A5045138056- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Cystic Fibrosis Research Advances
- Ginseng Biological Effects and Applications
- Nutritional Studies and Diet
- Frailty in Older Adults
- Gout, Hyperuricemia, Uric Acid
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diabetes Treatment and Management
- Neurological disorders and treatments
- Blood Pressure and Hypertension Studies
- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease Mechanisms and Treatments
- Polysaccharides and Plant Cell Walls
- Cancer, Lipids, and Metabolism
First Affiliated Hospital of Fujian Medical University
2017-2025
Fujian Medical University
2017-2025
Longyan University
2013-2025
Guangzhou University of Chinese Medicine
2025
Kunming Medical University
2016-2024
China Southern Power Grid (China)
2024
National Center for Chronic and Noncommunicable Disease Control and Prevention
2018-2024
Wenzhou City People's Hospital
2024
Northwestern Polytechnical University
2014-2024
Guangdong Provincial People's Hospital
2023-2024
Hydrogen-bonded organic frameworks (HOFs) are crystalline porous polymers which formed by the interaction of hydrogen bonding among building blocks. Unique advantages HOFs, enabling new platforms for exploring multifunctional applications.
A series of crystalline, stable Metal (Metal = Zn, Cu, Ni, Co, Fe, and Mn)-Salen covalent organic framework (COF)
Background: Hypertension is one of the main causes cardiovascular death. Inflammation was considered influential factors (CVD) death in patients with hypertension. Advanced lung cancer inflammation index (ALI) an to assess inflammation, few studies have investigated relationship between advanced and hypertensive patients. Objective: The aim this study investigate association long-term Method: Data from National Health Nutrition Examination Survey (NHANES) 1999–2018 mortality follow-up...
Inflammation plays an important role in the pathophysiology of hypertension (HTN). Aggregate index systemic inflammation (AISI), as a new inflammatory and prognostic marker has emerged recently. Our goal was to determine whether there relationship between HTN AISI. We analyzed patients with from National Health Nutrition Examination Survey (NHANES) 1999 2018. The primary end point cardiovascular mortality. A total 23,765 participants were divided into four groups according AISI quartile...
CFTRΔF508 exhibits a correctable protein-folding defect that leads to its misfolding and premature degradation, which is the cause of cystic fibrosis (CF). Herein we report on characterization biogenic intermediate selected for proteasomal degradation identification cellular components polyubiquitinate CFTRΔF508. Nonubiquitinated accumulates in kinetically trapped, but folding competent conformation, maintained soluble state by cytosolic Hsc70. Ubiquitination Hsc70-bound requires CHIP, U box...
Cystic fibrosis transmembrane conductance regulator (CFTR) is a polytopic membrane protein that functions as Cl(-) channel and consists of two spanning domains (MSDs), cytosolic nucleotide binding (NBDs), regulatory domain. Cytosolic 70-kDa heat shock (Hsp70), endoplasmic reticulum-localized calnexin are chaperones facilitate CFTR biogenesis. Hsp70 in both the cotranslational folding posttranslational degradation CFTR. Yet, mechanism for action quality control not clear. Investigation this...
Abstract Background and aims The relationship between alcohol consumption age‐related diseases is inconsistent. Biological age (BA) serves as both a precursor predictor of diseases; however, longitudinal associations BA in middle‐aged older people remain unclear. We measured whether there was association drinking frequency pure intake with among people. Design setting participants This study involved two prospective cohort studies, set Southwestern China the United Kingdom. A total 8046 from...
Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and sensitivity is uncertain across populations. Early-onset PD (EOPD) represents specific subtype based on clinical features pathogenic mechanisms. It not known if EOPD patients have abnormal echogenicity SN...
Ginsenoside Rg1 (G-Rg1) has various pharmacological properties including antiobesity, immunomodulatory, and anti-inflammatory effects. This study aimed to explore the therapeutic effects underlying mechanisms of G-Rg1 on colitis complicated by obesity. The results indicate that effectively alleviates in obese mice improves serum lipid levels liver function. Importantly, improved composition gut microbiota with colitis, increases alpha diversity indexes Sobs, Ace, Chao, a significant...
