A5101577230- Gut microbiota and health
- Inflammatory Bowel Disease
- Systemic Sclerosis and Related Diseases
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Single-cell and spatial transcriptomics
- Gastric Cancer Management and Outcomes
- Evolution and Genetic Dynamics
- T-cell and B-cell Immunology
- Inflammatory Myopathies and Dermatomyositis
- Neuroinflammation and Neurodegeneration Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Evolutionary Game Theory and Cooperation
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Autoimmune Bullous Skin Diseases
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Neurological Disease Mechanisms and Treatments
- Metastasis and carcinoma case studies
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Nursing Diagnosis and Documentation
- MicroRNA in disease regulation
- Health Sciences Research and Education
Capital Medical University
2015-2025
Beijing Chao-Yang Hospital
2014-2025
Shanghai University of Traditional Chinese Medicine
2022-2025
Beijing Chaoyang Emergency Medical Center
2016-2024
Beijing Anzhen Hospital
2024
China Agricultural University
2024
Beijing Hospital
2024
Baoji University of Arts and Sciences
2023
SEGi University
2022
Gansu Agricultural University
2022
Abstract Current treatment for functional dyspepsia (FD) has limited and unsustainable efficacy. Probiotics have the sustainable potential to alleviate FD. This randomized controlled clinical trial (Chinese Clinical Trial Registry, ChiCTR2000041430) assigned 200 FD patients receive placebo, positive-drug (rabeprazole), or Bifidobacterium animalis subsp . lactis BL-99 (BL-99; low, high doses) 8-week. The primary outcome was response rate (CRR) of score after 8-week treatment. secondary...
Ulcerative colitis is a chronic inflammatory bowel disorder with cellular heterogeneity. To understand the composition and spatial changes of ulcerative ecosystem, here we use imaging mass cytometry single-cell RNA sequencing to depict landscape human colon ecosystem. We find tissue topological featured macrophage disappearance reaction in region, occurring only for tissue-resident macrophages. Reactive oxygen species levels are higher but reactive scavenging enzyme SOD2 barely detected...
Patients with auto-brewery syndrome (ABS) become inebriated after the ingestion of an alcohol-free, high-carbohydrate diet. Our previous work has shown that high-alcohol-producing (HiAlc) Klebsiella pneumoniae can generate excessive endogenous ethanol and cause non-alcoholic fatty liver disease (NAFLD). Therefore, it is reasonable to speculate such bacteria might play important role in pathogenesis ABS.The characteristics metabolites intestinal flora from a clinical cohort patients ABS were...
Background Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence IBD driven complex interactions multiple factors. objective this study was to evaluate therapeutic effects IAA in colitis.
The global incidence and prevalence of inflammatory bowel disease (IBD) are gradually increasing. A high-fat diet (HFD) is known to disrupt intestinal homeostasis aggravate IBD, yet the underlying mechanisms remain largely undefined. Here, a positive correlation between dietary fat intake severity in both IBD patients murine colitis models observed. HFD induces significant decrease indole-3-acetic acid (IAA) leads barrier damage. Furthermore, IAA supplementation enhances mucin sulfation...
Objective Immune imbalance between regulatory T (Treg) and Th17 cells is a characteristic of systemic sclerosis (SSc). The functional heterogeneity among Treg can be elucidated by separating into different subsets based on the expression FoxP3 CD45RA. aim this study was to investigate role in immune naïve SSc. Methods Peripheral blood mononuclear (PBMCs) 31 SSc patients 33 healthy controls were analyzed for CD4, CD25, CD45RA, CTLA-4, FoxP3, IL-17 using flow cytometry. immunesuppression...
The integrity of the intestinal barrier is critical for homeostasis. In this study, we investigated protective effect pterostilbene (PTE) on epithelium barrier. vitro results transepithelial electrical resistance (TEER) in Caco-2 cells indicated that PTE counteracted tumor necrosis factor α (TNFα)-induced damage. vivo pretreatment markedly ameliorated dysfunction induced by dextran sulfate sodium (DSS). Notably, epithelial tight junction (TJ) molecules were restored mice exposed to DSS....
