A5029597787- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial agents and applications
- Virus-based gene therapy research
- Graphene and Nanomaterials Applications
- Microplastics and Plastic Pollution
- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Nanoparticle-Based Drug Delivery
- Conducting polymers and applications
- MicroRNA in disease regulation
- Electromagnetic wave absorption materials
- Wound Healing and Treatments
- Advanced Polymer Synthesis and Characterization
- Polymer Nanocomposites and Properties
- Lower Extremity Biomechanics and Pathologies
- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Advanced Sensor and Energy Harvesting Materials
- Advanced Cellulose Research Studies
- Cancer Research and Treatments
National Sun Yat-sen University
2020-2024
Taoyuan Chang Gung Memorial Hospital
2020-2023
Chang Gung University
2020
National Yunlin University of Science and Technology
2018-2019
Feng Chia University
2015-2018
Chang Gung Memorial Hospital
2001-2017
University at Buffalo, State University of New York
2011-2016
Linkou Chang Gung Memorial Hospital
2012
Virginia Commonwealth University
2012
University of Hawaiʻi at Mānoa
2012
A key end goal of gene delivery research is to develop clinically relevant vectors that can be used combat elusive diseases such as AIDS. Despite promising engineering strategies, efficiency and ultimately modulation efficacy nonviral have been hindered by numerous in vitro vivo barriers resulted subviral performance. In this perspective, we concentrate on the associated with two most common classes vectors, cationic-based lipids polymers. We present existing summarize current...
This study proposes melt-blending polypropylene (PP) and high density polyethylene (HDPE) that have a similar melt flow index (MFI) to form PP/HDPE polyblends. The influence of the content HDPE on properties compatibility polyblends is examined by using tensile test, flexural Izod impact scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential calorimetry (DSC), polarized light (PLM), X-ray diffraction (XRD). SEM results show PP are incompatible...
[Fe(CN)<sub>6</sub>] and [Co(CN)<sub>6</sub>]-based Prussian blue analogues (PBAs) were prepared with various metal ions (<italic>i.e.</italic>, Co, Cu, Fe, Mn Ni) evaluated as catalysts to activate an important oxidant, peroxymonosulfate (PMS).
In this study, we synthesized two conjugated microporous polymers (CMPs), An-Ph-TPA and An-Ph-Py CMPs, using the Suzuki cross-coupling reaction. These CMPs are organic with p-conjugated skeletons persistent micro-porosity contain anthracene (An) moieties linked to triphenylamine (TPA) pyrene (Py) units. We characterized chemical structures, porosities, thermal stabilities, morphologies of newly An-CMPs spectroscopic, microscopic, N2 adsorption/desorption isotherm techniques. Our results from...
A novel approach for the preparation of nanomaterials is developed by tuning miniemulsion reaction systems to be transparent in order enable highly efficient photoreactions. Biodegradable nanoparticles and nanocapsules are obtained UV-induced thiol-ene cross-linking polylactide (PLA)-based precursor polymers preassembled miniemulsions. These well-defined may potentially serve as ideal scaffolds drug delivery. Detailed facts importance specialist readers published "Supporting Information"....
Abstract Well‐defined tertiary amine‐functionalized cationic polylactides (CPLAs) are synthesized by thiol‐ene click functionalization of an allyl‐functionalized polylactide, and utilized for the delivery interleukin‐8 (IL‐8) siRNA via CPLA‐IL‐8 nanoplexes. The CPLAs possess remarkable hydrolytic degradability, their cytotoxicity is relatively low. nanoplexes can be readily taken up prostate cancer cells, resulting in significant IL‐8 gene silencing. It found that degradability CPLAs, as...
In this work, we reported the synthesis of an engineered novel nanocarrier composed biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a was utilized to co-load doxorubicin (DOX) small interfering ribonucleic acid (siRNA), resulting in formation GQD/DOX/BCPV/siRNA nanocomplexes. The nanocomplexes have demonstrated high stability physiologically mimicking media, excellent K-ras downregulation...
Using Sonogashira coupling reactions and a postmodification approach, we successfully synthesized TPET-Im CMP incorporating an imidazolium unit to enhance antibacterial properties optimize its performance as supercapacitor electrode.
Well-defined cationic polylactides (CPLAs) with tertiary amine groups were synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide to yield polymers tunable charge densities. CPLAs have not previously been utilized in the context DNA delivery. Thus, plasmid (pDNA) encoding luciferase was delivered two physiologically distinct cell lines (macrophage and fibroblast) via formation CPLA/pDNA polyplexes electrostatic interaction. The formulated demonstrated high...
Chitosan/poly(vinyl alcohol) (CS/PVA) hybrid nanofibers via electrospinning have been extensively used as wound dressing materials. However, there are still several drawbacks associated with their processing procedures and material properties, including the necessity of using acid solutions spinning solvents, need employing highly toxic cross-linkers, lack stimuli-responsive functions. In this context, water-soluble N-maleoyl functional chitosan (MCS) was successfully synthesized well...
Due to the cell affinity of chitosan (CS) and hydrophilicity polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration. Nonetheless, numerous innate drawbacks NFM system such use toxic spinning solvents cross-linkers, moderate water regain capacity, lack triggered release function significantly hampered their biomedical applications. In order enhance performances in promoting growth preventing...
This study uses the melt compounding method to produce polypropylene (PP)/short glass fibers (SGF) composites. PP serves as matrix while SGF reinforcement. Two coupling agents, maleic anhydride grafted polypropylene, (PP-g-MA) and styrene-ethylene-butylene-styrene block copolymer (SEBS-g-MA) are incorporated in PP/SGF composites during process, order improve interfacial adhesion create diverse desired properties of According mechanical property evaluations, increasing PP-g-MA a agent...
The application of small interfering RNA (siRNA)-based interference (RNAi) for cancer gene therapy has attracted great attention. Gene is a promising strategy treatment because it relatively non-invasive and higher therapeutic specificity than chemotherapy. However, without the use safe efficient carriers, siRNAs cannot effectively penetrate cell membranes RNAi impeded. In this work, cationic poly(lactic acid) (CPLA)-based degradable nanocapsules (NCs) are utilized as novel carriers siRNA...
In this study, polyvinyl alcohol (PVA)/graphene nano‐sheets (GNs) composites are produced via solution mixing and melt compounding methods, where multi‐walled carbon nanotubes (MWCNTs) added during process. After that, the test results show that PVA/GNs composed of 0.25 wt% GNs possess optimal tensile strength, while others 2 have a higher thermal stability, electrical conductivity, electromagnetic interference shielding effectiveness (EMI SE). The addition MWCNTs provides with better...