A5100361139- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Forensic and Genetic Research
- interferon and immune responses
- Cleft Lip and Palate Research
- Inflammatory Biomarkers in Disease Prognosis
- Galectins and Cancer Biology
- Clostridium difficile and Clostridium perfringens research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Congenital gastrointestinal and neural anomalies
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Infant Nutrition and Health
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Pediatric Hepatobiliary Diseases and Treatments
Chongqing Medical University
2024-2025
Second Affiliated Hospital of Chongqing Medical University
2024-2025
South China Agricultural University
2014-2025
Dalian Medical University
2024-2025
Sun Yat-sen University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Beijing Chaoyang Emergency Medical Center
2024
Capital Medical University
2024
Wuxi No.2 People's Hospital
2023
Altered gut microbiota are assumed to be involved in the pathogenesis of irritable bowel syndrome (IBS). However, alterations reported different studies divergent and sometimes even contradictory. To better elucidate relationship between altered IBS, we characterized fecal diarrhea-predominant IBS (IBS-D) patients further explored effect rifaximin on using bacterial 16S rRNA gene-targeted pyrosequencing. In our study, IBS-D defined by Rome III criteria age-and-gender matched healthy controls...
Avian orthoreovirus (ARV) is a significant pathogen causing viral arthritis, leading to substantial economic losses in the poultry industry worldwide. A novel ARV strain, designated FJ202311, was isolated from broiler farm Fujian Province, China. Whole-genome sequencing conducted using next-generation with MGI technology, and phylogenetic analysis of sigma C amino acid sequence performed. Comparative identified unique genetic features FJ202311. Pathogenicity studies were carried out by...
The euglycemic clamp test stands as the best method for assessing pharmacokinetic and pharmacodynamic properties of long-acting insulin. However, despite its widespread use, there remains a notable absence an established gold standard evaluating test's quality. Existing recommendations from regulatory agencies lack specific threshold values, particularly concerning This study aimed to determine evaluation criteria quality insulin glucose improve overall this testing method. Fifty-three...
Summary Background Owing to the importance of early treatment, simple and reliable methods for monitoring inflammatory bowel disease (IBD) are needed. Aims To determine whether circulating microRNAs biomarkers IBD monitoring. Methods Serum levels 17 candidate were measured by quantitative real‐time polymerase chain reaction in a discovery cohort (n = 120). Differentially expressed serum further investigated an independent training 341). Correlations between relative microRNA activity...
Intestinal homeostasis disorder is critical for developing Crohn's disease [CD]. Maintaining mucosal barrier integrity essential intestinal homeostasis, preventing injury and complications. Among the remarkably altered long non-coding RNAs [lncRNAs] in CD, we aimed to investigate whether metastasis-associated lung adenocarcinoma transcript 1 [MALAT1] modulated CD consequent disruption of homeostasis.Microarray analyses on mucosa patients controls were performed identify dysregulated lncRNAs....
Regulatory IL-10-producing B cells (B10 cells) play a critical role in preventing and curing autoimmune diseases experimental mouse models. However, the precise cellular molecular mechanisms of action B10 humans, especially patients with Crohn's disease (CD), remain to be determined. miR-155 regulates many physiological pathological conditions, including inflammation such as that CD. In this study, we aimed explore effect miRNA-155 on IL-10 production by healthy controls (HCs) CD patients....
Abstract Background Fecal lactoferrin (FL) is associated with disease activity and relapse in ulcerative colitis. However, whether FL could early predict long‐term outcomes colitis poorly understood. Methods This post‐hoc analysis included participants who received biologics had available data of concentration at week 4 from the UNIFI PURSUIT trials ( n = 1063). Therapeutic outcomes, including clinical remission, endoscopic improvement histological were evaluated end maintenance therapy. The...
Abstract Background Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn’s disease. We identify cadherin superfamily member protocadherin 20 (PCDH20) as crucial factor Here we describe function PCDH20 and its mechanisms gut homeostasis, integrity, disease development. Results mRNA protein expression is significantly downregulated colonic epithelium patients mice with induced colitis compared controls. In mice, intestinal-specific Pcdh20 knockout causes...
Interleukin (IL)-9 drives gut inflammation, but its role in Crohn's disease (CD) is unclear. We aimed to analyze correlations between serum IL-9 levels and severity evaluate their predictive value relation the clinical efficacy of infliximab (IFX) patients with CD.Between January 2013 December 2015, 100 consecutive active CD 50 age- sex-matched control individuals were recruited from a tertiary center. Their measured using an enzyme-linked immunosorbent assay. Correlations examined. The...
Abstract Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events mucus dysfunction, we discover that the Kazal-type serine protease inhibitor SPINK4 is dynamically regulated colitic intestine parallel activities. Under chemically induced conditions, grim status Spink4 -conditional knockout mice successfully rescued by recombinant murine SPINK4. Notably, its therapeutic...
OBJECTIVES: Mucosal healing (MH) is the goal of “treat to target” strategy in Crohn's disease (CD), which seeks prevent disability. However, evidence limited regarding whether achieving MH can reduce disability CD. We aimed estimate probability disabling and investigate association between METHODS: This was a retrospective case-control study 319 consecutive CD patients. The primary outcome occurrence (defined as surgery, hospitalizations, steroid dependency, or complications). secondary...