A5070407653- Salivary Gland Disorders and Functions
- Genomics and Chromatin Dynamics
- COVID-19 Clinical Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Chemokine receptors and signaling
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Research Studies
- Autophagy in Disease and Therapy
- Psoriasis: Treatment and Pathogenesis
- Pluripotent Stem Cells Research
- Lung Cancer Treatments and Mutations
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Circular RNAs in diseases
Chongqing University of Technology
2025
Tsinghua University
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2020-2024
Culture Resource
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
The First Hospital of Kunming
2024
Second Affiliated Hospital of Zhejiang University
2024
Chongqing University
2024
Backgrounds Diabetic retinopathy (DR), especially proliferative diabetic (PDR), is the major cause of irreversible blindness in working-age population. Increasing evidence indicates that immune cells and inflammatory microenvironment play an important role during PDR development. Herein, we aim to explore landscape then identify potential biomarkers correlated with specific infiltrating cells. Methods We mined re-analyzed PDR-related datasets from Gene Expression Omnibus (GEO) database....
Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, yet effective treatment lacking. Moreover, underlying pathomechanisms ALS remain unclear, with impaired mitophagy function being increasingly recognized as a contributing factor. FUN14 domain-containing protein 1 (FUNDC1) an autophagy receptor localized to outer mitochondrial membrane and that mediates therefore considered important factor in diseases. However, its specific role not clear. Therefore,...
Ferroptosis plays an extremely significant role in the development of hepatocellular carcinoma (HCC), and targeting tumor cells to induce ferroptosis has emerged as a new approach for treatment cancer.
Silent information regulator sirtuin 1 (SIRT1) is a niacinamide adenine dinucleotide (NAD)-dependent histone deacetylase and promising target for the treatment of hepatocellular carcinoma (HCC).
Abstract Asiaticoside (AS) has been reported to have protective effect on pulmonary fibrosis (PF). In this study, we aimed explore the potential mechanism of therapeutic role AS and its relationship with A2AR in PF. Adenosine 2A receptor gene knockout (A2AR −/− ) mice wild‐type (WT) were used establish bleomycin (BLM)‐induced PF models then treated (50 mg/kg/d). Pulmonary inflammation observed model much higher severity than that WT significantly alleviated lung fibrosis; however, it was...
Abstract Objective To investigate distinct features of renal involvement in patients with primary Sjögren’s syndrome (pSS) and to identify potential factors associated involvement. Methods Four hundred thrity‐four pSS from the Rheumatology Department First Affiliated Hospital Wenzhou Medical University 2013 2017 were included a cross‐sectional study. Patients compared their age‐ gender‐matched controls (pSS without involvement). Demographic, clinical, histological, nephritic, immunological...
Abstract Aging is characterized by the loss of homeostasis and general decline physiological functions, accompanied various degenerative diseases increased rates mortality. targeting small molecule screens have been performed many times, however, few focused on endogenous metabolic intermediates—metabolites. Here, using C. elegans lifespan assays, we conducted a worm metabolite screen identified an eukaryotes conserved metabolite, myo -inositol (MI), to extend lifespan, increase mobility...
Cyclin-dependent kinase inhibitor 2C (CDKN2C) was identified to participate in the occurrence and development of multiple cancers; however, its roles small cell lung carcinoma (SCLC) remain unclear.Differential expression analysis CDKN2C between SCLC non-SCLC were performed based on 937 samples from centers. The prognosis effects patients with detected using both Kaplan-Meier curves log-rank tests. Using receiver-operating characteristic curves, whether made it feasible distinguish...
Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by exocrine gland damage and extraglandular involvements. To identify potential biomarkers for the early detection of pSS to further investigate roles in progression pSS, our previous RNA sequencing data four microarray salivary glands (SGs) were combined integrative transcriptome analysis between non-pSS. Differential gene expression analysis, co-expression network pathway conducted detect hub genes,...
Investigate the effect of long-term COVID-19 on maternal and fetal complications. A retrospective cohort study was conducted. total 623 pregnant women who delivered in Kunming First People's Hospital from November 1, 2022 to July 31, 2023 were selected. By employing statistical methods, we compared associations between complications with acute during pregnancy, COVID-19, non-COVID-19 women. In final samples, there 209 72 342 without COVID-19. The epidemiological clinical characteristics all...
Abstract Background Pulmonary arterial hypertension (PAH) is a life-threatening condition. The aim of this study was to explore potential crucial genes and pathways associated with PAH based on integrative analyses gene expression shed light the identification biomarker for PAH. Methods Gene profile pulmonary tissues from 27 patients 22 normal controls were downloaded public database (GSE53408 GSE113439). After differentially expressed (DEGs), hub identified comprehensive evaluation...
Early-onset Schizophrenia (EOS) is a profoundly progressive psychiatric disorder characterized by both positive and negative symptoms, whose pathogenesis influenced genes, environment brain structure development. In this study, the MIND (Morphometric Inverse Divergence) network was employed to explore relationship between morphological similarity specific transcriptional expression patterns in EOS patients. This study involved cohort of 187 participants aged 7 17 years, consisting 97...
First-episode schizophrenia (FES) is a progressive psychiatric disorder influenced by genetics, environmental factors, and brain function. The functional gradient deficits of drug-naïve FES its relationship to gene expression profiles treatment outcomes are unknown.
Major salivary gland ultrasonography (SGUS) is increasingly being recognized as having critical roles in differentiating primary Sjögren's syndrome (pSS) from other connective tissue disorders. Contrast-enhanced (CEUS) has been reported to evaluate microvascularity of lesions different tissues with objective angiographic index, eliminating the observer-dependent defect ultrasonography. However, there are few relevant studies concentrating on application CEUS diagnosis and assessment for pSS,...
Type-A aortic dissection (TAAD) is common life-threatening cardiovascular diseases with high-morbidity and mortality but the concrete etiology of disease remains unclear, which might disturb or delay early diagnosis for TAAD. Anoikis a special form programmed cell-death (PCD) induced by detachment anchorage-dependent cells from extracellular matrix (ECM) neighboring cells, has been widely applied to identify anoikis-related biomarkers prediction prognosis in oncological fields. However,...