A5067682401- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Myasthenia Gravis and Thymoma
- Mitochondrial Function and Pathology
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Pharmacological Effects and Toxicity Studies
- Autophagy in Disease and Therapy
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- RNA regulation and disease
- Clinical Nutrition and Gastroenterology
- Autoimmune Neurological Disorders and Treatments
- S100 Proteins and Annexins
- Organ Transplantation Techniques and Outcomes
- Cell Adhesion Molecules Research
- Neurological diseases and metabolism
- Glycogen Storage Diseases and Myoclonus
- Neurogenesis and neuroplasticity mechanisms
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Renal Transplantation Outcomes and Treatments
- Neurological and metabolic disorders
- Antifungal resistance and susceptibility
Chongqing Medical University
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Daping Hospital
2023-2024
Army Medical University
2023-2024
Shanghai Jiao Tong University
2024
Urology Team
2023
Guiyang Medical University
2023
Yidu Central Hospital of Weifang
2023
Weifang Medical University
2023
Sichuan University
2021
We have previously shown that serum insulin levels decrease threefold and blood glucose remain normal in mice fed a leucine-deficient diet, suggesting increased sensitivity. The goal of the current study is to investigate this possibility elucidate underlying cellular mechanisms.Changes metabolic parameters expression genes proteins involved regulation sensitivity were analyzed mice, human HepG2 cells, mouse primary hepatocytes under leucine deprivation.We show deprivation improves hepatic...
Importance Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in circulation alleviate symptoms patients with generalized MG. Objective To examine efficacy safety profile of batoclimab, a monoclonal IgG1 antibody, Design, Setting, Participants This was multicenter randomized clinical trial conducted from September 15,...
Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, yet effective treatment lacking. Moreover, underlying pathomechanisms ALS remain unclear, with impaired mitophagy function being increasingly recognized as a contributing factor. FUN14 domain-containing protein 1 (FUNDC1) an autophagy receptor localized to outer mitochondrial membrane and that mediates therefore considered important factor in diseases. However, its specific role not clear. Therefore,...
To elucidate the molecular basis of intractable epilepsy (IE), we used a whole-genome transcriptomic approach to identify genes involved in pathogenesis this disease. Using complementary DNAs microarray representing 4096 human genes, analyzed differential gene expression anterior temporal neocortex (ATN) IE patients relative control who had an operation relieve head trauma-related intracranial pressure. The results were validated by real-time fluorescence-quantitative polymerase chain...
Epilepsy is a widespread neurological disorder affecting more than 65 million people, but the mechanisms of epilepsy remains unknown. Abnormal synaptic transmission has crucial role in occurrence and development epilepsy. Here, we found that syntabulin, neuronal transporter, was mainly localized neurons, its expression increased epileptic tissues. Knockdown syntabulin susceptibility severity epilepsy, whereas overexpression had opposite effect. Mechanistically, brain tissue, translocated...
Abstract Tubulin β‐ III ( TUBB3 ) is the most dynamic β‐tubulin isoform expressed in neurons, and highly central nervous system. However, relationship between epileptic seizures has not been thoroughly investigated. The aims of this study were to investigate expression patients with temporal lobe epilepsy two different rat models chronic epilepsy, determine specific roles epilepsy. was upregulated human tissue. Moreover, associated inhibitory GABAergic neurons postsynaptic scaffold protein...
The expression of the transmembrane protein 25 gene (Tmem25) is strongly influenced by glutamate ionotropic receptor kainate type subunit 4, and its function remains unknown. Here, we showed that TMEM25 was primarily localized to late endosomes in neurons. Electrophysiological experiments suggested effects on neuronal excitability were likely mediated N-methyl-d-aspartate receptors. affected NR2B interacted with NR2B, both colocalized endosome compartments. induced acidification changes...
Epilepsy is one of the most common chronic neurological diseases in world, with a high incidence, risk sudden unexplained death, and diagnostic challenges. Exosomes are nanosized extracellular vesicles that released into physical environments carry variety biological information. Moreover, exosomes can also be synthesized from brain cells, passing through blood-brain barrier, detected peripheral blood or cerebrospinal fluid. Our study using tandem mass tag (TMT) approach showed total 76...
<i>Aim:</i> To evaluate the efficacy and safety of 3,000 mg daily levetiracetam (LEV; Keppra) as an adjunctive therapy for Chinese patients with refractory partial seizures. <i>Methods:</i> This randomized, placebo-controlled trial consisted 8-week baseline period followed by a 4-week titration interval 12-week maintenance period, concluded medication withdrawal or entered open-label study. LEV was compared placebo. <i>Results:</i> The 50% responder rate...
BACKGROUND Severe fever with thrombocytopenia syndrome (SFTS) is a zoonotic viral hemorrhagic caused by the SFTS virus (SFTSV), which newly identified tick-borne bunyavirus, recently named Dabie bandavirus. In rural China, SFTSV or bandavirus commonly transmitted Haemaphysalis longicornis, Asian longhorned tick. recent years, has been of great concern due to its high morbidity and mortality. The present study investigated risk factors for mortality in patients complicated central nervous...
Abstract The pathophysiological mechanisms underlying epileptogenesis are poorly understood but considered to actively involve an imbalance between excitatory and inhibitory synaptic transmission. Excessive activation of autophagy, a cellular pathway that leads the removal proteins, is known aggravate disease. Toll-like receptor (TLR) 7 innate immune regulates autophagy in infectious noninfectious diseases. However, relationship TLR7, transmission during remains unclear. We found TLR7 was...
The pathogenesis of epilepsy remains unclear; however, a prevailing hypothesis suggests that the primary underlying cause is an imbalance between neuronal excitability and inhibition. Glucose-6-phosphate dehydrogenase (G6PD) key enzyme in pentose phosphate pathway, which primarily involved deoxynucleic acid synthesis antioxidant defense mechanisms exhibits increased expression during chronic phase epilepsy, predominantly colocalizing with neurons. G6PD overexpression significantly reduces...
Extracellular signal‐regulated kinases (ERK) such as ERK1 [p44 mitogen‐activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the central nervous system under physiological pathological conditions ischemia epilepsy. Our aim is to investigate ERK1, ERK2, phosphorylated ERK (p‐ERK) (Thr202/Tyr 204) expression temporal lobe of patients with intractable epilepsy (IE) explore its possible role it. Tissue samples from neocortices 40 who had surgery for IE were used detect p‐ERK (Thr...