A5100339542- Tendon Structure and Treatment
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Corneal Surgery and Treatments
- Crystallization and Solubility Studies
- Periodontal Regeneration and Treatments
- X-ray Diffraction in Crystallography
- Wound Healing and Treatments
- Ocular Surface and Contact Lens
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Corneal surgery and disorders
- Cellular Mechanics and Interactions
- Antimicrobial Peptides and Activities
- Sports injuries and prevention
- Tissue Engineering and Regenerative Medicine
- Spine and Intervertebral Disc Pathology
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Hernia repair and management
- 3D Printing in Biomedical Research
- Cervical and Thoracic Myelopathy
- Hydrogels: synthesis, properties, applications
- Liver physiology and pathology
Southeast University
2019-2025
Zhongda Hospital Southeast University
2024-2025
Guiyang Medical University
2024-2025
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2024-2025
Guangdong Pharmaceutical University
2025
University of British Columbia
2024
Second Xiangya Hospital of Central South University
2023-2024
Xuzhou Medical College
2024
Central South University
2023-2024
Shandong First Medical University
2020-2024
Silk fibroin (SF) and sericin (SS), the two major proteins of silk, are attractive biomaterials with great potential in tissue engineering regenerative medicine. However, their biochemical interactions stem cells remain unclear. In this study, multiomics employed to obtain a global view cellular processes pathways mesenchymal (MSCs) triggered by SF SS discern cell-biomaterial at an in-depth, high-throughput molecular level. Integrated RNA sequencing proteomic analysis confirm that initiate...
Tendon stem/progenitor cells (TSPCs) were recently identified within tendon tissues. The aim of this study was to investigate TSPC-seeded knitted silk—collagen sponge scaffold for functional shoulder repair. multidifferentiation potential, proliferation, and immune properties TSPCs investigated in vitro, while the efficacy scaffolds promoting rotator cuff regeneration evaluated vivo a rabbit model. TSPCs, which exhibited universal stem cell characteristics (i.e., clonogenicity, high...
Nestin defines a novel tendon stem/progenitor cell subpopulation with high tenogenesis potential.
As tendon stem/progenitor cells were reported to be rare in tissues, tendons as vulnerable targets of sports injury possess poor self-repair capability. Human ESCs (hESCs) represent a promising approach regeneration. But their teno-lineage differentiation strategy has yet defined. Here, we report that force combined with the tendon-specific transcription factor scleraxis synergistically promoted commitment hESCs tenocyte for functional tissue Force and can independently induce...
Abstract Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain the short-term but often leads to osteoarthritis (OA) long-term. In this study, we report a new strategy of articular cartilage protection by intra-articular injection novel human meniscus stem/progenitor cells (hMeSPCs). We found that hMeSPCs displayed both mesenchymal stem cell characteristics and high expression levels collagen II. rat...
Osteochondral defects (OCD) cannot be efficiently repaired due to the unique physical architecture and pathological microenvironment including enhanced oxidative stress inflammation. Conventional strategies, such as control of implant microstructure or introduction growth factors, have limited functions failing manage these complex environments. Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes (CuTA@SF) provide suitable for OCD...
Abstract Osteochondral defects are characterized by injuries to both cartilage and subchondral bone, which is a result of trauma, inflammation, or inappropriate loading. Due the unique biological properties bone cartilage, developing tissue engineering scaffold that can promote dual‐lineage regeneration simultaneously remains great challenge. In this study, microporous nanosilicate‐reinforced enzymatically crosslinked silk fibroin (SF) hydrogel fabricated introducing montmorillonite (MMT)...
In osteochondral defects, oxidative stress caused by elevated levels of reactive oxygen species (ROS) can disrupt the normal endogenous repair process. this study, a multifunctional hydrogel composed silk fibroin (SF) and tannic acid (TA), FDA-approved ingredients, was developed to alleviate enhance regeneration. proposed hydrogel, SF first interacts with TA form hydrogen-bonded supramolecular structure, which is subsequently enzymatically crosslinked stable hydrogel. Furthermore, had...
Importance Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in circulation alleviate symptoms patients with generalized MG. Objective To examine efficacy safety profile of batoclimab, a monoclonal IgG1 antibody, Design, Setting, Participants This was multicenter randomized clinical trial conducted from September 15,...
Myotendinous junction (MTJ) injuries are prevalent in clinical practice, yet the treatment approaches limited to surgical suturing and conservative therapy, exhibiting a high recurrence rate. Current research on MTJ tissue engineering is scarce lacks vivo evaluation of repair efficacy. Here, we developed three-dimensional-printed bioactive fiber-reinforced hydrogel containing mesenchymal stem cells (MSCs) Klotho for structural functional regeneration. In rat defect model, promoted...
It is unknown whether transforming growth factor beta1 (TGF-beta1) signaling uniformly participates in fibrogenic chronic liver diseases, irrespective of the underlying origin, or if other cytokines such as interleukin (IL)-13 share fibrogenesis (e.g., due to regulatory effects on type I pro-collagen expression). TGF-beta1 events were scored 396 tissue samples from patients with diverse including hepatitis B virus (HBV), C (HCV), Schistosoma japonicum infection, and...
Despite our previous study that demonstrates human embryonic stem cells (hESCs) can be used as seed for tendon tissue engineering after stepwise induction, suboptimal regeneration implies a new strategy needs to developed repair. We investigated whether overexpression of the tendon-specific transcription factor scleraxis (SCX) in hESC-derived mesenchymal (hESC-MSCs) together with knitted silk-collagen sponge scaffold could promote regeneration.hESCs were initially differentiated into MSCs...
Abstract High concentration of ascorbic acid (vitamin C) has been found in corneal epithelium various species. However, the specific functions and mechanisms repair are not clear. In this study, it was that accelerates epithelial wound healing vivo mouse. addition, enhanced stemness cultured mouse stem/progenitor cells (TKE2) vitro, as shown by elevated clone formation ability increased expression markers (especially p63 SOX2). The contribution on enhancement dependent promotion Akt...
Endogenous repair of osteochondral defect is usually limited by the insufficient number cells in early stage and incomplete cell differentiation later stage. The development drug delivery systems for sequential release pro-migratory pro-chondrogenic molecules to induce endogenous bone marrow-derived mesenchymal stem (BMSCs) recruitment chondrogenic highly desirable situ regeneration. In this study, a novel, all-silk-derived system was fabricated incorporating tunable drug-loaded silk fibroin...