Mortality and cancer incidence were studied in the National Registry for Radiation Workers in, relative to earlier analyses, an enlarged cohort of 174 541 persons, with longer follow-up (to 2001) and, first time, registration data. SMRs all causes malignant neoplasms 81 84 respectively, demonstrating a ‘healthy worker effect’. Within cohort, mortality from both leukaemia excluding CLL grouping increased statistically significant extent increasing radiation dose. Estimates trend risk dose...

BackgroundThere is much uncertainty about the risks of leukaemia and lymphoma after repeated or protracted low-dose radiation exposure typical occupational, environmental, diagnostic medical settings. We quantified associations between exposures leukaemia, lymphoma, multiple myeloma mortality among radiation-monitored adults employed in France, UK, USA.MethodsWe assembled a cohort 308 297 workers for at least 1 year by Atomic Energy Commission, AREVA Nuclear Cycle, National Electricity...

<b>Study question</b> Is protracted exposure to low doses of ionising radiation associated with an increased risk solid cancer? <b>Methods</b> In this cohort study, 308 297 workers in the nuclear industry from France, United Kingdom, and States detailed monitoring data for external were linked death registries. Excess relative rate per Gy dose mortality cancer was estimated. Follow-up encompassed 8.2 million person years. Of 66 632 known deaths by end follow-up, 17 957 due cancers. answer...

Abstract Objective To evaluate the effect of protracted low dose, dose rate exposure to ionising radiation on risk cancer. Design Multinational cohort study. Setting Cohorts workers in nuclear industry France, UK, and US included a major update International Nuclear Workers Study (INWORKS). Participants 309 932 with individual monitoring data for external total follow-up 10.7 million person years. Main outcome measures Estimates excess relative per gray (Gy) mortality from Results The study...

Incidence of and mortality from cardiovascular diseases have been studied in a cohort 12,210 workers first employed at one the main plants Mayak nuclear facility during 1948-1958 followed up to 31 December 2000. Information on external gamma-ray doses is available for virtually all these (99.9%); mean total dose (+/-SD) was 0.91 +/- 0.95 Gy (99% percentile 3.9 Gy) men 0.65 0.75 2.99 women. In contrast, plutonium body burden measured only 30.0% workers; among those monitored, cumulative liver...

Positive associations between external radiation dose and non-cancer mortality have been found in a number of published studies, primarily populations exposed to high-dose, high-dose-rate ionizing radiation. The goal this study was determine whether associated with large pooled cohort nuclear workers low-dose accumulated at low rates. comprised 308,297 from France, United Kingdom States. average cumulative equivalent tissue depth 10 mm [Hp(10)] 25.2 mSv. In total, 22% the were deceased by...

There is considerable scientific interest in associations between protracted low-dose exposure to ionizing radiation and the occurrence of specific types cancer.

This study provides direct evidence of cancer risk from low dose and rate occupational external radiation exposures. Cancer mortality incidence were studied in relation to exposure the National Registry for Radiation Workers. A cohort 167,003 workers followed an average 32 years was analysed using Poisson regression methods. Mortality risks significantly raised group all malignant neoplasms excluding leukaemia (ERR/Sv = 0.28; 90%CI: 0.06, 0.53, ERR/Sv 0.10, 0.48) but with narrower confidence...

The National Registry for Radiation Workers (NRRW) is the largest epidemiological study of UK radiation workers. Following first analysis published in 1992, a second has been conducted using an enlarged cohort 124 743 workers, updated dosimetry and personal data some longer follow-up. Overall levels mortality were found to be less than those expected from national rates; standardised ratio all causes was 82, increasing 89 after adjusting social class. This `healthy worker effect'...

The weekday and weekend outdoor ultraviolet exposure‐ of young people from primary secondary schools in three geographically distinct regions England was determined over a 3‐month period summer. Ultraviolet exposure measured using personal Him badges worn by each person, time spent outdoors, hourly intervals, assessed records. In area class 9‐10‐year‐old children school 14‐1 5‐year‐old adolescents took part, giving total 180 subjects. We found that received higher than schools, geographical...

Incidence and mortality from cerebrovascular disease (CVD) [International Classification of Diseases 9th revision (ICD-9) codes: 430–438] was studied in a cohort 22,377 workers first employed at the Mayak Production Association (Mayak PA) 1948–1982 followed up to end 2008. The size increased by 19% follow-up extended 3 years over previous analysis. Radiation doses were estimated using an updated dosimetry system: Worker Dosimetry System 2008 (MWDS-2008). For time, analysis this cohort,...

