A5023070022- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 detection and testing
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Metabolism and Genetic Disorders
- Reproductive tract infections research
- Vaccine Coverage and Hesitancy
- Retinal and Macular Surgery
- Vector-Borne Animal Diseases
- Hematopoietic Stem Cell Transplantation
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Chronic Myeloid Leukemia Treatments
- COVID-19 Impact on Reproduction
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Mass Spectrometry Techniques and Applications
- Nutrition and Health in Aging
- Hormonal and reproductive studies
- Intraocular Surgery and Lenses
National Center for Clinical Laboratories
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Beijing Hospital
2016-2025
Wuxi Taihu Hospital
2022-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Sorrento Therapeutics (United States)
2020-2023
Giessen School of Theology
2023
Justus-Liebig-Universität Gießen
2023
University of Nebraska Medical Center
2023
North Carolina State University
2023
Abstract Acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (HCT) is a primary cause of nonrelapse mortality and major barrier to successful transplant outcomes. Itacitinib Janus kinase (JAK)1–selective inhibitor that has demonstrated efficacy in preclinical models aGVHD. We report results from the first registered study JAK patients with This was an open-label phase 1 enrolling aged ≥18 years HCT any source who developed grade IIB IVD Patients...
In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in cities Wuhan, Shenzhen, and Shijiazhuang China. From January to April 2020, 38,144 healthy three were tested for total antibody against followed by pseudotype neutralization tests, IgG, IgM testing. Finally, a 398 confirmed positive. The age- sex-standardized 18-60 year-old adults (18-65 Shenzhen) was 2.66% (95% CI: 2.24%-3.07%) 0.033% 0.0029%-0.267%) 0.0028% 0.0001%-0.158%) Shijiazhuang,...
This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH 53 individuals aged 18-59 years who had received an vaccine in two Chinese cities April June 2021. Blood samples were tested for vaccines. The prevalence severity adverse events associated similar seropositivity neutralizing activity against authentic SARS-CoV-2, total amount antibody (total antibody) S-IgG 71.3%, 81.9%, 92.6%,...
The molecular mechanism controlling the dismantling of naive pluripotency is poorly understood. Here we show that microRNAs (miRNAs) have important roles during to primed transition. Dgcr8−/− embryonic stem cells (ESCs) failed completely silence program, as well establish program differentiation. miRNA profiling revealed expression levels a large number miRNAs changed dynamically and rapidly Furthermore, screen identified numerous promoting Unexpectedly, multiple from miR-290 miR-302...
// Jiangbo Zhang 1, 2, * , Jin Cheng 3, Zhenzhen Zeng Yongfeng Wang 1 Xiaojun Li Qing Xie 4 Junqiao Jia Ying Yan Zhengyang Guo Jian Gao Mingjie Yao Xiangmei Chen Fengmin Lu Department of Microbiology & Infectious Disease Center, School Basic Medical Sciences, Peking University Health Science Beijing 100191, China 2 Sun Yat-sen Cancer State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou 510060, 3 Institute Sports Injuries, Third Hospital,...
Hepatocyte proliferation could result in the loss of covalently closed circular DNA (cccDNA) and emergence cccDNA-cleared nascent hepatocytes, which appear refractory to hepatitis B virus (HBV) reinfection with unknown mechanism(s). Sodium taurocholate cotransporting polypeptide (NTCP) is functional receptor for HBV entry. In this study, down-regulation cell membrane localized NTCP expression proliferating hepatocytes was found prevent infection HepG2-NTCP-tet cells liver-humanized mice....
Little is known about the diversity of residents' preferences for COVID-19 vaccines during time when management was downgraded in China. This study aims to investigate these using discrete choice experiment (DCE) and profile case best–worst scaling (BWS-2), assess concordance between two methods. Chinese residents recruited online survey were asked evaluate vaccine profiles through both DCE BWS-2 from April July 2023. Attributes included effectiveness, duration protection, risk severe...
The significance of occult hepatitis B virus (HBV) infection (OBI) has been increasingly recognized while the underlying mechanisms remain incompletely understood. This study aimed to identify high-frequency OBI-related mutations in HBV surface antigen (HBsAg)-negative samples tested by ultrasensitive Lumipulse G HBsAg-Quant assay. OBI were collected from 32 blood establishments across 14 provinces China. assay was performed for re-testing and reclassification OBI. Mutations genotypes (GTB)...
<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) has been recognized as a pandemic by the World Health Organization. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also infect tissues besides system, such ocular tissues, remains unclear. <h3>Objective</h3> To determine whether SARS-CoV-2 exists intracellularly in of patient previously infected with COVID-19. <h3>Design, Setting, and Participants</h3> This case study analyzed COVID-19 who had an glaucoma...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA could be detected in the blood of infected cases. From February 9, all establishments Hubei province, China, implemented nucleic acid testing (NAT) for SARS-CoV-2 among donors to ensure safety.Nucleic test screening individually (ID) or by minipool (MP) was performed according manufacturer's instructions. Inactivated culture supernatant SARS-CoV-2-infected Vero cells quantified droplet digital polymerase chain reaction (ddPCR)...
Abstract Background The HTLV-1 prevalence in China varies geographically, while HTLV-2 infection has rarely been found so far. Proviral load is one of the determining factors pathogenesis and progression related diseases. However, neither molecular assays nor commercial kits are available for diagnosis China. objective present study was to develop validate a TaqMan qPCR assay proviral quantification. Results A plasmid containing both interest fragment RNase P (RPPH1) gene constructed used...
C-21 steroids displayed the activities of immunosuppressive, anti-inflammatory and anti-virus effects by reports. However, its antitumor molecular mechanism remain unclear. We previously isolated identified a steroidal glycoside (BW18) from root Cynanchum atratum Bunge. This study was aimed to assess anti-leukemia activity underlying in K562 cells. MTT assay results showed that BW18 inhibited cell viability proliferation also found could induce S phase cycle arrest apoptosis. Furthermore,...
To compare clinical outcomes in eyes with macular hole (MH) managed by either facedown (FD) or no-FD (nFD) postoperative positioning protocols.This is a prospective randomized cohort study. Eighty of 80 consecutive patients MH who had undergone vitrectomy surgery internal limiting membrane peeling and gas tamponade were included this Forty 40 kept FD position for 3 days after assigned to the group, nFD group. Macular was examined swept-source optical coherence tomography images at 1 day, 2...