A5024529060- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Gut microbiota and health
- Clinical Nutrition and Gastroenterology
- Pancreatitis Pathology and Treatment
- Venous Thromboembolism Diagnosis and Management
- Asthma and respiratory diseases
- Antibiotic Use and Resistance
- Inflammatory Biomarkers in Disease Prognosis
- Antibiotic Resistance in Bacteria
- Immune Cell Function and Interaction
- Gastroesophageal reflux and treatments
- Alcohol Consumption and Health Effects
- Endoplasmic Reticulum Stress and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Liver Diseases and Immunity
- Cancer-related Molecular Pathways
- Renal and related cancers
National Clinical Research Center for Digestive Diseases
2024
Capital Medical University
2023-2024
Beijing Friendship Hospital
2023-2024
Chinese PLA General Hospital
2024
Peking University
2019-2022
Zhengzhou University
2016-2019
Peking University Shenzhen Hospital
2018
University of Hong Kong - Shenzhen Hospital
2018
Gansu Provincial Maternal and Child Health Hospital
2016
Objective: To explore and analyze the possible mechanism of liver injury in patients with coronavirus disease 2019 (novel pneumonia, NCP). Methods: The correlation between ALT, AST other enzyme changes condition NCP patients' status reported literature was comprehensively analyzed. ACE2 expression tissue for novel analyzed based on single cell sequencing (GSE115469) data. RNA-Seq method used to Ace2 transcription factors related its tissues at various time-points after hepatectomy mouse...
Abstract Hepatitis B virus (HBV) integration exists throughout the clinical course of chronic hepatitis (CHB). This study investigated effects long‐term antiviral therapy on level and profiles transcriptionally active HBV integration. Serial liver biopsies paired blood samples were obtained from 16, 22 patients with CHB at baseline, 78, 260 weeks entecavir monotherapy or combined pegylated interferon alfa, respectively. Serum biomarkers longitudinally assessed. RNA‐seq HIVID2 program was...
Background and Aims: The poor outcomes of hepatocellular carcinoma (HCC) patients may be due to not only malignant tumors but also limited liver function. Therefore, as stated in major guidelines, with relatively normal function (Child-Pugh A) would referred for curative hepatectomy. Even so, the postsurgery survival rate is still extremely poor. Direct resection benefit most patients. This study aimed improve prognosis predicting accuracy Child-Pugh scoring system.
Aims: To date, curative resection remains to be the most optimal therapeutic choice of hepatocellular carcinoma (HCC), though overall survival (OS) extremely unsatisfactory. better manage HCC patients, we evaluated prognosis predicting values apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) on long-time patients who underwent surgical treatment in this study. Methods: A subgroup 164 from our previously described follow-up cohort were enrolled study, whom pre-surgery...
Aims . Persistent hepatic necroinflammatory damage almost always results in fibrosis/cirrhosis or even hepatocellular carcinoma. Therefore, the presence of active necroinflammation liver suggests that nonalcoholic fatty disease (NAFLD) patients are urgent need treatment. Unfortunately, alanine transaminase (ALT), a routine indicator inflammatory damage, showed poor performance steatohepatitis (NASH) patients. Thus, it will be valuable to find an alternative identify with damage. In this...
Golgi protein 73 (GP73) is upregulated in a variety of liver diseases, yet the detailed mechanism poorly characterized. We analyzed GP73 retrospective cohort including 4211 patients with chronic disease (CLD) or hepatocellular carcinoma (HCC). The effect deoxycholic acid (DCA) and nuclear factor-kappa B (NF-κB) on expression release Huh-7 SMMC7721 cells were studied. A mouse study was used to confirm our findings vivo. positive correlation found between serum total bile (TBA) cirrhotic (r =...
Background and Aim . Serum Golgi protein 73 (GP73) is a promising alternative biomarker of chronic liver diseases, but most data are from patients with HBV infection rather than HCV. Materials Methods Two independent cohorts hepatitis C (CHC) the 5th Medical Centre Chinese PLA General Hospital (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>174</mml:mn></mml:math>) Beijing Youan...
Background and Aims: Non-invasive evaluation of liver necroinflammation in patients with chronic disease is an unmet need clinical practice. The diagnostic accuracy transient elastography-based stiffness measurement (LSM) for fibrosis could be affected by necroinflammation, the latter which intensify liver. Such results have prompted us to explore diagnosis potential LSM inflammation. Methods: Three cross-sectional cohorts biopsy-proven were enrolled, including 1417 hepatitis B (CHB) from 10...
Several previous studies have investigated the association between gene p53 (p53) mutation and poor outcome of primary liver cancer (PLC) patients; however, results remain inconsistent. In present study, in 60 paired tumor corresponding nontumor tissues derived from a cohort PLC patients was systematically analyzed. The showed that only an independent risk factor for overall survival (OS), not recurrence-free (RFS), meta-analysis performed to verify this. Online databases were searched up...
This study was designed to explore if antiviral treatment influences the performance of serum alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) among high-risk chronic HBV-infected patients. A total 5936 patients who had evidence HBV infection were enrolled from four independent centres in this retrospective study, including 1721 hepatitis B (CHB), 2286 liver cirrhosis (LC), 798 HCC within Milan criteria and 1131 beyond Stratified by whether they received or not, further divided...
To investigate the changes in red blood cell count patients with different liver diseases and correlation between degree of damage.The clinical data 1427 primary cancer, 172 cirrhosis, 185 hepatitis were collected, Child-Pugh class was determined for all patients. The differences retrospectively analyzed, function status investigated. Mann-Whitney U test, Kruskal-Wallis H rank sum Spearman chi-square test performed types data.Red showed significant chronic hepatitis, cirrhosis highest lowest...
As a hepatocellular carcinoma biomarker, serum Golgi protein 73 (GP73) is reportedly related to inflammation. Acute-on-chronic liver failure (ACLF) characterized by severe systemic In this study, we aimed explore the association between GP73 level and short-term mortality in patients with alcohol-associated disease-related ACLF (ALD-ACLF).This retrospective cohort study involved 126 Chinese adults ALD-ACLF. Baseline was measured using enzyme-linked immunosorbent assay. Patients were...
Objective: To establish and evaluate diagnostic efficacy applicability of serum Golgi protein (GP) 73 based non-invasive model with other conventional serological indicators for compensated stage hepatitis B cirrhosis. Methods: 666 cases chronic (CHB) who had visited to the Fifth Medical Center People's Liberation Army General Hospital from January 2010 December 2017 were selected as study subjects, classified according cirrhosis into clinical pathological diagnosis group on whether or not...
Chronic hepatitis B virus (HBV) infection is a major global public health problem. Approximately 887,000 people die of HBV infection-related diseases annually, with cirrhosis and hepatocellular carcinoma (HCC) being the principal causes mortality.[1] Timely antiviral therapy greatly reduces risks HCC. However, unfortunately, those patients who are eligible for treatment, only 25% in clinic settings 12% community obtain timely therapy.[2] Therefore, reliable means identifying chronic that...
There is still a large number of patients with chronic hepatitis B virus (HBV) infection in China, which greatly affects the health Chinese people. With change lifestyle, incidence rate nonalcoholic fatty liver disease (NAFLD) increasing year by China. Some clinical studies have shown that there relatively low HBV NAFLD, while are reports on NAFLD promoting progression B-related diseases. Based literature search and review, this article attempts to investigate interaction between...