A5100386280- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Polyamine Metabolism and Applications
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Inflammatory mediators and NSAID effects
- Ferroptosis and cancer prognosis
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- FOXO transcription factor regulation
- Estrogen and related hormone effects
- Adipose Tissue and Metabolism
- Colorectal and Anal Carcinomas
- Single-cell and spatial transcriptomics
- Chemokine receptors and signaling
- Pancreatic and Hepatic Oncology Research
- PARP inhibition in cancer therapy
Dalian Medical University
2022-2025
Chongqing Medical University
2022-2025
Second Affiliated Hospital of Chongqing Medical University
2022-2025
Sun Yat-sen University
2022-2025
Sun Yat-sen University Cancer Center
2022-2025
Wenzhou Medical University
2021-2024
China Medical University
2021-2024
Peking University
2024
Shenzhen University Health Science Center
2020-2023
Bristol-Myers Squibb (United States)
2019-2023
The colonization of bacterial pathogens is a major concern in wound infection and becoming public health issue. Herein, core-shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based nanoplatform was elaborately fabricated to co-load ciprofloxacin (CFL) tumor necrosis factor-α (TNF-α) small interfering RNA (siTNF-α) (AMPC@siTNF-α) for treating the bacterial-infected wound. growth mostly inhibited by released silver ions (Ag+) CFL from AMPC@siTNF-α. Meanwhile, loaded...
Aim: This analysis aimed to evaluate the cost–effectiveness of pembrolizumab monotherapy as first-line treatment in advanced non-small-cell lung cancer patients with a programmed death ligand 1 (PD-L1) tumor proportion score ≥1% from US payer perspective. Materials & methods: A partitioned survival model was developed using efficacy and safety data KEYNOTE-042 trial projected over 20 years. Costs accounted for treatment, toxicity disease management. Quality-adjusted life-years (QALYs)...
Background Cervical cancer is the fourth most and leading cause of cancer-related deaths in women worldwide. Current treatment for patients with advanced cervical limited. And urgent demand novel effective therapies both as first second line these patients, immunotherapy developing fast has made some achievements. Methods This study incorporated 1,255 topic-related articles reviews from 1999 to 2022 Web Science Core Collection (WoSCC). The WoS platform, Citespace, VOS viewer provided annual...
FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia (AML), and associated with poor prognosis a high relapse rate. Gilteritinib, second-generation FLT3 inhibitor, an important target drug for treating patients FLT3-internal tandem duplication (ITD) AML, approved treatment of relapsed/refractory FLT3-mutant leukemia, although challenges such as resistance reduced potency remain. Herein, mitoxantrone-liposomes sensitized FLT3-ITD AML cells to...
Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of the disease for which new therapeutic options are desperately needed. Previously, we showed that high-affinity peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, RS5444, inhibits cell proliferation ATC cells via induction cyclin-dependent kinase inhibitor p21(WAF1/CIP1) (p21). We show here up-regulation RhoB critical step in PPARgamma-mediated activation p21-induced stasis. Using multiple independently...
A total of 13 batches collagen peptide samples were extracted, isolated, and purified from chicken sternal cartilage under various process parameters. The fingerprint profiles peptides established by high-performance liquid chromatography (HPLC). In addition, the amino acid molecular weight distributions investigated. in vitro antioxidant activities measured using 2,2′-Azinobis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH)...
Introduction: Endometrial cancer is one of the most common uterine cancers worldwide. AKT reported to regulate progesterone receptor B dependent transcription and angiogenesis in endometrial cancer. However, potential mechanisms tumor progression remain unclear. Methods: We used GSE72708 with gene expression profiles regulation from GEO database. performed GSEA analysis explore pathway enrichments. found that upregulated enriched pathways siAKT group were associated acid metabolism immune...
Abstract The tumor microenvironment (TME) is of great clinical significance for predicting the therapeutic effect tumors. Nonetheless, there was no systematic analysis cellular interactions in TME head and neck cancer (HNSC). This study used gene expression data from 816 patients with HNSC to analyze scores 22 immune cells. On this basis, we have established a novel TMEscore-based prognostic risk model. relationship between TMEscore genomic characteristics analyzed. sample divided into...
