A5100380014- Natural product bioactivities and synthesis
- Receptor Mechanisms and Signaling
- Phytochemistry and Biological Activities
- Mitochondrial Function and Pathology
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Metabolomics and Mass Spectrometry Studies
- Neuropeptides and Animal Physiology
- Phytochemical Studies and Bioactivities
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
Kunming Medical University
2012-2025
Stomatology Hospital
2024-2025
Nanjing University of Chinese Medicine
2024-2025
South China Sea Institute Of Oceanology
2025
Institute of Oceanology
2025
Chinese Academy of Sciences
2025
Chinese University of Hong Kong
2022-2024
Chinese University of Hong Kong, Shenzhen
2022-2024
Shanghai East Hospital
2016-2024
Tongji University
2008-2024
Abstract Inflammatory cytokines, especially tumor necrosis factor α (TNF-α), have been shown to inhibit osteogenic differentiation of mesenchymal stem cells (MSCs) and bone formation in estrogen deficiency–induced osteoporosis, but the mechanism responsible remains poorly understood. MicroRNAs (miRNAs) regulate MSC differentiation. Here, we identified a novel whereby TNF-α, suppressing functional axis key miRNA (miR-21) contributes osteoporosis. In this study, screened differentially...
Aberrant lipid metabolism is a hallmark of colorectal cancer (CRC). Squalene epoxidase (SQLE), rate-limiting enzyme in cholesterol biosynthesis, upregulated CRC. Here, we aim to determine oncogenic function SQLE and its interplay with gut microbiota promoting tumourigenesis.Paired adjacent normal tissues CRC from two cohorts were analysed (n=202). Colon-specific Sqle transgenic (Sqle tg) mice generated by crossing Rosa26-lsl-Sqle Cdx2-Cre mice. Stools collected for metagenomic metabolomic...
Periodontal ligament stem cells (PDLSCs), a new population of mesenchymal (MSCs), have been isolated from the periodontal (PDL). The capacity multipotency and self-renewal makes them an excellent cell source for bone regeneration repair. However, their bone-regeneration ability could be awakened in inflammatory microenvironments, which may result changes differentiation potential. Recently, genetic evidences has shown that Wnt pathway plays important role homeostasis. In this study we...
Mitochondrial diseases are maternally inherited heterogeneous disorders that primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, defects can result in a wide spectrum clinical manifestations. Mitochondria-targeted endonucleases provide an alternative avenue for treating via targeted destruction mtDNA and induction heteroplasmic shifting. Here, we generated disease patient-specific induced pluripotent stem cells...
Exosomes in the tumor microenvironment (TME) facilitate progression by enabling inter-cellular communication. Tumor cell-derived exosomes can polarize tumor-associated macrophages (TAMs) to an immunosuppressive M2 phenotype. The aim of this study was determine role exosomal circFARSA non-small cell lung cancer (NSCLC) and elucidate underlying mechanisms. In situ expression NSCLC tissues analyzed using qRT-PCR. vitro migration cells evaluated a transwell assay or through indirect co-culture...
Abstract Personalized cancer vaccines based on resected tumors from patients is promising to address tumor heterogeneity inhibit recurrence or metastasis. However, it remains challenge elicit immune activation due the weak immunogenicity of autologous antigens. Here, a hybrid membrane vaccine successfully constructed by fusion enhance adaptive response and amplify personalized immunotherapy, which formed codelivery system for antigens adjuvants. Briefly, functional vesicles (HM‐NPs) are...
It has been shown that, during the S-phase of cell cycle, mouse DNA methyltransferase (DNA MTase) is targeted to sites replication by an amino acid sequence (aa 207-455) lying in N-terminal domain enzyme [Leonhardt, H., Page, A. W., Weier, H. U. and Bestor, T. (1992) Cell , 71, 865-873]. In this paper it shown, using enhanced green fluorescent protein (EGFP) fusions, that other peptide sequences MTase are also involved targeting. The work focuses on a sequence, downstream reported targeting...
Rho‑associated protein kinase 1 (ROCK1), a member of the ROCK family, serves an important function in cell migration and invasion neoplasms. ROCK1 has been found to be overexpressed several types cancers. However, role non‑small‑cell lung cancer (NSCLC) is poorly understood. In present study, was NSCLC cells tissues, it associated with poor survival patients. Subsequently, knockdown lines were established using shRNA. significantly reduced ability monolayer scratching Transwell assays. also...
Abstract Dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra midbrain and striatum an important pathologic basis Parkinson’s disease (PD). Recent research has shown that dynamin-related protein 1 (Drp1)-mediated aberrant mitochondrial fission plays a crucial role cell apoptosis. However, upstream regulatory mechanism remains unclear. Our study showed Drp1 knockdown inhibited Importantly, we found ROCK1 was activated MPP + -induced PD model...
Metastasis is the main cause of death in cancer patients. The efficacy pharmacological therapy for limited by heterogeneous nature cells and lack knowledge microenvironments metastasis. Evidence has shown that activated platelets possess both tumor-homing metastasis-targeting properties via intrinsic cell adhesion molecules on platelets, malaria protein VAR2CSA able to specifically bind oncofetal chondroitin sulfate, which overexpressed with epithelial mesenchymal phenotypes. Inspired these...
The inedible bottom part (~30-40%) of asparagus (Asparagus officinalis L.) spears is usually discarded as waste. However, since this by-product has been reported to be rich in many bioactive phytochemicals, it might utilisable a supplement foods or natural drugs for its therapeutic effects. In study was identifed that saponins from old stems (SSA) exerted potential inhibitory activity on tumour growth and metastasis.SSA suppressed cell viability breast, colon pancreatic cancers...
Abstract Proliferation and metastasis are significantly malignant characteristics of human lung cancer, but the underlying molecular mechanisms poorly understood. Chromobox 4 (CBX4), a member Polycomb group (PcG) family epigenetic regulatory factors, enhances cellular proliferation promotes cancer cell migration. However, effect CBX4 in progression is not fully We found that highly expressed tumours compared with adjacent normal tissues. Overexpression migration lines. The knockdown...
Abstract IR ‐783 is a kind of heptamethine cyanine dye that exhibits imaging, cancer targeting and anticancer properties. A previous study reported its imaging properties were related to mitochondria. However, the molecular mechanism behind activity has not been well demonstrated. In this study, we showed inhibits cell viability induces mitochondrial apoptosis in human breast cells. Exposure MDA ‐ MB ‐231 cells resulted loss membrane potential ( MMP ), adenosine triphosphate ATP ) depletion,...
Avian pathogenic Escherichia coli (APEC) causes colibacillosis in avians, resulting considerable losses the poultry industry. APEC showed zoonotic potential initially related to fact that serves as reservoir of virulence genes and antibiotic resistance for other E. coli. Thus, we determine serotypes, phylogenetic groups, distribution, profiles isolates eastern China. A total 230 were isolated from diseased chicken duck with typical symptoms. Serotyping identified O78 (44.78%) was predominant...
Abstract Introduction There is a high morbidity and mortality rate in mechanical trauma (MT)-induced hepatic injury. Currently, the molecular mechanisms underlying liver MT are largely unclear. Exploring developing safe effective medicines to alleviate MT-induced injury an urgent requirement. The aim of this study was reveal role mitochondria-associated ER membranes (MAMs) post-traumatic injury, ascertain whether melatonin protects against by regulating MAMs. Methods Hepatic established...
Periodontitis (PD) is a common chronic inflammatory oral disease that severely affects patients' quality of life. Fisetin has been shown to possess antioxidant and anti-inflammatory properties in various biological systems.