A5045479938- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Gut microbiota and health
- Dialysis and Renal Disease Management
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Antibiotics Pharmacokinetics and Efficacy
- Metabolomics and Mass Spectrometry Studies
- Electrolyte and hormonal disorders
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Hemodynamic Monitoring and Therapy
- Esophageal and GI Pathology
- Nosocomial Infections in ICU
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Garlic and Onion Studies
Southern Medical University
2008-2025
Jinan University
2008-2025
Southern University of Science and Technology
2023-2025
Nanfang Hospital
2015-2025
Guangdong Academy of Medical Sciences
2015-2024
Guangdong Provincial People's Hospital
2008-2024
ShenZhen People’s Hospital
2022-2024
Southwest Jiaotong University
2024
South China University of Technology
2020-2024
Chinese Academy of Sciences
2019-2023
Background and objectives Comprehensive epidemiologic data on AKI are particularly lacking in Asian countries. This study sought to assess the epidemiology clinical correlates of among hospitalized adults China. Design, setting, participants, & measurements was a multicenter retrospective cohort 659,945 from wide range settings nine regional central hospitals across China 2013. defined staged according Kidney Disease Improving Global Outcomes criteria. The incidence estimated using novel...
Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported anti-inflammatory effects on improving the colon system corresponding intestinal microbiota. Herein, a water-soluble garlic polysaccharide (WSGP) was extracted from Jinxiang to evaluate its ameliorating dextran sulfate sodium (DSS)-induced colitis in mouse model. The results showed that (1) after administration WSGP (200 or...
The effects of acute kidney injury (AKI) on liver-related outcomes in patients with hepatitis B virus (HBV) infection remain unclear. study aimed to evaluate the association between AKI mortality and complications HBV infection. multicenter, retrospective cohort included Chinese adults from 24 regional central hospitals January 2000 December 2022. was defined as a ≥ 26.5 μmol/l increase serum creatinine concentration within 48 h, or 50% over baseline 7 days. primary outcome post-discharge...
A major challenge in early treatment of acute cardiorenal syndrome (CRS) is the lack predictors for progression AKI. We aim to investigate utility urinary angiotensinogen and other renal injury biomarkers predicting AKI CRS.In this prospective, multicenter study, we screened 732 adults who admitted decompensated heart failure from September 2011 December 2014, evaluated whether measured at time diagnosis can predict worsening In 213 patients developed Kidney Disease Improving Global Outcomes...
Abstract Mitochondrial dysfunction and impaired Ca 2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level phosphorylation, Orai1 (Ca release-activated calcium channel 1) is important for increase entry into cardiomyocytes. We aimed to explore mechanism Drp1 cardiomyocyte hypertrophy caused high glucose (HG). found that Zucker fat rats induced administration a high-fat diet develop...
Neuroinflammation plays an important part in the pathophysiology of sepsis-associated encephalopathy (SAE). Gut microbiota and gut brain axis are considered as mediators development neurological diseases. The aim this study was to investigate role intestinal sepsis-related injury explore underlying mechanisms.Mouse model SAE established using cecal ligation puncture (CLP). Based on mouse mortality associated time death, light (LSAE) severe (SSAE) were classified. Fecal transplantation (FMT)...
The effects of using gut microbiota metabolites instead live microorganisms to modulate sepsis-induced dysbiosis remain largely unknown. We assessed the metabolite indole-3-propionic acid (IPA) on in mice during sepsis. Sepsis models were constructed by cecal ligation and puncture (CLP) methods. Fecal composition analysis was performed characterize composition. transplantation validate roles sepsis progression. IPA-treated exhibited lower serum inflammatory mediator levels a higher survival...
The bidirectional interactions between the gut microbiota and sepsis-associated encephalopathy (SAE) are not well characterized. We found that was more severely disturbed in SAE-susceptible (SES) mice than SAE-resistant (SER) after sepsis modeling.
Multi-temporal deep learning approaches can make full use of crop growth patterns and phenological characteristics, resulting in excellent classification performance large areas. However, obtaining complete time-series remote sensing images during the growing season is challenging due to cloud contamination. Hence, given multispectral data, it important impute missing data accurately classify crops. A novel Imputation-BiLSTM model (Im-BiLSTM) was developed based on Bidirectional Long...
The role of statin therapy in the development kidney disease patients with type 2 diabetes mellitus (DM) remains uncertain. We aimed to determine relationships between initiation and outcomes DM.
Significance Statement Serum creatinine is not a sensitive biomarker for neonatal AKI because it confounded by maternal level, gestational age, and muscle mass. In this multicenter cohort study of 52,333 hospitalized Chinese neonates, the authors proposed serum cystatin C–related criteria (CyNA) AKI. They found that C (Cys-C) robust identifying in neonates who are at an elevated risk in-hospital mortality CyNA detects 6.5 times as many cases modified Kidney Disease Improving Global Outcomes...
