A5057757181- Gut microbiota and health
- Circular RNAs in diseases
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Salivary Gland Disorders and Functions
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Microbial Community Ecology and Physiology
- Mycorrhizal Fungi and Plant Interactions
- Respiratory viral infections research
- Plant Pathogens and Fungal Diseases
- Oral microbiology and periodontitis research
- Venomous Animal Envenomation and Studies
- Immune Response and Inflammation
- Healthcare and Venom Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Soil Carbon and Nitrogen Dynamics
- Genomics and Phylogenetic Studies
- Angiogenesis and VEGF in Cancer
- Barrier Structure and Function Studies
- Fungal Biology and Applications
- Nutrition, Genetics, and Disease
- Lichen and fungal ecology
- Vitamin D Research Studies
- Nutrition and Health in Aging
Nanjing University of Chinese Medicine
2018-2024
Qinghai University
2022-2024
Capital Medical University
2019-2024
Guizhou Minzu University
2024
China-Japan Friendship Hospital
2015-2023
Shanxi University
2022-2023
University of Leeds
2023
Peking University
2015-2022
Guiyang Medical University
2019-2022
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2019-2022
It is very difficult to prevent pulmonary tuberculosis (TB) due the lack of specific and diagnostic markers, which could lead a high incidence TB. We screened differentially expressed serum microRNAs (miRNAs) as potential biomarkers for diagnosis TB.In this study, miRNAs were using Solexa sequencing method The stem-loop quantitative reverse-transcription polymerase chain reaction (qRT-PCR) assay was used verify miRNAs. receiver operating characteristic (ROC) curve logistic regression model...
Ulcerative colitis (UC) is a chronic, relapsing, and nonspecific inflammatory bowel disease (IBD). Phillygenin (PHI), natural bioactive ingredient, isolated from Forsythiae Fructus, exhibits anti-inflammatory, anti-oxidative, hepatoprotective activities. However, few reports provide direct evidence on the efficacy of PHI in improving mice. The present study elucidated that symptoms DSS-induced mice were alleviated after administration, including body weight loss, activity index, colon length...
Background Asthma is a complex pulmonary inflammatory disease, which characterized by airway hyperresponsiveness, variable airflow obstruction and inflammation in the airways. The majority of asthma allergic asthma, disease caused type I hypersensitivity mediated IgE. Exposures to number environmental chemicals are suspected lead one such pollutant di-(2-ethylheyl) phthalate (DEHP). DEHP manufactured chemical that commonly added plastic products make them flexible. Epidemiological studies...
The development of food allergy has been reported to be related with the changes in gut microbiome, however specific microbe associated pathogenesis remains elusive. This study aimed comprehensively characterize microbiome and identify individual or group microbes relating food-allergy using 16S rRNA gene sequencing network analysis. Faecal samples were collected from children IgE-mediated allergies (n = 33) without 27). Gut was profiled by sequencing. OTUs obtained then used construct a...
Abstract Hyperuricemia closely correlates with the development of atherosclerosis, but little is known mechanism by which atherosclerosis progression occurs in hyperuricemia. Atherosclerosis appears to involve pyroptosis, an emerging proinflammatory regulated cell death. This study tested hypothesis that pyroptosis underlies relationship between hyperuricemia and using ApoE −/− mice (a model atherosclerosis), human umbilical vein endothelial cells (HUVECs), atherosclerotic arterial samples....
Background The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks not been fully understood. It is confirmed that exposure environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung function impairment exacerbation pre-existing diseases. However, the adverse effect nanoparticles on allergic asthma seldom investigated mechanism remains undefined. For first time, this work investigates...
Endoscopy is an important tool in screening and monitoring inflammatory bowel disease (IBD); however, it invasive, costly, associated with risks to the patients. Recently, circulating microRNAs (miRNAs) have emerged as promising noninvasive biomarkers. We proposed that expression of serum microRNA223 (miR-223) could be a biomarker for IBD.Studies were conducted using samples from 100 patients IBD (50 Crohn's [CD] 50 ulcerative colitis [UC]) healthy controls. The miR-223 was measured by...
This study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and potential gene targets atherosclerosis.A total 60 CAD 25 healthy control subjects were recruited this study. Among patients, 18 cases diagnosed stable angina pectoris (SAP), 20 unstable (UAP) 22 acute myocardial infarction (AMI). Plasma levels from both groups participants analyzed by real-time quantitative PCR. ELISA was used measure plasma level placenta growth factor (PLGF).The results showed...
Background: Tanshinone IIA (Tan IIA), a lipophilic constituent from Salvia miltiorrhiza Bunge, has shown promising cardioprotective effect including anti-atherosclerosis. This study aims at exploring Tan IIA's anti-inflammatory and immune-regulating roles in stabilizing vulnerable atherosclerotic plaque ApoE-deficient (ApoE-/-) mice. Methods: Male ApoE-/- mice (6 weeks) were fed with high-fat diet for 13 weeks then randomized to the model group (MOD) or groups [high dose: 90 mg/kg/day (HT),...
