A5103166265- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- Pharmacogenetics and Drug Metabolism
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Organ Donation and Transplantation
- Immunotherapy and Immune Responses
- Transplantation: Methods and Outcomes
- Autophagy in Disease and Therapy
- Colorectal Cancer Treatments and Studies
- Renal Transplantation Outcomes and Treatments
- Kruppel-like factors research
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2016-2025
Wuhan University of Technology
2025
Shenzhen University Health Science Center
2021-2022
Jinan University
2019-2020
Guangdong General Hospital
2014
Guangdong Academy of Medical Sciences
2014
University of Amsterdam
2010
Ferroptosis is an iron-dependent, oxidative cell death, and characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis as a non-apoptotic form death induced small molecules emerging specific cancer types, however, its relevance colorectal (CRC) unexplored remains unclear. Here, we showed that inducer RSL3 initiated ROS HCT116, LoVo HT29 CRC cells over 24 h time...
Failure of immune surveillance related to inadequate host antitumor responses has been suggested as a possible cause the high incidence recurrence and poor overall survival outcome hepatocellular carcinoma. The stress-induced heat shock proteins (HSPs) are known act endogenous "danger signals" that can improve tumor immunogenicity induce natural killer (NK) cell responses. Exosome is novel secretory pathway for HSPs. In our experiments, regulatory effect HSP-bearing exosomes secreted by...
The deregulation of microRNAs (miRNAs) plays an important role in human hepatocarcinogenesis. In this study, we highlight exosomes as mediators involved modulating miRNA profiles hepatocellular carcinoma (HCC) cells. First, examined the different expression HCC cells and cell–derived exosomes. Next, coculture experiments indicated that promoted cell growth, migration, invasion had ability to shuttle miRNAs recipient Further, our data showed Vps4A, a key regulator exosome biogenesis, was...
Abstract Subarachnoid hemorrhage (SAH) is a devastating disease with high mortality. The mechanisms underlying its pathological complications have not been fully identified. Here, we investigate the potential involvement of glymphatic system in neuropathology SAH. We demonstrate that blood components rapidly enter paravascular space following SAH and penetrate into perivascular parenchyma throughout brain, causing disastrous events such as cerebral vasospasm, delayed ischemia,...
Abstract Bio‐inspired helicoidal composite laminates have been found to better impact resistance and energy absorption than conventional laminates. To study the responses damage behaviors of bio‐inspired under high‐velocity impact, with three helix angles were designed tested. Two types light‐gas gun used provide low high energies, velocity was measured using a velocimeter laminate profile observed by scanning electron microscopy. Numerical simulation is then simulate behavior based on...
Oncogenic KRAS plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) development and progression. However, the mechanism has not been clearly elucidated. RKIP is tumor repressor, loss of shown PDAC. Here, we found that expression was inversely correlated with PDAC fresh tissue regardless mutant status. The negative correlation between further confirmed our microarray. overexpression downregulation were associated poor clinical outcomes. Knockdown or cell lines robustly increased...
Dihydroquercetin (DHQ) is a flavonoid compound known for its anti-oxidant effects. Oxidative stress plays dominant role in regulating the pathways associated with systemic inflammatory immune activation during endotoxemia. Whether and how DHQ regulates responses endotoxemia remains elusive. Here we show pretreatment effectively reduced Ten-day mortality bacterial endotoxin lipopolyssacharide (LPS)-challenged mice, suppressing LPS-induced reflected by impaired production of tumor necrosis...
Intrahepatic cholangiocarcinoma (ICC) is a malignant disease characterized by onset occult, rapid progression, high relapse rate, and mortality. However, data on how the tumor microenvironment (TME) regulates ICC metastasis at transcriptomic level remains unclear. This study aimed to explore mechanisms interactions between hepatocytes cells.We analyzed interplay liver through cytokine antibody array analysis. Then we investigated role of N6-methyladenosine (m6A) modification downstream...
Abstract 5-Fluorouracil (5-FU) is known as a first-line chemotherapeutic agent against colorectal cancer (CRC), but drug resistance occurs frequently and significantly limits its clinical success. Our previous study showed that the protocadherin 17 ( PCDH17 ) gene was methylated functioned tumor suppressor in CRC. However, relationship between 5-FU CRC remains unclear. Here, we revealed more highly expressed 5-FU-sensitive tissues than 5-FU-resistant tissues, high expression of correlated...
Abstract Dysregulation of dickkopf-related protein 1 (DKK1) expression has been reported in a variety human cancers. We previously that DKK1 was upregulated hepatocellular carcinoma (HCC). However, the role HCC remains unclear. This study aimed to investigate clinical significance and biological functions HCC. The examined cirrhotic tissues by immunohistochemistry quantitative real-time polymerase chain reaction (qRT-PCR). silenced or overexpressed cell lines, vitro vivo studies were...
