A5101585779- Land Use and Ecosystem Services
- Cancer-related molecular mechanisms research
- Urban Green Space and Health
- Coastal wetland ecosystem dynamics
- Constructed Wetlands for Wastewater Treatment
- Circular RNAs in diseases
- Meta-analysis and systematic reviews
- Cardiac, Anesthesia and Surgical Outcomes
- Reproductive Biology and Fertility
- Corneal surgery and disorders
- Extracellular vesicles in disease
- RNA modifications and cancer
- Renal and related cancers
- Urban Stormwater Management Solutions
- 3D Modeling in Geospatial Applications
- Epigenetics and DNA Methylation
- Appendicitis Diagnosis and Management
- Aortic aneurysm repair treatments
- RNA Research and Splicing
- Urban Heat Island Mitigation
- Aortic Disease and Treatment Approaches
- Ecology and Conservation Studies
- ATP Synthase and ATPases Research
- Wildlife-Road Interactions and Conservation
- Signaling Pathways in Disease
Beijing Friendship Hospital
2022-2025
Capital Medical University
2022-2025
Zhejiang University of Technology
2022-2024
Zhejiang Sci-Tech University
2024
Tsinghua University
2022-2023
Beijing Tsinghua Chang Gung Hospital
2023
Shanghai University
2022
First Affiliated Hospital of Kunming Medical University
2021
Kunming Medical University
2021
Peking University
2015-2018
Mitochondrial diseases are maternally inherited heterogeneous disorders that primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, defects can result in a wide spectrum clinical manifestations. Mitochondria-targeted endonucleases provide an alternative avenue for treating via targeted destruction mtDNA and induction heteroplasmic shifting. Here, we generated disease patient-specific induced pluripotent stem cells...
Abstract Development of distant metastasis is the main cause deaths in prostate cancer (PCa) patients. Understanding mechanism PCa utmost importance to improve its prognosis. The role exosomal long noncoding RNA (lncRNA) has been reported not yet fully understood PCa. Here, we discovered an lncRNA HOXD-AS1 upregulated castration resistant (CRPC) cell line derived exosomes and serum from metastatic patients, which correlated with tissue expression. Further investigation confirmed promotes...
Abstract For typical wastewater treatment processes of urban sewage, plants are often noneffective to improve water qualities lightly polluted domestic and constructed quality (WQT) wetlands designed with engineering landscape methods utilized optimize both values in recent years. The research determines the effects two ecological landscaping projects WQT by analysing their improvements. Differences indicators (WQI) respectively among different stages includes surface flow wetland, vertical...
Abstract The immune response to hepatitis B vaccination varies among individuals. It has been reported that polymorphisms in cytokine and receptor genes are associated with these individual differences. aim of the current study was investigate association between Th1/Th2 a Chinese Han population. A total 10 single nucleotide distributed 6 (TNFRSF1A, IL12A, IL12B, IFNG, IL4, IL10) were genotyped 214 high‐responders [hepatitis surface antibody (anti‐HBs) ≥1,000 mIU/ml] 107 low‐responders...
Although geodesign techniques have been studied and developed worldwide, there is still a lack of in-depth application workflows for redesigning urban river wetlands with characteristics ecologically engineered landscaping (EEL). The study mainly aims at putting forward proper approach in the methodological foundation EEL practices wetlands. A typical EEL-oriented project restoration Hangzhou, China, was conducted this study. Based on in-situ geodata tools within QGIS, individual geological...
Abstract Endometrial cancer (EC), a widely occurring in the uterus, is among top four most frequent malignancies women. To improve approaches for combating this disease, it essential to gain more comprehensive comprehension of intricate causes EC. Accumulating evidence highlight role long non‐coding RNA (LncRNA) EC progression, while its biological and mechanical function has not been fully revealed. In study, LncRNA microarray analysis was performed using pairs paclitaxel (PTX) resistant...
Abstract Water environments of urban constructed water quality treatment (WQT) wetland waterscapes are strongly related to quality, whereas scenic beauty values help achieve better aquatic environments. However, correlations between several indicators (WQIs) and indexes (SBIs) have not been thoroughly revealed in the existing studies. In this research, an analytic hierarchy process (AHP)-based on estimation (SBE) per site two WQT wetlands has developed. The weights were determined by AHP...