Circulating microRNAs (miRNAs) are emerging as novel biomarkers for detecting cardiovascular diseases. In this study, we aimed to investigate the usefulness of miRNAs in diagnosing and predicting children with congenital heart defects (CHD), particularly context multiple subtypes CHD. We recruited 26 families, each having a child CHD parents who do not have any disorder. 27 families unaffected by disease were also included controls. Firstly, screened 84 circulating relating development 6...
Continuous cropping often leads to an unbalanced soil microbial community, which in turn negatively affects functions. However, systematic research of how these effects impact the bacterial composition, functional traits, and metabolites is lacking. In present study, rhizosphere samples Tibetan barley continuously monocropped for 2 (CCY02), 5 (CCY05), 10 (CCY10) years were collected. By utilizing 16S high-throughput sequencing, untargeted metabolomes, quantitative element cycling smart...
BackgroundThe prevalence of allergy and other common chronic diseases is higher in developed than developing countries, urban rural regions. Urbanization through its modification environmental microbiomes may play a predominant role the development these conditions. However, no studies have been conducted to compare microbiome house dust among areas with different urbanization levels.MethodsHouse from Xinxiang area (XR, n = 74), (XU, 33), Zhengzhou (ZU, 32) central China, Australia (AU, 58...
The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R TNF-α), lung function five respiratory/allergic...
Nearly all the investigations into risk factors for wheezing and asthma were conducted in developed countries with a high prevalence rate of allergy, but studies developing are limited. In this study, we aimed to investigate different phenotypes Chinese young children explore prognosis recurrent wheezing. This cohort study contained recruitment stage follow-up by phone questionnaire survey. According information collected at episodes remission age, our was divided transient wheezing,...
Kobresia humilis is a major species in the alpine meadow communities of Qinghai-Tibet Plateau (QTP); it plays crucial role maintaining ecological balance these meadows. Nevertheless, little known about rhizosphere fungi associated with K. on Qinghai Tibet Plateau. In this study, we used Illumina Miseq to investigate fungal diversity, community structure, and types root soil across eight areas QTP analyzed correlation between environmental factors. A total 19,423 25,101 operational taxonomic...
Ulcerative colitis (UC) is an idiopathic, relapsing, and etiologically complicated chronic inflammatory bowel disease. Despite substantial progress in the management of UC, outcomes mucosal barrier repair are unsatisfactory. In this study, phillygenin (PHI) treatment alleviated symptoms mice, including body weight loss, severe disease activity index scores, colon shortening, splenomegaly, oxidative stress, response. particular, PHI ameliorated tight junction proteins (TJs) reduction,...
This study investigated the impact of vitamin D status on susceptibility and severity viral pneumonia (VP) in children. A total 236 children with VP, aged from 1 month to 14 years, 271 gender age matched healthy compare serum 25(OH)D levels status. Vitamin indices were compared between subgroups VP cases. The median [interquartile range (IQR)] level these 507 was 23.7 (IQR 17.5–30.6) ng/mL; 134 (26.4%) sufficient [25(OH)D ≥30 ng/mL], whereas 373 (73.6%) insufficient, which included...
Smoke has been proved to be one of the most dangerous ingredients leading unsatisfying treatment response asthmatics inhaled corticosteroids (ICS) therapy. Macrolides, a class antibiotics, possess traits immunomodulation and anti-inflammation besides antimicrobial activity. Given that studies on efficacy macrolides refractory asthma patient have diverting conclusions, this article was carried investigate effects macrolide airway inflammation smoke-exposed asthmatic mice.
Abstract Background The complement system plays a critical role as the pathogenic factor in models of acute lung injury due to various causes. Cobra venom (CVF) is commonly used research tool. CVF can cause inflammation by producing activation components. Atorvastatin (ATR) 3-hydroxy-3-methylglutaryl coenzyme A inhibitor approved for control plasma cholesterol levels. This reduce pulmonary inflammatory response. However, ability ATR treating caused still unknown. Therefore, we investigated...
Abstract Background Trends in food allergies prompted investigation into the underlying mechanisms. Genetic and epigenetic factors are of high interest, and, particular, interplay between genes relating to immune directly indirectly involved allergy pathogenesis. We sought determine potential links gene expression Toll‐like receptor (TLR) pathways childhood allergies. Methods In a cross‐sectional study, samples from 80 children with without were analysed for expression, DNA methylation range...
Abstract Background Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter human with new microbiome profile established Chinese immigrants, which fails prime system. Here, we investigated how differences composition of oropharyngeal may contribute patterns interaction between system immigrants living Australia. Methods We recruited 44 adult immigrants: newly-arrived (n = 22, Australia < 6 months) long-term...