A5083653826- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Ophthalmology and Visual Impairment Studies
- Alzheimer's disease research and treatments
- Sarcoma Diagnosis and Treatment
- Plant Molecular Biology Research
- Hormonal Regulation and Hypertension
- Corneal Surgery and Treatments
- Optical Coherence Tomography Applications
- Pharmacological Effects of Natural Compounds
- Trace Elements in Health
- Ocular Infections and Treatments
- Advanced Drug Delivery Systems
- Advanced Neuroimaging Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Neurological diseases and metabolism
- Plant Reproductive Biology
- Thyroid Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Analysis
Nanjing Agricultural University
2023-2025
Shandong Eye Hospital
2010-2021
Shandong First Medical University
2011-2021
Qingdao University
2016-2021
Southwest Jiaotong University
2021
Affiliated Hospital of Qingdao University
2021
Tianjin Medical University
1997-2015
Tianjin Medical University General Hospital
2014
Nanjing Medical University
2014
Peking University
2008-2012
Myricetin (Myr) is a naturally occurring flavonoid exhibiting diverse biological and pharmacological properties, but its characteristics such as water insolubility, poor aqueous stability, bioavailability limit clinical application, including in ophthalmology. To increase application ophthalmology, Myr was designed to be encapsulated polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG) polymeric micelles increases solubility, corneal permeability promote...
Abstract High concentration of ascorbic acid (vitamin C) has been found in corneal epithelium various species. However, the specific functions and mechanisms repair are not clear. In this study, it was that accelerates epithelial wound healing vivo mouse. addition, enhanced stemness cultured mouse stem/progenitor cells (TKE2) vitro, as shown by elevated clone formation ability increased expression markers (especially p63 SOX2). The contribution on enhancement dependent promotion Akt...
CYP78A, a cytochrome P450 subfamily that includes rice (Oryza sativa L.) BIG GRAIN2 (BG2, CYP78A13) and Arabidopsis thaliana KLUH (KLU, CYP78A5), generate an unknown mobile growth signal (referred to as CYP78A-derived signal) increases grain (seed) size. However, the mechanism by which CYP78A pathway size remains elusive. Here, we characterized small mutant, grain4 (smg4), with smaller grains than its wild type due restricted cell expansion proliferation in spikelet hulls. SMG4 encodes...
ABSTRACT Grain size is a key determinant of 1,000‐grain weight, one three factors determining grain yield. However, the complete regulatory network controlling has not been fully clarified. Here, we identified rice mutant, named small and round ( srg ) that exhibits semi‐dwarf stature size. Cytological analysis showed cell length number spikelet epidermal cells mutant are reduced, indicating SRG controls by promoting elongation increasing number. encodes kinesin belonging to kinesin‐1...
The aim was to develop a nanocarrier based on polyoxyl 15 hydroxystearate (Kolliphor® HS15, HS15) micelles for the solubility, stability, and ocular delivery of myricetin (Myr). An optimized ratio HS15 Myr prepared fabricate HS15-Myr micelle ophthalmic solution. Myr-encapsulating (HS15-Myr micelles) were subjected physicochemical characterizations. chemical stability in storage solutions evaluated. In vitro parallel artificial membrane permeability assay antioxidant activity also measured....
Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within might strengthen drug's therapeutic action reduce side effects.Diclofenac-loaded (Rb1-Dic micelles) were formulated, optimized, then further evaluated for vitro cytotoxicity/in vivo irritation, corneal permeation, anti-inflammatory efficacy.Rb1 self-assembled into with ultra-small particle...
in vitro, it has been reported that amyloid β (Aβ) is bound to red blood cells (RBCs) and this process damages the cell. Also, a possible relationship between RBCs Alzheimer's disease (AD) supported by findings of RBC impairment AD. Therefore, Aβ fibrils bounding are great interest as potential biomarkers.in study, we focused on and/or aggregation peripheral from 50 subjects with AD healthy controls (HCs) through thioflavin T (ThT) staining followed immunofluorescence assay confirm presence...