Diabetic nephropathy (DN) is a severe complication of diabetes, characterized by changes in kidney structure and function. The natural product rosmarinic acid (RA) has demonstrated therapeutic effects, including anti-inflammation anti-oxidative-stress, renal damage or dysfunction. In this study, we the heterogeneity cellular response kidneys to DN-induced injury RA treatment at single cell levels. Our results that significantly alleviated tubular epithelial injury, particularly proximal S1...
Abstract Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca 2+ ) has been associated with cardiomyocyte pyroptosis. Specifically, inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is Ca release channel endoplasmic reticulum (ER). However, specific IP3R2 sepsis-induced cardiomyopathy (SIC) not yet determined. Thus, this study aimed to investigate underlying mechanism by which channel-mediated signaling contributes lipopolysaccharide (LPS)—induced...
In this paper, the performance of Al-air batteries based on pure Al, Al–0.1 wt%Ga, wt%In and wt%Sn anodes in 1 M KOH solutions was investigated by galvanostatic discharge test. The electrochemical characteristics were means hydrogen collection, tafel polarization, impedance spectroscopy (EIS), scanning electron microscopy (SEM). results reveal that compared with Al KOH, or exhibits a lower self-corrosion rate higher activity because indium tin high evolution overpotential deposits aluminum...
Hypoxic exposure in the perinatal period causes periventricular white matter damage (PWMD), a condition associated with myelination abnormalities. Under hypoxic conditions, glial cells were activated and released large number of inflammatory mediators PWM neonatal brain, which may result oligodendrocyte (OL) loss axonal injury. This study aims to determine if astrocytes are generate proinflammatory cytokines that be coupled oligodendroglial hypomyelination observed PWMD. Twenty-four...
Neuroinflammation elicited by microglia plays a key role in periventricular white matter (PWM) damage (PWMD) induced infectious exposure. This study aimed to determine if microglia‐derived interleukin‐1β (IL‐1β) would induce hypomyelination through suppression of maturation oligodendrocyte progenitor cells (OPCs) the developing PWM. Sprague‐Dawley rats (1‐day old) were injected with lipopolysaccharide (LPS) (1 mg/kg) intraperitoneally, following which upregulated expression IL‐1β and IL‐1...
We investigated the incidence, perioperative risk factors, and outcomes of postoperative acute kidney injury (AKI) in neurosurgical critically ill patients. A prospective multicenter cohort study was conducted, enrolling adult patients who underwent procedure admitted to intensive care units (ICU). Postoperative AKI diagnosed within 7 days after surgery based on Kidney Disease Improving Global Outcomes criteria. Of 624 enrolled patients, occurred 84 associated with increased rates ICU...
Background and objectives High-quality epidemiologic data on AKI in children are particularly lacking developing countries. This study aimed to assess the epidemiology clinical correlates of among hospitalized China. Design, setting, participants, & measurements We performed a multicenter study, cohort aged 1 month 18 years, from 25 general children’s hospitals China during 2013–2015. obtained patient-level electronic hospitalization information system laboratory databases all who had at...
A major challenge in prevention and early treatment of acute cardiorenal syndrome (CRS) is the lack high-performance predictors. To test hypothesis that urinary angiotensinogen (uAGT) an predictor for CRS 1-year prognosis patients with decompensated heart failure (ADHF), we performed a prospective, two-stage, multicenter cohort study ADHF. In stage I (test set), 317 were recruited from four centers. II (validation 119 enrolled two other Daily uAGT levels analyzed consecutively. AKI was...
Background Current definitions of AKI do not take into account serum creatinine’s high variability in children. Methods We analyzed data from 156,075 hospitalized children with at least two creatinine tests within 30 days. estimated reference change value (RCV) on the basis age and initial level without kidney disease or known risk, we used these to develop a model for detecting pediatric RCV creatinine. defined according optimized (pROCK) as increase beyond creatinine, which was greater 20...
Urinary matrix metalloproteinase-7 (uMMP-7) levels consistently reflect the activity of intrarenal Wnt/β-catenin, which is activated in AKI models. To test hypothesis that uMMP-7 a predictor for severe patients after cardiac surgery, we performed prospective, multicenter, two-stage cohort study 721 undergoing surgery. In stage 1, enrolled 323 children from three academic medical centers. 2, 398 adults at six We analyzed and other injury biomarkers during perioperative period. Severe was...
Dihydroquercetin (DHQ) is a flavonoid compound known for its anti-oxidant effects. Oxidative stress plays dominant role in regulating the pathways associated with systemic inflammatory immune activation during endotoxemia. Whether and how DHQ regulates responses endotoxemia remains elusive. Here we show pretreatment effectively reduced Ten-day mortality bacterial endotoxin lipopolyssacharide (LPS)-challenged mice, suppressing LPS-induced reflected by impaired production of tumor necrosis...