A5101483598- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Bladder and Urothelial Cancer Treatments
- Cardiac Imaging and Diagnostics
- Neuroblastoma Research and Treatments
- Quantum and electron transport phenomena
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Bauxite Residue and Utilization
- Quantum Information and Cryptography
- Aluminum Alloy Microstructure Properties
- SARS-CoV-2 and COVID-19 Research
- Cardiac pacing and defibrillation studies
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Cancer therapeutics and mechanisms
- Quantum Computing Algorithms and Architecture
- Prostate Cancer Diagnosis and Treatment
- Aluminum Alloys Composites Properties
- Acute Kidney Injury Research
- Central Venous Catheters and Hemodialysis
- Advanced MRI Techniques and Applications
- Cardiac Arrhythmias and Treatments
Third Xiangya Hospital
2015-2025
Central South University
2015-2025
Lanzhou University
2021-2025
First Hospital of Lanzhou University
2021-2025
Capital Medical University
2010-2024
Shandong First Medical University
2023-2024
Shandong Provincial Institute of Dermatology and Venereology
2013-2024
Hefei National Center for Physical Sciences at Nanoscale
2023-2024
University of Science and Technology of China
2005-2024
State Key Laboratory of Vehicle NVH and Safety Technology
2024
Abnormalities in left ventricular (LV) structure and function occur patients with diastolic heart failure (DHF). The reasons for the transition from asymptomatic dysfunction to need better definition, including noninvasive measurements that can detect transition.In 64 undergoing right catheterization, simultaneous echocardiographic imaging was performed. As a control group, 27 healthy subjects were included. There 25 ejection factor (EF) <50%, 20 DHF, 19 normal EF LV hypertrophy but not...
Abstract Our preliminary work has revealed that vitamin D receptor (VDR) activation is protective against cisplatin induced acute kidney injury (AKI). Ferroptosis was recently reported to be involved in AKI. Here this study, we investigated the internal relation between ferroptosis and effect of VDR By using inhibitor ferrostatin-1 measurement ferroptotic cell death phenotype both vivo vitro AKI model, observed decreased blood urea nitrogen, creatinine, tissue by ferrostatin-1, hence...
This study aims to explore the effect of hypertension on disease progression and prognosis in patients with coronavirus 2019 (COVID-19). A total 310 diagnosed COVID-19 were studied. comparison was made between two groups patients, those without hypertension. Their demographic data, clinical manifestations, laboratory indicators, treatment methods collected analyzed. including 113 197 hypertension, included analysis. Compared older, more likely have diabetes cerebrovascular disease, be...
Objective: To explore and analyze the possible mechanism of liver injury in patients with coronavirus disease 2019 (novel pneumonia, NCP). Methods: The correlation between ALT, AST other enzyme changes condition NCP patients' status reported literature was comprehensively analyzed. ACE2 expression tissue for novel analyzed based on single cell sequencing (GSE115469) data. RNA-Seq method used to Ace2 transcription factors related its tissues at various time-points after hepatectomy mouse...
Standard quantum theory was formulated with complex-valued Schrödinger equations, wave functions, operators, and Hilbert spaces. Previous work attempted to simulate systems using only real numbers by exploiting an enlarged space. A fundamental question arises: are the complex really necessary in standard formalism of theory? To answer this question, a game has been developed distinguish from its real-number analog, revealing contradiction between high-fidelity multiqubit experiment players...
Fractional quantum Hall (FQH) states, known for their robust topological order and the emergence of non-Abelian anyons, have captured significant interest due to appealing applications in fault-tolerant computing. Bottom-up approach on an engineered platform will provide opportunities operate FQH states without external magnetic field enhance local coherent manipulation these exotic states. Here we demonstrate a lattice version photon state using programmable on-chip based blockade...
Background— Recent studies validated the measurement of left ventricular (LV) untwisting rate (UR) by speckle tracking echocardiography. A few reports suggest that it may provide additional noninvasive insight into LV diastolic function. Methods and Results— Simultaneous echocardiographic imaging pressure measurements (7F Millar catheters) were performed in 8 adult dogs. Loading conditions altered caval occlusion, whereas lusitropic state was changed dobutamine esmolol infusion. Inferior...
