A5103492762- Vitamin D Research Studies
- Natural product bioactivities and synthesis
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Traditional and Medicinal Uses of Annonaceae
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phytochemistry and Biological Activities
- Hepatitis C virus research
- Tea Polyphenols and Effects
- Alkaloids: synthesis and pharmacology
- Phytochemical compounds biological activities
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Ubiquitin and proteasome pathways
- Plant Diversity and Evolution
- Alcohol Consumption and Health Effects
- Morinda citrifolia extract uses
- Pharmacological Effects of Natural Compounds
- Nuclear Receptors and Signaling
- Vasculitis and related conditions
- Sesquiterpenes and Asteraceae Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Trigeminal Neuralgia and Treatments
- Diet and metabolism studies
- Spinal Cord Injury Research
China Medical University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Qiqihar Medical University
2024
Affiliated Hospital of North Sichuan Medical College
2024
Weatherford College
2024
Anhui University of Traditional Chinese Medicine
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
CD8 + T cell activation leads to the rapid proliferation and differentiation of effector cells (T effs ), which mediate antitumor immunity. Although aerobic glycolysis is preferentially activated in , mechanisms that regulate glucose uptake low-glucose acidic tumor microenvironment (TME) remain poorly understood. Here, we report abundance transporter GLUT10 increased during Specifically, deficiency inhibited uptake, glycolysis, efficiency tumor-infiltrating cells. Supplementation with alone...
Skin aging is categorized as chronological and photo-aging that affected by intrinsic extrinsic factors. The present study aimed to investigate the anti-aging ability its underlying mechanism of chlorogenic acid (CGA) on human dermal fibroblasts (HDFs). In this study, CGA specifically up-regulated collagen I (Col1) mRNA protein expressions increased secretion in supernatant HDFs without affecting cell viability, latter was also demonstrated BioMAP HDF3CGF system. Under ultraviolet A...
Rationale: Silicosis is a severe occupational lung disease. Current treatments for silicosis have highly limited availability (i.e., transplantation) or, do not effectively prolong patient survival time lavage). There thus an urgent clinical need effective drugs to retard the progression of silicosis. Methods: To systematically characterize molecular changes associated with and discover potential therapeutic targets, we conducted transcriptomics analysis human tissues acquired during...
Twenty-nine derivatives of berberine (1) or pseudoberberine (2) were designed, semisynthesized, and evaluated for their up-regulatory activity on the low-density-lipoprotein receptor (LDLR) expression. SAR analysis revealed that (i) methylenedioxy group at 2- 3-position is an essential element to keep activity, (ii) 7-position quaternary ammonium planar structure compound are activity-required, (iii) addition electron-donating groups 7- 13-position reduced activity. Of 1 analogues, 2...
Psychological problems are common among end-stage renal disease patients undergoing dialysis. We aim to evaluate whether high-dose vitamin D3 (VD3) supplementation has beneficial effects on depressive symptoms in dialysis patients. This prospective, randomized, and double-blind trial includes 746 with depression treated 3 hospitals Southeast China. Depression was diagnosed according the Diagnostic Statistical Manual of Mental Disorders criteria. Patients were randomly assigned 52-week...
Abstract Blocking p53 ubiquitination through disrupting its interaction with MDM2 or inhibiting the catalytic activity is central mechanism by which tumor suppressor activated in response to genotoxic challenges. Although first characterized as major E3 ubiquitin ligase for p53, it can also catalyze conjugation of moieties other proteins (e.g., activating transcription factor 3, ATF3). Here we report that ATF3 act an “trap” and competes MDM2-mediated ubiquitination. While ATF3-mediated...
Neuropathic Gaucher disease (nGD) is a life-threatening that progresses rapidly and caused by glucosylceramidase beta 1 (GBA1) mutation, which encodes the lysosomal hydrolase β-glucocerebrosidase (GCase). Nerve damage in nGD, associated with stunted growth development, arises from degeneration death of nervous system cells, often irreversible. Approved therapies effectively reduce substrate burden outside central (CNS) through augmenting mutant enzyme activity pharmacologic recombinant GCase...
