The spread been aided dissemination transferable polymyxin-resistance gene, mcr, humans environment. mortality...
Despite the potential of small molecules and recombinant proteins to enhance efficiency homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed chemically modified, remain suboptimal for precise gene editing. Here, we screen biased ssDNA binding sequences repair-related engineer RAD51-preferred into HDR-boosting modules donors. Donors with these exhibit an augmented affinity RAD51, thereby enhancing HDR across various genomic loci cell types when cooperated...
The Chinese medicine monomer cynaroside (Cy) is a flavonoid glycoside compound that widely exists in plants and has variety of pharmacological effects, such as its important role the respiratory system, cardiovascular system central nervous system. Studies have reported Cy varying degrees anticancer activity non-small cell lung cancer, cervical liver esophageal cancer other cancers. However, there are no relevant reports about gastric cancer. MET/AKT/mTOR signaling pathway plays roles...
ABSTRACT The purpose of this study was to recognise predictive biomarkers and explore the promising therapeutic targets AD with depression. We confirmed a positive correlation between depression through MR Analysis. Through WGCNA analysis, we identified 1569 genes containing two modules, which were most related AD. In addition, 1629 depressive DEGs also identified. these genes, 84 shared by both depression, screened Degree algorithm, MCC four machine learning algorithms. Two (ITGB5 SPCS1) as...
Biological processes are controlled by groups of genes acting in concert. Investigating gene-gene interactions within different cell types can help researchers understand the regulatory mechanisms behind human complex diseases, such as tumors. We collected extensive single-cell RNA-seq data from tumors, involving 563 patients with 44 tumor types. Through our analysis, we identified various tumors and created an atlas immune subsets across Using SCINET method, reconstructed interactome...
Abstract Background Glioblastoma (GBM) is the most malignant and invasive human brain tumor. Histone demethylase 4B (KDM4B) abnormally expressed in GBM, but molecular mechanisms by which KDM4B affects tumor progression are not well defined. Methods GBM cell lines xenograft samples were subjected to quantitative PCR (qPCR), Western blot, immunohistochemical staining (IHC), as ubiquitination, immunoprecipitation (IP), chromatin (ChIP) assays investigate role of GBM. Results Here, we report...
Introduction: Lung adenocarcinoma is a common cause of mortality in patients with cancer. Recent studies have indicated that copper-related cell death may not occur the same way as previously described. Long non-coding RNAs (lncRNAs) play key role occurrence and development tumors; however, relationship between cuproptosis lncRNAs tumorigenesis lung (LUAD) treatment has been well established. Our study aimed to construct model analyze prognosis using carcinogenesis-related lncRNA (CR)...
Background: YAP, coded by YAP1 gene, is critical in the Hippo pathway. It has been reported to be involved tumorigenesis and progression of several cancers. However, its roles on tumor cell proliferation diverse cancers remain elucidated. And there currently no clinically feasible drug that can directly target YAP This research aimed explore regulatory mechanism promoting multiple cancers, order find new strategies for inhibiting overgrowth YAP-driven Methods: We investigated expression...
Today's practical partially synchronous Byzantine Fault Tolerant (BFT) consensus protocols trade off low latency and high throughput. On the one end, traditional BFT such as PBFT its derivatives optimize for latency. They require, in fault-free executions, only 3 message exchanges to commit, optimum consensus. However, this class of typically relies on a single leader, hampering throughput scalability. other new so-called DAG-BFT demonstrates how achieve highly scalable by separating data...
The serine/threonine phosphatase family is important in tumor progression and survival. Due to the high conserved catalytic domain, designing selective inhibitors challenging. Herein, we obtained compound 28a with 38-fold enhanced PP5 selectivity (PP2A/5 IC50 = 33.8/0.9 μM) improved drug-like properties (favorable stability safety, F 82.0%) by rational drug design based on a phase II PP2A/5 dual target inhibitor LB-100. Importantly, found spatial conformational restriction of indole fragment...
Platelet Membrane Cloaked Nanotubes In article number 2205260, Fazheng Ren, Yuan Li, and co-workers developed nature-inspired platelet membrane-cloaked nanotubes conjugated with targeting arginine glycine-aspartic peptide thrombolytic agent urokinase to achieve clot-targeting penetrating. This biomimetic carrier showed a promising effect in improving the efficiency vitro vivo.