Objective: Incidence and mortality from ischaemic heart disease (IHD) was studied in an extended cohort of 22,377 workers first employed at the Mayak Production Association during 1948–82 followed up to end 2008. Methods: Relative risks excess relative per unit dose (ERR/Gy) were calculated based on maximum likelihood using Epicure software (Hirosoft International Corporation, Seattle, WA). Dose estimates used analyses provided by updated "Mayak Worker Dosimetry System—2008". Results: A...

Abstract The Life Span Study (LSS) of Japanese atomic bomb survivors has served as the primary basis for estimates radiation-related disease risks that inform radiation protection standards. long-term follow-up radiation-monitored nuclear workers provides radiation-cancer associations complement findings from LSS. Here, a comparison mortality risk derived LSS and INWORKS, large international worker study, is presented. Restrictions were made, so two study populations similar with respect to...

The consideration of risks from medical diagnostic x-ray examinations and their justification commonly relies on estimates effective dose, although the quantity is actually a health-detriment-weighted summation organ/tissue-absorbed doses rather than measure risk. In its 2007 Recommendations, International Commission Radiological Protection (ICRP) defines dose in relation to nominal value stochastic detriment following low-level exposure 5.7 × 10-2Sv-1, as an average over both sexes, all...

A cohort of 4,400 persons treated for various cancers childhood in France and the UK was followed up over an extended period to assess risks subsequent brain tumour relation radiotherapy chemotherapy that children received their first cancer. Elevated tumours were associated with central nervous system (CNS) (two-sided p = 0.0002) neurofibromatosis 0.001). There also elevated risk 0.003) ionising radiation exposure, being concentrated among benign unspecified tumours. The radiation-related...

In the framework of International Nuclear Workers Study conducted in France, UK and U.S. (INWORKS), updated expanded methods were developed to convert recorded doses ionizing radiation estimates organ or individual personal dose equivalent [H(p)(10)] for a total number 308,297 workers, including 40,035 women. This approach accounts differences dosimeter response predominant workplace energy geometry exposure recently published ICRP report on coefficients men women separately. The overall...

INWORKS is a multinational cohort study, gathering 308 297 workers in the nuclear industry France, United Kingdom and States of America, with detailed individual monitoring data for external exposure to ionising radiation. Over mean duration follow-up 27 y, number observed deaths was 66 632, including 17 957 due solid cancers, 1791 haematological cancers 848 cardiovascular diseases. Mean cumulative dose over period 1945–2005 25 mSv. Analyses demonstrated significant association between red...

There is some concern that short-term memory loss or other cognitive effects may be associated with the use of mobile cellular telephones. In this experiment, effect repeated, acute exposure to a low intensity 900 MHz radiofrequency (RF) field pulsed at 217 Hz was explored using an appetitively-motivated spatial learning and working task. Adult male C57BL/6J mice were exposed under far conditions in GTEM cell for 45 min each day 10 days average whole-body specific energy absorption rate...

The incidence of and mortality from cerebrovascular diseases (CVD) have been studied in a cohort 12,210 workers first employed at one the main plants Mayak nuclear facility during 1948–1958 followed up to 31 December 2000. Information on external γ-ray doses is available for virtually all these (99.9%); mean total dose (± SD) was 0.91 ± 0.95 Gy (99th percentile 3.9 Gy) men 0.65 0.75 2.99 women. In contrast, plutonium body burden measured only 30.0% workers; among those monitored, cumulative...

Following an earlier study of incidence and mortality ischemic heart disease (IHD) published in 2010, a second analysis has been conducted based on extended cohort five additional years follow-up. The includes 18,763 workers, whom 25% were females, first employed at the Mayak PA 1948-1972 followed up to end 2005. Some these workers exposed external gamma rays only, others mixture gamma-rays internal alpha-particle radiation. A total 6,134 cases 2,629 deaths from IHD identified cohort....

The aim of this study was to estimate cancer mortality and incidence risk associated with external radiation exposure in the BNFL cohort nuclear workers determine if these risks are modified by potential for internal exposure. comprised 64 956 individuals who were employed at four sites between 1946 2002, followed up 2005. External exposures as measured personal dosimeters (generally 'film badges') available 42 431 classified 'radiation workers'. Poisson regression models used investigate...