The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. S100 calcium-binding protein A6 (S100A6) has been associated with PDAC; however, the effect S100A6 on PDAC migration and invasion not yet explored. In this study, Panc-1 cells were transfected a plasmid to induce overexpression S100A6, β-catenin was knocked down using specific short hairpin RNA (shRNA). wound-healing Transwell assays demonstrated that promoted cell invasion. Furthermore, shRNA inhibited...
Isoliquiritigenin (ISL), a flavone isolated from licorice, has been demonstrated to exhibit anti-inflammatory and antioxidant properties in the treatment of Alzheimer's disease (AD). However, molecular details contribution ISL AD remain largely elusive. The present study aimed investigate mechanisms against AD. In this study, targets were collected via different databases. overlapped between generated with Venny. Then we performed Gene Ontology (GO) Kyoto Encyclopaedia Genes Genomes (KEGG)...
Polyp segmentation is crucial in computer-aided diagnosis but remains challenging due to the complexity of medical images and anatomical variations. Current state-of-the-art methods struggle with accurate polyp variability size, shape, texture. These factors make boundary detection challenging, often resulting incomplete or inaccurate segmentation. To address these challenges, we propose DCATNet, a novel deep learning architecture specifically designed for DCATNet U-shaped network that...
Background & AimsGenome-wide association studies (GWAS) and transcriptome analyses have been performed to better understand the pathogenesis of ulcerative colitis (UC). However, current mainly focus on European ancestry, highlighting a great need identify key genes, pathways cell types in colonic mucosal cells adult UC patients from other ancestries. Here we aimed genes UC.MethodsWe Single-cell RNA sequencing (scRNA-seq) analysis 12 colon biopsies healthy controls Chinese Han...
How the gut microbiota is organized across space postulated to influence microbial succession and its mutualistic relationships with host. The lack of dynamic or perturbed abundance data poses considerable challenges for characterizing spatial pattern interactions. We integrate allometric scaling theory, evolutionary game prey-predator theory into a unified framework under which quasi-dynamic networks can be inferred from static data. illustrate that such capture full properties...
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory characterized by cell infiltration and mucosal damage. The mechanism which diet contributes to the pathogenesis of IBD remains largely unknown. In this study, we explored therapeutic effect p-hydroxybenzoic acid (HA), phenolic mainly derived from dietary polyphenols in gut, on DSS-induced colitis. HA intervention effectively relieved dextran sulfate sodium salt (DSS)-induced colitis, reduced inflammation, enhanced barrier...
Abstract Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events mucus dysfunction, we discover that the Kazal-type serine protease inhibitor SPINK4 is dynamically regulated colitic intestine parallel activities. Under chemically induced conditions, grim status Spink4 -conditional knockout mice successfully rescued by recombinant murine SPINK4. Notably, its therapeutic...
The gut microbiota may play an important role in affecting human health. To explore the genetic mechanisms underlying microbiota-host relationships, many genome-wide association studies have begun to identify host genes that shape microbial composition of gut. It is becoming increasingly clear impacts processes not only through action individual microbes but also their interaction networks. However, a systematic characterization interactions occur densely packed aggregates bacteria has...
Chronic neuroinflammation has been regarded as an important part of the pathological initiation Alzheimer’s disease (AD), which is associated with regulation microglial activation. Preventing activation to inhibit may become a potential target for treatment neurodegenerative diseases. Guizhi Fuling capsule (GZFL) strong repression on inflammatory responses. Here, presenilin1/2 conditional double knockout (PS cDKO) mice, well-established mouse model AD, were divided into: WT mice (WT),...
AIMTo investigate the role of regulatory T cell (Treg) subsets in balance between Treg and helper 17 (Th17) cells various tissues from mice with dextran sulfate sodium-induced colitis. METHODSTreg cells, subsets, Th17 CD4 + CD25 FoxP3
Purpose This empirical survey is conducted to investigate the prevalence rate of academic dishonesty (AD) in examinations and assignments among undergraduates. The study compared difference admitted behaviours between male female students comprising second-year, third-year fourth-year from discipline business, engineering, information technology (IT) education. Design/methodology/approach A cross-sectional was utilized this collected data via online questionnaire. total 1,624 respondents...