A5072488231- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Diagnosis and treatment of tuberculosis
- Cardiac electrophysiology and arrhythmias
- Chronic Lymphocytic Leukemia Research
- Cardiovascular Syncope and Autonomic Disorders
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Acute Lymphoblastic Leukemia research
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Mycobacterium research and diagnosis
- Extracellular vesicles in disease
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
Second Military Medical University
2004-2024
Changhai Hospital
2024
Powerchina Huadong Engineering Corporation (China)
2024
PowerChina (China)
2024
Creative Commons
2020-2023
Hebei University of Science and Technology
2022
University of Benin
2018-2021
Shanghai Sixth People's Hospital
2018-2021
Importance Olamkicept, a soluble gp130-Fc-fusion-protein, selectively inhibits interleukin 6 (IL-6) trans-signaling by binding the IL-6 receptor/IL-6 complex. It has anti-inflammatory activities in inflammatory murine models without immune suppression. Objective To assess effect of olamkicept as induction therapy patients with active ulcerative colitis. Design, Setting, and Participants Randomized, double-blind, placebo-controlled phase 2 trial 91 adults colitis (full Mayo score ≥5, rectal...
The IL23/Th17 pathway is essential for the onset of inflammatory bowel disease (IBD), yet specific mechanism by which this initiates remains unknown. In study, we identify mechanisms that mediate cross-talk between IL23 and intestinal barrier in IBD. downstream targets were identified RNA array profiling confirmed immunohistochemical staining. role miRNAs interact with was explored mice TNBS-induced colitis. Claudin-8 (CLDN8), a multigene family protein constitutes backbone tight junctions,...
Abstract MicroRNAs are critical post-transcriptional regulators of gene expression and key mediators pathophysiology inflammatory bowel disease (IBD). This study is aimed to the role miR-665 in progression IBD. Real-time PCR analysis was used determine 89 freshly isolated IBD samples dextran sulfate sodium (DSS)-induced colonic mucosal tissues. The inducing apoptosis colitis were examined by Annexin V, TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling) staining, colony...
Abstract Therapeutic applications of tissue-derived mesenchymal stem cells (MSCs) are hindered by their limited expansion ability and variation across donors. Human induced pluripotent cell (iPSC)-derived MSCs show greater expandability therefore offer potential for use in tissue repair therapies. Here we explored the regenerative effects iPSC-MSCs mechanisms which promote mucosal healing via tumor necrosis factor-α-stimulated gene 6 (TSG-6) mouse models inflammatory bowel disease (IBD)....
Magnitude and diversity of gut microbiota metabolic systems are critical in shaping human health diseases, but it remains largely unclear how complex metabolites may selectively regulate determine diseases. Here, we show that failures or compromised effects anti-TNF-α therapy inflammatory bowel diseases (IBD) patients were correlated with intestinal dysbacteriosis more pro-inflammatory bacteria, extensive unresolved inflammation, failed mucosal repairment, aberrant lipid metabolism,...
Endoscopy is an important tool in screening and monitoring inflammatory bowel disease (IBD); however, it invasive, costly, associated with risks to the patients. Recently, circulating microRNAs (miRNAs) have emerged as promising noninvasive biomarkers. We proposed that expression of serum microRNA223 (miR-223) could be a biomarker for IBD.Studies were conducted using samples from 100 patients IBD (50 Crohn's [CD] 50 ulcerative colitis [UC]) healthy controls. The miR-223 was measured by...