A5100740311- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Radioactivity and Radon Measurements
- Paraquat toxicity studies and treatments
- Radioactive contamination and transfer
- Heme Oxygenase-1 and Carbon Monoxide
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Advanced Radiotherapy Techniques
- Hepatitis B Virus Studies
- Occupational and environmental lung diseases
- Advanced MRI Techniques and Applications
- Spaceflight effects on biology
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Nutrition and Health in Aging
- Traditional Chinese Medicine Studies
- Inflammatory Bowel Disease
- Stoma care and complications
- Diabetic Foot Ulcer Assessment and Management
- Inflammation biomarkers and pathways
- Ultrasound in Clinical Applications
- Air Quality and Health Impacts
- Graphite, nuclear technology, radiation studies
Fudan University
2023-2025
Nanjing Medical University
2015-2024
Public Health England
2014-2024
Shanghai University
2024
Huashan Hospital
2024
Inform (Germany)
2024
Chongqing Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Nanjing University
2007-2023
Nanjing General Hospital of Nanjing Military Command
2010-2023
This study provides direct evidence of cancer risk from low dose and rate occupational external radiation exposures. Cancer mortality incidence were studied in relation to exposure the National Registry for Radiation Workers. A cohort 167,003 workers followed an average 32 years was analysed using Poisson regression methods. Mortality risks significantly raised group all malignant neoplasms excluding leukaemia (ERR/Sv = 0.28; 90%CI: 0.06, 0.53, ERR/Sv 0.10, 0.48) but with narrower confidence...
Abstract Members of the solute carrier organic anion transporting polypeptide (OATPs) family function as transporters for a large variety amphipathic anions including endogenous metabolites and clinical drugs, such bile salts, steroids, thyroid hormones, statins, antibiotics, antivirals, anticancer drugs. OATP1B1 plays vital role in substances into liver hepatic clearance. FDA EMA recommend conducting vitro testing drug–drug interactions (DDIs) involving OATP1B1. However, structure working...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease, wherein transforming growth factor β (TGF-β) sphingosine-1-phosphate (S1P) contribute to the pathogenesis of fibrosis. However, in vivo contribution sphingosine kinase (SphK) fibrotic processes has not been documented. Microarray analysis blood mononuclear cells from patients with IPF SphK1- or SphK2-knockdown mice SphK inhibitor were used assess role SphKs fibrogenesis. The expression SphK1/2...
Exposure to paraquat results in acute lung injury. A systemic inflammatory response has been widely established as a contributor paraquat-induced Recent studies have reported that consumption of Xuebijing prevents response-induced diseases. This study investigated whether protected rats against Adult male Sprague Dawley were randomly divided into four groups: control group; + and dexamethasone group. Rats the paraquat, groups intraperitoneally injected with (30 mg/kg) or administered at 8...
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease, characterized by damage of epithelial cells, excessive deposition extracellular matrix in the interstitium and enhanced activation proliferation fibroblasts. S100a4, also termed FSP-1 (fibroblast-specific protein-1), was previously considered as marker fibroblasts but recent findings renal liver indicated that M2 macrophages are an important cellular source S100a4. Thus, we hypothesized fibrosis, produce secrete...
To observe the effect of cigarette smoke (CS) on small bowel and colon in mice to attempt explain potential mechanisms that account for these effects.Male BALB/c age 6-8 weeks were randomly divided into a CS group control (n=10 per group). exposed (five cigarettes each time, four times day 5 days week using Hamburg II smoking machine was diluted with air at ratio 1:6) 10 weeks, room air. After sacrificed analysis (colon bowel).CS exposure impaired intestinal barrier bowel, based evidence...
The consideration of risks from medical diagnostic x-ray examinations and their justification commonly relies on estimates effective dose, although the quantity is actually a health-detriment-weighted summation organ/tissue-absorbed doses rather than measure risk. In its 2007 Recommendations, International Commission Radiological Protection (ICRP) defines dose in relation to nominal value stochastic detriment following low-level exposure 5.7 × 10-2Sv-1, as an average over both sexes, all...
BackgroundAbnormalities in mesenteric adipose tissue (MAT) have long been recognized; however, the functional changes adipocytes as well underlying mechanisms are not entirely clear. The aim of this study was to analyze function and morphology MAT patients with Crohn's disease (CD) mechanism.
Purpose To evaluate the accuracy of T 2 ‐based whole‐brain oxygen extraction fraction (OEF) estimation by comparing it with gold standard 15 O‐PET measurements. Methods Sixteen healthy adult subjects underwent MRI and OEF measurements on same day. On MRI, was quantified ‐relaxation‐under‐spin‐tagging (TRUST) based subject‐specific hematocrit. The TRUST compared to averaged produced O‐PET. Agreement between examined in terms intraclass correlation coefficient (ICC) absolute values. In a...
We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality.To identify genes regulated by not other effects of chronic anemia, we compared variation peripheral blood mononuclear cells from 13 subjects SCD hemoglobin SS genotype 15 Chuvash polycythemia (VHL(R200W) homozygotes constitutive upregulation hypoxia-inducible factors absence anemia or hypoxia). At 5% false...
Statistically significant increases in heart disease (HD) mortality with cumulative recorded occupational radiation dose from external sources were observed among 174 541 subjects, who predominately exposed to protracted low doses over a number of years, and followed up until the end 2011 UK National Registry for Radiation Workers (NRRW) cohort. Amongst subtypes HD, increasing trends arose ischaemic (IHD) other HD (which includes pulmonary valve disorders, cardiomyopathy, cardiac...
While the link between risk of leukemia and acute radiation exposure is well established for large doses received acutely, uncertainty remains around translation these estimates to occupational scenarios where are low accumulated over time, possibly many years. We present incidence mortality derived from National Registry Radiation Workers, which a cohort occupationally exposed workers United Kingdom (UK). The comprised 173,081 UK who were monitored radiation. was followed total 5.3 million...
Purpose FLASH radiotherapy (FLASH‐RT) is a novel irradiation modality with ultra‐high dose rates (>40 Gy/s) that have shown tremendous promise for its ability to enhance normal tissue sparing while maintaining comparable tumor cell eradication toconventional (CONV‐RT). Due extremely high rates, clinical translation of FLASH‐RT hampered by risky delivery and current limitations in dosimetric devices, which cannot accurately measure, real time, at deeper tissue. This work aims investigate...
Radiation detriment is a concept to quantify the burden of stochastic effects from exposure human population low-dose and/or low-dose-rate ionising radiation. As part thorough review system radiological protection, International Commission on Radiological Protection (ICRP) has compiled report radiation calculation methodology as Publication 152. It provides historical with details procedure used in ICRP 103. A selected sensitivity analysis was conducted identify parameters and conditions...
There are very few reports available on the role of medical and surgical therapy for enterovesical fistula (EVF) in Crohn's disease (CD). The goal this study was to investigate respective therapy.Thirty-seven patients with EVF CD, who were consecutively admitted our institution between 2004 2011, underwent initial treatment. Medical records abstracted from prospective CD database. We performed a univariate analysis risk factors surgery.The origin ileal (ileovesical fistula, 78.4%) sigmoidal...
When paraquat (PQ) enters the human body, it increases oxidative stress and inflammation, ultimately resulting in acute lung injury (ALI). Curcumin, a naturally occurring compound, has been reported to ameliorate PQ‑induced ALI; however, underlying molecular mechanisms remain unclear. In present study, normal fibroblasts (WI‑38VA13) were treated with 10 µmol/l PQ for 48 h, followed by further h incubation 300 curcumin. Cells then harvested determine their viability. Flow cytometry was...