A5100362770- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Anorectal Disease Treatments and Outcomes
- Endometriosis Research and Treatment
- IL-33, ST2, and ILC Pathways
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Galectins and Cancer Biology
- Vector-borne infectious diseases
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Stoma care and complications
- Chemical Synthesis and Analysis
- Cancer-related molecular mechanisms research
- Cardiac electrophysiology and arrhythmias
- Plant-based Medicinal Research
- Pancreatitis Pathology and Treatment
- Acupuncture Treatment Research Studies
Baylor College of Medicine
2024-2025
Wuhan University
2025
Hubei University
2023-2025
Duke University
2025
Central Hospital of Zibo
2025
Shandong University
2022-2025
Zhongnan Hospital of Wuhan University
2025
Shandong Province Health and Family Planning Commission
2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Objective Creeping fat, the wrapping of mesenteric fat around bowel wall, is a typical feature Crohn’s disease, and associated with stricture formation obstruction. How creeping forms unknown, we interrogated potential mechanisms using novel intestinal tissue cell interaction systems. Design Tissues from normal, UC, non-strictured strictured disease specimens were obtained. The muscularis propria matrisome was determined via proteomics. Mesenteric explants, primary human preadipocytes...
Circular RNA (circ)_0000326 has been reported in bladder cancer and cervical is concerned to be involved with the development of cancerous cells.Whereas, there have no reports concentrating on influences circ_0000326 breast (BC).Therefore, latent modulatory mechanisms BC are researched.circ_0000326 expression tissues correlative cells was evaluated via RT-qPCR, relevance between overall survival clinicopathological feature also investigated.After a series transfection, effects circ_0000326,...
Recent studies have discovered that tiny particles of microplastics (MPs) at the nano-scale level can enter body organisms from environment, potentially causing metabolic ailments. However, further investigation is required to understand alterations in immune microenvironment associated with non-alcoholic fatty liver disease (NAFLD) occurrence following exposure MPs. Experiments were performed using mice, which given a normal chow or high-fat diet (NCD HFD, respectively) plus free drinking...
Importance Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in circulation alleviate symptoms patients with generalized MG. Objective To examine efficacy safety profile of batoclimab, a monoclonal IgG1 antibody, Design, Setting, Participants This was multicenter randomized clinical trial conducted from September 15,...
Objective Intestinal fibrosis is considered an inevitable consequence of chronic IBD, leading to stricture formation and need for surgery. During the process fibrogenesis, extracellular matrix (ECM) components critically regulate function mesenchymal cells. We characterised composition ECM in fibrostenosing Crohn’s disease (CD) control tissues. Design Decellularised full-thickness intestinal tissue platforms were tested using three different protocols, phenotypes was explored by proteomics...
Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) protect intervertebral disc degeneration (IDD) regulating nucleus pulposus cell (NPC) apoptosis. But the mechanism of BMSCs-EVs-microRNA (miR)-199a in IDD remains unclear. In this study, after acquisition and identification BMSCs BMSCs-EVs, mouse model was established treated with BMSCs-EVs. The pathological changes NPCs, positive expression MMP-2, MMP-6 TIMP1, senescence apoptosis NPCs were evaluated....
Abstract Mycoplasma pneumoniae necrotizing pneumonia (MPNP) has a long and severe disease course, which seriously threatens to jeopardize patients' lives health. Early prediction is essential for good recovery prognosis. In the present study, we retrospect 128 children with MPNP 118 e combined pulmonary consolidation explore predictive value of lactate dehydrogenase (LDH) in by propensity score matching method, multiple logistic regression analysis, dose–response analysis decision curve...
Black soldier fly (BSF) larvae convert wastes into protein, playing a vital role in addressing the challenge of sustainable poultry production. These accumulate toxic substances, posing risk to feed and food safety. This study investigates effects substituting soybean meal with different levels BSF on laying performance, egg quality, serum analysis, deposition various metals eggs, meat, excreta. A total 1,008 Lohmann hens (age 48 wk) were randomly assigned 4 treatments. The treatments...
Abstract Background: Paired-like homeodomain transcription factor 1 (PITX1) participates in miscellaneous biological processes including cell growth, development, progression and invasion various malignant tumors. However, the analysis of association between PITX1 expression survival breast cancer remains unclear. Methods: Clinical prognostic parameters data related to patients were performed using bioinformatic Oncomine, Bc-GenExMiner v4.3, PrognoScan UCSC Xena. Results: We found that gene...
Gray mold in pears, caused by Botrytis cinerea, leads to severe economic losses. We investigated the biocontrol of gray postharvest pear fruits using termite symbiont Streptomyces griseus H3950 and determined that S. effectively controlled pears. The control efficiency a total fermentation broth culture or cell (hyphae) was 78.38% 77.27%, respectively, at 2 days post inoculation. Scanning electron microscopy indicated competed with B. cinerea for nutrition space. Transcriptome analy-sis...
In mammalian cells, gene copy number is tightly controlled to maintain expression and genome stability. However, a common molecular feature across cancer types oncogene amplification, which promotes progression by drastically increasing the of tumor-promoting genes. For example, in tyrosine kinase inhibitor (TKI)-resistant lung adenocarcinoma (LUAD), amplification occurs over 40% patients' tumors. Despite prevalence TKI-resistant tumors, mechanisms facilitating are not fully understood....
Postoperative atrial fibrillation (poAF) is AF occurring days after surgery with a prevalence of 33% among patients undergoing open-heart surgery. The degree postoperative inflammation correlates poAF risk, but less known about the cellular and molecular mechanisms driving arrhythmogenesis. We performed single-cell RNA sequencing comparing non-myocytes from mice versus without poAF, which revealed infiltrating CCR2+ macrophages to be most altered cell type. Pseudotime trajectory analyses...
Erectile dysfunction is a common clinical condition that seriously affects the quality of life and mental health men their partners. Metabolic syndrome (MetS) most important public problem threatening men's worldwide, its current prevalence continues to grow. This study examines relationship between metabolic erectile (ED). We conducted cross-sectional with data were sourced from NHANES 2001-2004. In this study, METS-VF ED was analyzed using multivariate logistic regression, followed by...