Two novel tricyclic spirolactones bearing long linear alkyl chains, yaoshanenolides A (1) and B (2), formed by Diels–Alder[4 + 2] cycloaddition of a molecule each butenolide with β-phellandrene, were isolated from the bark Machilus yaoshansis. Their structures absolute configurations determined extensive spectroscopic methods, especially 2D NMR ECD data analysis. The proposed biosynthetic pathway is discussed. Both compounds exhibited nonselective cytotoxic activities against several human...
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 STAT4, rs9275319 HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) a Chinese population, two (rs2596542 MICA, rs9275572 located between HLA-DQA and HLA-DQB) C HCC (HCV-related Japanese population. In the present study, we sought to determine whether these SNPs are predictive for HBV-related development other population well.We genotyped 4 SNPs,...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease, its molecular pathogenesis remains poorly understood. Recently, emerging evidence demonstrates that the PI3K signaling transduction pathway linked to pathology of IPF. In this work, we rationally designed new series 4-methylquinazoline derivatives as highly potent inhibitors significantly suppress phosphorylation main downstream effectors displays marked antiproliferative activity in mouse MLg2908 fibroblasts....
We have examined vitamin D receptor (VDR), thyroid hormone (TR), and retinoid X β (RXRβ) binding to response elements (VDREs), two (TREs) (DR4 F2), a retinoic acid element (DR5). VDR/RXR bound well the VDREs DR4 DR5 using electrophoretic mobility shift assay. Surprisingly, also F2, which contains half-sites arranged as an inverted palindrome. In co-transfection experiments CV-1 cells, we observed that VDR repressed basal transcription in absence of ligand on DR3 osteopontin but had no effect...
Abstract Objective Dyslipidemia correlating to insulin resistance is one of the key features in type 2 diabetes (T2D). Recent studies have demonstrated that apolipoprotein M (apoM) important for formation preβ‐high‐density lipoprotein (HDL) and cholesterol (CHO) efflux macrophages HDL. In present study, we investigated potential association apoM genetic variation with development T2D. Methods Single nucleotide polymorphisms (SNPs) C‐1065A, T‐855C T‐778C proximal promoter region gene were...
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, may not perfectly reflect nature human progression. A comprehensive profiling molecular changes in lungs urgently needed. Here, we conducted RNA sequencing (RNA-seq) on tissues 10 patients and 7 non-diseased donors. total 2,605 differentially expressed genes (DEGs) critical pathway were...
Forsythosides H-J (1-3), three new caffeoyl phenylethanoid glycosides (CPGs), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl., together with six known glycosides: Forsythoside A (4), F (5), E (6), 2-(3,4-dihydroxyphenyl)ethyl-β-D-glucopyranoside (7), phenethyl alcohol β-D-xylo-pyranosyl-(1→6)-β-D-glucopyranoside (8) and calceolarioside B (9). Their structures determined by spectroscopic chemical methods.
Trigeminal neuralgia (TN) is a rare orofacial disorder characterized by severe unilateral paroxysmal pain in the region of fifth cranial nerve. Clinical guidelines recommend carbamazepine (only US Food and Drug Administration-approved drug for TN) oxcarbazepine as first-line therapies. We utilized Truven Health MarketScan database to examine treatment patterns among patients with TN.Included were aged 18 years above, newly diagnosed TN (≥2 diagnoses ≥14 days apart; no diagnosis previous...
Abstract Background Shen-Fu decoction is a traditional Chinese medicine prescription with 3:2 ratio of Radix Ginseng and Fuzi ( Aconiti lateralis praeparata ) . Ginsenosides alkaloids are considered to be the main active components decoction. However, no analytical methods have been used quantitatively analyse both in simultaneously. Results We successfully developed rapid resolution liquid chromatography coupled tandem mass spectrometry (RRLC-MS/MS) method for simultaneous analysis seven...