BACKGROUND: Obesity is a factor contributing to the occurrence of hypertension and risk for adverse outcomes in populations with hypertension. The changes prevalence obesity remain unclear. Investigating can provide information treatment management METHODS: clinical data from adults aged ≥20 years were extracted National Health Nutrition Examination Survey 2001 2023. primary outcome was (body mass index≥30 kg/m 2 ). trend among American evaluated via test. RESULTS: age-standardized America...
ABSTRACT As the COVID‐19 pandemic continues, increasingly complex vaccination and infection histories have made it urgent to investigate antibody dynamics in populations with hybrid immunity. This study aimed explore multi‐time‐point of SARS‐CoV‐2 IgG levels a community‐based population Jiangsu Province, China, following Omicron BA.5 wave, as well long‐term persistence antibodies nearly 2 years postinfection. A total 2737 participants across Province were followed up at three different time...
The benefits of ideal cardiovascular-health metrics (ICVHMs) in patients with renal insufficiency remain unclear. This study aimed to investigate ICVHM associations prognosis a population. trial enrolled 29,682 participants from the US National Health and Nutrition Examination Survey (NHANES), 2007-2018, mortality follow-up through December 31, 2019. Participants were divided into three groups based on estimated glomerular filtration rates. Cardiovascular health was assessed using new...
Abstract OBJECTIVE To evaluate the effectiveness of denervation sympathectomy (RDN) and pulmonary vein isolation (PVI) for treatment hypertension combined with atrial fibrillation (AF) to examine safety procedure. METHODS Computerized retrieval clinical research papers concerning PVI RDN patients AF from databases Pubmed, Cochrane Library, EMbase, Web Science, Chinese Academic Journals (CNKI), Wanfang documented in period January 2010 April 2023 was conducted. Revman 5.3 software Stata15.1...
Background Inflammation is a key contributor to contrast-induced acute kidney injury (CI-AKI), yet its predictive role remains unclear. The systemic immune-inflammation index (SII) novel inflammatory biomarker, but association with CI-AKI risk in coronary artery disease (CAD) patients undergoing angiography not well established. This study aimed evaluate the relationship between preoperative SII and large multicenter cohort.
Abstract Background Albuminuria has been suggested as an atherosclerotic risk factor among the general population. However, whether this association will be amplified in patients with coronary artery disease (CAD) is unknown. It also unknown diabetes mellitus confounds association. We aim to analyse prognosis of elevated urine albumin creatinine ratio (uACR) CAD population or without type 2 (T2DM). Methods This multi-center registry cohort study included 5,960 CAD. Patients were divided into...
Purpose: This study aimed to evaluate the diagnostic value of different Complete blood count-derived systemic inflammation indexes, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), immune-inflammation index (SII), and neutrophil lymphocyte × platelet (NLPR) in differential diagnosing chronic calculus cholecystitis (CCC) acute (ACC), as well determining severity ACC.Patients Methods: 105 CCC 88 ACC patients were enrolled.NLR, PLR, SII, NLPR evaluated both cohorts...
Hyperuricemia is a risk factor for contrast-induced acute kidney injury in patients with chronic disease. This study evaluated the value of hyperuricemia predicting relatively normal serum creatinine who were undergoing percutaneous coronary interventions.A total 788 baseline (<1.5 mg/dL) intervention prospectively enrolled and divided into hyperuricemic group (n = 211) normouricemic 577). defined as uric acid level>7 mg/ dL males >6 mg/dL females. The incidence was significantly higher than...
The effects of berberine on cardiac function heart failure after myocardial infarction and its possible mechanism were investigated. anterior descending branches 50 female Wistar rats ligatured to establish the model infarction. At 4 weeks successful modeling, randomly divided into two groups receiving 4-week gavage with saline (Sal group) (Ber group), while sham-operation group (Sham was set up. After weeks, hemodynamics serum BNP in measured. hearts taken detect degree fibrosis. cell...