The real-world effect of anti-programmed death ligand 1 (PD-L1) therapies is unclear. We compared US patients who received second-line therapy for non-small-cell lung cancer (NSCLC) before and shortly after Food Drug Administration (FDA) approval PD-L1 inhibitors.Patients in the Flatiron Health database (≥18 years; first-line platinum advanced/metastatic NSCLC; ≥6 months follow-up) were assessed ("historical": January 1, 2011 to December 31, 2013) ("current": 2015 May 2017) FDA anti-PD-L1...
Objective Prognostic indicators in acute coronary syndrome (ACS) would aid decision-making and identifying high-risk patients. The systemic immune-inflammation index (SII) has good prognostic value many diseases; however, its use not been reported for ACS. We aimed to determine the associations between SII outcomes patients with ACS, adjustment confounders. Methods In this retrospective cohort study, we used MIMIC-III (Multiparameter Intelligent Monitoring Intensive Care) database eICU...
Background The therapeutic effect of immune checkpoint inhibitors on tumors is not only related to CD8+ effector T cells but also sufficiently CD4+ helper (T H ) cells. characteristics breast cancer, including gene and tumor-infiltrating lymphocytes, have become significant biomarkers for predicting prognosis immunotherapy response in recent years. Methods Breast cancer samples from Cancer Genome Atlas (TCGA) database triple-negative (TNBC) GSE31519 the Gene Expression Omnibus (GEO) were...
5'-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway and has been reported to suppress tumorigenesis. The MTAP gene located at 9p21, chromosome region often deleted breast cancer (BC). However, clinical biological significance of BC still unclear. Here, we that was frequently downregulated 41% (35/85) primary BCs 89% (8/9) cell lines. Low expression significantly correlated with poor survival patients (P=0.0334). Functional studies showed able both...
Abstract Recent advances suggest that abnormal fatty acid metabolism highly correlates with breast cancer, which provide clues to discover potential biomarkers of cancer. This study aims identify serum free (FFA) metabolic profiles and screen for cancer diagnosis. Gas chromatography–mass spectrometry our in‐house methyl ester standard substances library were combined accurately FFA in samples patients adenosis (as controls). Potential screened by applying statistical analysis. A total 18...
Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here we show that primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung-resident fibroblasts to produce C-C 2/7 (CCL2/7), which, in turn, activate cholesterol synthesis lung-colonizing cells and induce angiogenesis at lung metastatic sites. Inhibiting tumor by pulmonary administration of simvastatin-carrying...
Osteosarcoma often occurs in children and adolescents with high invasiveness mortality. Polo-like kinase 1 (PLK1) overexpressed most tumors promotes cancer cell proliferation transformation. PLK1 is considered as a therapeutic target for osteosarcoma. RNA interference-based therapies are employed to combat osteosarcoma through silencing gene expression. However, the treatment results remain unsatisfactory due lack of safe efficient nonviral vector. To tackle this hurdle, biodegradable CO2...
Abstract Background We aimed to develop a clinical applicable nomogram predict overall survival (OS) for patients with curatively resected nonmetastatic colorectal cancer. Methods Records from retrospective cohort of 846 complete information were used construct the nomogram. The was validated in prospective 379 patients. performance evaluated concordance index (c‐index), time‐dependent receiver operating characteristic (ROC) curves, calibration plots, and decision curve analyses...
The main objective of this study was to evaluate the in vitro antiproliferative effects isoalantolactone against liver cancer cells (Hep-G2) and also monitor its mechanism action. MTT assay involved proliferation assessments phase contrast microscopy used check cellular morphology. Acridine orange/ethidium bromide staining along with western blotting proapoptotic isoalantolactone. DCFH-DA ROS measurements. Transwell migration invasion were executed on Hep-G2 cells. Western expressions...