Alpha-2-adrenergic receptor (ADRA2A) is involved in the sympathetic nervous system and plays a role regulation of insulin secretion lipolysis. Recent studies have indicated that ADRA2A polymorphisms are associated with type 2 diabetes (T2DM) Caucasians African Americans. The present study aimed to evaluate association between T2DM Chinese Han population. Two single-nucleotide (SNPs) rs521674 rs553668 gene were genotyped 2094 subjects (1042 patients 1052 nondiabetic controls) by using TaqMan...
Type-A aortic dissection (TAAD) is common life-threatening cardiovascular diseases with high-morbidity and mortality but the concrete etiology of disease remains unclear, which might disturb or delay early diagnosis for TAAD. Anoikis a special form programmed cell-death (PCD) induced by detachment anchorage-dependent cells from extracellular matrix (ECM) neighboring cells, has been widely applied to identify anoikis-related biomarkers prediction prognosis in oncological fields. However,...
Endometrial cancer (EC) is the gynecological tumor with highest incidence. In recent years, it has been proved that necroptosis a method of cell death related to EC. However, expression necroptosis-related miRNA in EC and its correlation prognosis still ill-defined. Use Cancer Genome Atlas (TCGA) cohort obtain prognostic data clinical for ECs normal endometrium tissues. this study, we identified three necroptotic regulatory miRNAs are survival-related (DENSMs) between tissues from 13 miRNAs....
Trophoblast stem cells differentiate into different trophoblast cell populations that are indispensable for successful pregnancy through interactions with the maternal uterine decidua. Rho GTPases play an important role in regulation of (TSC) self-renewal and differentiation; however, GDP-dissociation inhibitors (Rho GDIs) remains unclear. Here we report overexpression GDIalpha resulted rapid apoptosis TSCs, while its knockdown promoted proliferation. Moreover, also enhanced TSC invasion....
<title>Abstract</title> This study introduces a Landscape Information Modeling–Stable Diffusion (LIM–SD)-based digital workflow for ecological engineered landscaping (EEL) design, focusing on urban river wetlands. It explores how students from diverse academic backgrounds perform EEL tasks using the LIM–SD approach. A total of 30 participants, including industrial design postgraduates and landscape architecture undergraduates postgraduates, completed tasks. The efficacy their designs was...
Abstract Certain urban river riparian exhibit complex and diverse geomorphology, where environmental anthropogenic factors regularly impact plant diversity in the aquatic-land interface zones. This phenomenon has given rise to a distinctive ecosystem at confluence of aquatic terrestrial habitats. The study aims explore correlation between zones factors, encompassing water quality hydrology. Data were collected from 8 sites with 48 samples Yuhangtang River Basin Hangzhou, P. R. China, through...
In this paper, a new method is proposed for automatic edge detection of the front and back corneal contours in frame Sheimpflug images. First, we enhance contrast reduce noises including speckle eyelashes as preprocessing procedure. Then use phase symmetry asymmetry to get energy Finally, trace center line cornea then upper lower curves. We validated segmentation on series videos collected by department Chinese PLA General Hospital. The results shows that provides equivalent performance...
Abstract Ecological engineered landscaping (EEL) is a type of design work which incorporates various ecological principles and aims to provide aesthetic characteristics semi-natural environments. Digital landscape techniques, such as Landscape Information Modelling (LIM) Stable Diffusion (SD) -based approach, has significant potential support EEL projects for both environmental engineers architects. This study quantitatively evaluate the efficacy feasibility LIM-SD-based approach applied an...
<title>Abstract</title> Objectives To evaluate the effectiveness of four large language models (LLMs) (Claude, Bard, ChatGPT4, and New Bing) that have user bases significant social attention, in context medical consultation patient education urolithiasis. Materials methods In this study, we developed a questionnaire consisting twenty-one questions two clinical scenarios related to Subsequently, consultations were simulated for each assess their responses questions. Urolithiasis experts then...