OBJECTIVE. This study aims to assess correlations of the time from symptom onset diagnosis and treatment with disease resolution CT scores as based on findings sequential chest examinations. MATERIALS AND METHODS. Thirty patients coronavirus (COVID-19) confirmed by reverse transcription-polymerase chain reaction analysis underwent Five who did not have positive or had yet fulfilled criteria for discharge hospital were excluded. determined according lung involvement. The was recorded each...
Anyons are quasiparticles occurring in two dimensions, whose topological properties believed to be robust against local perturbations and may hold promise for fault tolerant quantum computing. Here we present an experiment of demonstrating the path independent nature anyonic braiding statistics with a superconducting circuit, which represents 7-qubit version toric code model. We dynamically create ground state model, achieving fidelity $0.688\ifmmode\pm\else\textpm\fi{}0.015$ as verified by...
Diabetic nephropathy (DN) has become a major cause of end-stage renal disease, and autophagy disorder is implicated in the pathogenesis DN. Our previous studies found that vitamin D (VD) VDR (vitamin receptor) played renoprotective role by inhibiting inflammation fibrosis. However, whether VD-VDR regulates disorders DN remains unclear. In this study, we established streptozotocin (STZ)-induced diabetic model vdr knockout (vdr-KO) mice specifically overexpressed proximal tubular epithelial...
Abstract One of the major challenges potassium‐ion hybrid capacitors (PIHCs) is to explore favorable anode materials with fast reaction kinetics match cathodes. Here, an “inner‐surface” controlled electrochemistry mechanism based on bismuth electrode proposed and in‐depth studied, which different from capacitive or diffusion electrode. Such inner‐surface performance gives a high K ion ability under not only room temperature (RT) but also low (LT). In this study, kind conjunct‐like...
Importance Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in circulation alleviate symptoms patients with generalized MG. Objective To examine efficacy safety profile of batoclimab, a monoclonal IgG1 antibody, Design, Setting, Participants This was multicenter randomized clinical trial conducted from September 15,...
This study aimed to assess the effect and mechanism of SS31 on cisplatin-induced acute kidney injury (CP-AKI) both in vivo vitro. Male mices HK-2 cells were treated using cisplatin establish models CP-AKI. 32 C57BL/6 randomly divided into four groups (control group, CP + normal saline SS-31 group). Cisplatin was intraperitoneally injected once mice (25 mg/kg). administrated for 10 days at dosages mg/kg per day. Kidney histological changes level reactive oxygen species(ROS) detected. In vitro...
Adiabatic quantum computing enables the preparation of many-body ground states. Realization poses major experimental challenges: Direct analog implementation requires complex Hamiltonian engineering, while digitized version needs deep gate circuits. To bypass these obstacles, we suggest an adiabatic variational hybrid algorithm, which employs short circuits and provides a systematic optimization circuit parameters. The theorem promises not only state but also that excited eigenstates can be...
A central task towards building a practical quantum computer is to protect individual qubits from decoherence while retaining the ability perform high-fidelity entangling gates involving arbitrary two qubits. Here we propose and demonstrate dephasing-insensitive procedure for storing processing information in an all-to-all connected superconducting circuit multiple frequency-tunable qubits, each of which can be controllably coupled any other through bus resonator. Although it generally...
Hepatocyte proliferation could result in the loss of covalently closed circular DNA (cccDNA) and emergence cccDNA-cleared nascent hepatocytes, which appear refractory to hepatitis B virus (HBV) reinfection with unknown mechanism(s). Sodium taurocholate cotransporting polypeptide (NTCP) is functional receptor for HBV entry. In this study, down-regulation cell membrane localized NTCP expression proliferating hepatocytes was found prevent infection HepG2-NTCP-tet cells liver-humanized mice....
d-Allose is a low-calorie rare sugar with great application potential in the food and pharmaceutical industries. The production of d-allose has been accomplished using l-rhamnose isomerase (L-RI), but concomitantly increasing enzyme's stability activity remains challenging. Here, we rationally engineered an L-RI from Clostridium stercorarium to enhance its by comprehensive computation-aided redesign flexible regions, which were successively identified molecular dynamics simulations....
Increasing evidence shows that DNA methylation is involved in the development and progression of diabetes mellitus (DM) its complications. Previous studies conducted by our group have indicated high glucose levels may induce demethylation process connective tissue growth factor (CTGF) gene promoter increase expression CTGF human glomerular mesangial cells. Based on these findings, aim present study was to investigate level genomic patients with type 2 DM analyze possible correlation...