A5028091840- CRISPR and Genetic Engineering
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Transplantation: Methods and Outcomes
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
- Gallbladder and Bile Duct Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Animal Genetics and Reproduction
- Neonatal Respiratory Health Research
- Virus-based gene therapy research
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cardiovascular Function and Risk Factors
- Renal and related cancers
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Molecular Biology Techniques and Applications
- Blood disorders and treatments
Jilin University
2012-2025
Affiliated Hospital of Hebei University
2025
China Agricultural University
2016-2024
Nanjing Medical University
2015-2024
West China Hospital of Sichuan University
2024
Nanjing General Hospital of Nanjing Military Command
2020-2024
Beijing Anzhen Hospital
2023-2024
Capital Medical University
2020-2024
Qingdao Women and Children's Hospital
2024
Qingdao University
2024
Abstract In recent years, circular RNAs have been shown to serve as essential regulators in several human cancers. Nevertheless, the function and mechanism of CircRNA cervical cancer remain elusive. present study, we showed that hsa_circRNA_101996 was highly expressed tissues compared with matched normal by bioinformatics analysis. We expression level positively correlated TNM stage, tumor size, lymph node metastasis. Moreover, higher levels were related poor outcomes patients. found...
Extracellular superoxide dismutase (EC-SOD) is expressed at high levels in lungs. EC-SOD has a polycationic matrix-binding domain that binds to polyanionic constituents the matrix. Previous studies indicate protects lung both bleomycin- and asbestos-induced models of pulmonary fibrosis. Although mechanism protection not fully understood, these plays an important role regulating inflammatory responses injury. Hyaluronan molecular mass polysaccharide found extracellular matrix sensitive...
Abstract This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured levels 15 individual lncRNAs, known be relevant cardiovascular disease, using whole blood samples collected from 103 AMI patients, 149 non-AMI subjects and 95 healthy volunteers. found that only two them, Zinc finger antisense 1 ( ZFAS1 ) Cdr1 CDR1AS ), showed significant differential expression between patients control subjects....
Abstract Objective Demethylation of CD11a and CD70 regulatory regions in CD4+ T cells contributes to the development autoreactivity overstimulation autoantibodies. Because growth arrest DNA damage–induced 45α (GADD45α) reduces epigenetic silencing genes by removing methylation marks, this study examined whether gadd45A gene could contribute autoimmunity promoting demethylation from patients with systemic lupus erythematosus (SLE). Methods Levels GADD45α, CD11a, messenger RNA (mRNA) protein...
Abstract Pulmonary fibrosis (PF) is a severe pulmonary disease with limited available therapeutic choices. Recent evidence increasingly points to abnormal lipid metabolism as critical factor in PF pathogenesis. Our latest research identifies the dysregulation of low-density lipoprotein (LDL) new risk for PF, contributing alveolar epithelial and endothelial cell damage, fibroblast activation. In this study, we first integrative summarize published literature about metabolite changes found...
Interleukin- (IL-)10 and IL-13 play important roles in Th2 cell differentiation production of autoantibodies patients with (SLE). However, the mechanisms leading to IL10 IL13 overexpression SLE are not well understood. In this study, we confirm that levels both mRNA CD4 + T cells serum proteins increased patients. We show DNA methylation within gene regulatory domains reduced relative healthy controls negatively correlate expression. Moreover, treating demethylating agent 5-azacytidine...
Abstract Although estradiol-17β (E2)-regulated early and late phase uterine responses have been well defined, the molecular mechanisms linking phases remain poorly understood. We previously shown that E2-regulated signals mediate cross talk with estrogen receptor (ER)-α to elicit growth responses. G protein-coupled (GPR30) has implicated in nongenomic signaling mediated by E2, although its role E2-dependent biology is unclear. Using selective activation of GPR30 G-1, we show here a new...
Significance Because genome-wide CRISPR/Cas9 libraries are mostly constructed in lentiviral vectors, direct vivo screening has not been possible as a result of low efficiency delivery. Here, we examined the piggyBac (PB) transposon an alternative vehicle to deliver guide RNA (gRNA) library for screening. Through hydrodynamic tail vein injections, delivered PB-CRISPR into mouse liver. Rapid tumor formation could be observed less than 2 mo. By sequencing analysis PB-mediated gRNA insertions,...
Background. Primary graft dysfunction, which is directly related to cold ischemia–reperfusion (CI/R) injury, a major obstacle in lung transplantation (LTx). Ferroptosis, novel mode of cell death elicited by iron-dependent lipid peroxidation, has been implicated ischemic events. This study aimed investigate the role ferroptosis LTx-CI/R injury and effectiveness liproxstatin-1 (Lip-1), inhibitor, alleviating injury. Methods. LTx-CI/R-induced signal pathway alterations, tissue death,...
Classical dendritic cells (cDCs) are involved in the pathogenesis of inflammatory lung diseases; however, their contributions acute respiratory distress syndrome (ARDS), which is pathophysiologically inflammatory, remain unknown. The present study aimed to explore regulatory effects pulmonary cDCs on inflammation and injury lipopolysaccharide (LPS)‑induced ARDS. Fms‑like tyrosine kinase 3‑ligand (FLT3L) lestaurtinib, a specific activator an inhibitor FLT3 signaling respectively, were used...
Neutrophil extracellular traps (NETs) are web‑like structures made of chromatin and have been identified to a role in the host's immune defense. Differentiated human promyelocytic leukemia HL‑60 cells (dHL‑60) used study mechanisms NETs formation, as neutrophils short lifespan that limits their use. However, dHL‑60 inefficient at generating therefore not ideal replacements for studying NET formation. In present study, optimal cell culture conditions differentiation time result most effective...
Objective: To explore the therapeutic effect of pedicle screw fixation combined with surgical methods in patients severe osteoporosis and compression vertebral fractures (OVCF). Methods: Eighty-two OVCF admitted to our hospital from January 2023 2024 were selected as study subjects. They randomly divided into a control group (n = 41) receiving conventional conservative treatment an observation undergoing vertebroplasty. The effects overall patient satisfaction rates compared between two...