Patients with cholangiocarcinoma (CCA) lymph node metastasis (LNM) have the worst prognosis, even after complete resection; however, underlying mechanism remains unclear. Here, we established CAF-derived PDGF-BB as a regulator of LMN in CCA. Proteomics analysis revealed upregulation CAFs derived from patients CCA (LN
In recent years, the deoxycytidine analogue gemcitabine (2',2',-difluorodeoxycytidine) has become first-line chemotherapeutic agent for patients with pancreatic cancer. However, due to intrinsic resistance of cancer cells, gemcitabine-based chemotherapy yields limited disease control, >85% progression at 6 months from diagnosis. Therefore, elucidating mechanisms chemoresistance is a critical step in improving therapy, especially treatment We show PROM2, transmembrane glycoprotein,...
LAG-3 is one of the common tumor immune checkpoints. can inhibit activation and proliferation T cells, also suppress immunity by regulating other immune-related cell functions. FGL1 was recently discovered to be main ligand checkpoint play a critical role in inhibition cells. However, expression circulating cells (CTCs) its clinical significance hepatocellular carcinoma (HCC) remain unclear. Therefore, this bioinformatics analysis performed assess various tumors association with...
Emerging evidence has shown that exosome microRNAs (miRNAs) regulate the development of hepatocellular carcinoma (HCC). Here, influences miR-4800-3p on progression HCC were explored.The expression in derived by transforming growth factor beta 1 (TGF-β1)-treated cells and serum isolated from patients identified real-time PCR. The effects TGF-β1 Huh7-secreted exosomes combined with/without STK25 cell functions explored using EdU assay cloning experiments, wound healing assay, Transwell assay....
Gallbladder carcinoma (GBC) is an extremely aggressive tumor of the biliary tract with a bleak prognosis, and evidence supporting benefit available systemic therapy for advanced GBC scarce. Herein, this study intended to investigate real-world outcome chemotherapy combined programmed death-1 (PD-1) inhibitor management unresectable or recurrent GBC. From January 2018 December 2023, consecutive patients who were treated systematic treatment, including combination plus PD-1 inhibitor,...
Hepatocellular carcinoma (HCC) has high morbidity and mortality. MicroRNAs (miRNAs), which could be regulated by cancer-derived exosomes, play critical regulatory roles in the initiation development of cancer. However, expressions, effects, mechanisms abundant miRNAs HCC exosomes remain largely unclear. Exosomes HepG2 cells under heat shock, TGF-β1, doxorubicin, acid hypoxia/reoxygenation (H/R) conditions, were successfully identified transmission electron microscopy Western blot analysis....
To discuss strategies and prognosis for the emergency treatment of ruptured bleeding in primary hepatocellular carcinoma.The retrospective analysis was performed by examining experiences 60 cases carcinoma. The methods included surgical tumour resection, transcatheter arterial embolization (TAE) non-surgical treatment. Univariate multivariate analyses were to identify risk factors that impacted 30-d mortality research groups.The all patients 28.3% (n = 17). univariate showed Child-Pugh C...
Abstract To evaluate the independent contribution of miRNAs to missing heritability in CYP3A4/5 functionality and atorvastatin metabolism, relationships among three levels factors, namely (1) clinical characteristics, genotypes miRNAs, (2) CYP3A4 CYP3A5 mRNAs (3) CYP3A activity, as well their individual impacts on were assessed 55 human liver tissues. MiR-27b, miR-206 mRNA respectively accounted for 20.0%, 5.8% 9.5% interindividual variations activity. MiR-142 was an contributor expressions...
Osteosarcoma often occurs in children and adolescents with high invasiveness mortality. Polo-like kinase 1 (PLK1) overexpressed most tumors promotes cancer cell proliferation transformation. PLK1 is considered as a therapeutic target for osteosarcoma. RNA interference-based therapies are employed to combat osteosarcoma through silencing gene expression. However, the treatment results remain unsatisfactory due lack of safe efficient nonviral vector. To tackle this hurdle, biodegradable CO2...
Conjugated oligoelectrolyte COE-S6 contains an elongated conjugated core with three cationic charges at each termini of the internal core. As analogue bolaamphiphiles, these structural attributes lead to formation spherical nanoplexes Dh = 205 ± 5.0 nm upon mixing small interfering RNA (siRNA). COE-S6/siRNA nanocomplexes were shown be protective toward RNase, stimulate endosome escape, and achieve transfection efficiencies comparable those achieved commercially available LIP3000. Moreover,...