Abstract Background The recurrence rate of chordoma is high, and the prognosis poor. Methods Differential proteomic analysis was performed on chordomas adjacent normal tissues, with verification by Western blot. Protein expression evaluated immunohistochemistry 37 chordomas. Association candidate protein clinical parameters, disease‐free survival, overall survival were analyzed. Results We identified 14 up‐regulated 5 down‐regulated proteins in Expression alpha enolase (ENO1), pyruvate...
Ischemic stroke is one of the major diseases with high morbidity, mortality, and disability rate all over world. Chinese herb-derived active components would provide valuable candidate compounds for ischemic therapy. Paeoniflorin (PF) an ingredient from Paeoniae Radix which possesses neurovascular effect after ischemia. However, so far, few studies are reported on efficacy mechanism PF angiogenesis aspects. Results our in vitro showed that ability proliferation, migration, tube formation...
To evaluate clinical efficacy and safety of single Ultrasound Cyclo-Plasty (UCP) in the treatment advanced refractory glaucoma.From January 2018 to August 2018, 25 patients (25 eyes) with glaucoma intraocular pressure (IOP) not controlled by drugs or conventional filtering surgery were included study. All subjects (neovascular [n = 12], secondary 6], angle closure primary open 1]) underwent 8-sector Cyclo-Plasty. Patients followed-up at Day 1, Week 3, 6, 12 months, during which IOP, number...
Abstract Background Giant cell tumor of bone (GCTB) is an aggressive benign with poor prognosis whose neoplastic component stromal cells (SCs). Tumor stem‐like (TSCs) have been demonstrated as precursors for genesis and growth. The aim this study to identify TSCs in GCTB. Methods Stro‐1 + − were isolated by fluorescence‐activated sorting (FACS). Stem‐like properties both subpopulations assessed using MTT colorimetric assays, cycle analyses, sphere formation differentiation assays. Molecular...
AIM: To investigate the association of axial length (AL), lens thickness (LT), and vault (LV) with postoperative anterior chamber angle metrics after laser peripheral iridotomy (LPI). METHODS: Prospective observational study 69 patients (97 eyes) were diagnosed as primary angle-closure suspect (PACS), closure (PAC) or glaucoma (PACG). AL, LT, central depth (ACD), opening distance (AOD), trabecular iris (TIA), recess area (ARA) measured before 1wk LPI. The between LV ACD, AOD, TIA, ARA...
To compare the visual functional outcomes with accommodating and multifocal intraocular lenses (IOLs).Our retrospective comparative study included 51 patients (60 eyes) received implantation of an IOL (Tetraflex; 16 patients, 20 eyes), a refractive (ReZoom; 18 or diffractive (ZMA00; 17 eyes). Subjective refraction, acuity, contrast sensitivity (CS), aberration, subjective photic phenomena were detected at 3mo after surgery.The spherical equivalent in three groups was -0.38±0.54 D, 0.14±0.56...
Objective To study the conjunctival bacteria flora in eyes of patients undergoing cataract surgery and determine efficacy reducing with different methods. Methods A total 135 scheduled to undergo were randomized into 3 groups (45 each). They received topical prophylactic treatment three kinds antibiotics (0.5% levofloxacin, 0.3% levofloxacin tobramycin). Each group was one-day three-day group. All underwent irrigation fornices 2.5% povidone-iedine (PVI) before surgery. Conjunctival cultures...
Introduction: The hypertensive double-transgenic (dTG) rat strain, expressing human renin and angiotensinogen, develops severe hypertension organ damage 50% of individuals die by 7 weeks age. Here, we characterise a variation this model in which animals present stable hypertension. Materials methods: effect renin—angiotensin system blockers on blood pressure was determined with adult dTG rats treated enalapril from 3 to 12 Tissue expression levels angiotensinogen were rhesus monkeys...
The aim of this work was to evaluate the narrow anterior chamber angle (ACA) in Chinese patients by segment optical coherence tomography (As-OCT).Eighty right eyes 80 consecutive with a shallow peripheral but no synechia were enrolled study. ACA observed noncompression gonioscopy and classified according Shaffer grading system. iridotrabecular contact (ITC) trabecular-iris (T-I angle) assessed As-OCT examination.Gonioscopic grade 0 ITC more frequently superior quadrant than other quadrants...