A5103265280- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Intermetallics and Advanced Alloy Properties
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- Advanced materials and composites
- Cancer-related gene regulation
- Advanced ceramic materials synthesis
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Peptidase Inhibition and Analysis
- Mesoporous Materials and Catalysis
- Oral microbiology and periodontitis research
- Nuclear materials and radiation effects
- RNA Research and Splicing
- Electrodeposition and Electroless Coatings
- Pulmonary Hypertension Research and Treatments
- Medical Imaging Techniques and Applications
- Semiconductor materials and interfaces
- Electrochemical Analysis and Applications
- Dye analysis and toxicity
Fourth Hospital of Hebei Medical University
2017-2025
Hebei Medical University
2017-2025
First Hospital of Shanxi Medical University
2024-2025
Shanxi Medical University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Peking Union Medical College Hospital
2023-2024
Guangdong Provincial People's Hospital
2024
Weatherford College
2022
Central South University
2022
Third Xiangya Hospital
2022
Abstract Background: Mild traumatic brain injury (mTBI) is a common neurological trauma that can lead to cognitive impairment. The sirtuin-1 (SIRT-1)/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) pathway has been reported have neuroprotective effects in rats with craniocerebral injury. We evaluated potential mechanisms underlying electroacupuncture-mediated recovery of function after mTBI, focusing on the SIRT-1/PGC-1α/mitochondrial pathway. Methods: included forty...
This study aimed to investigate the expression levels and clinical implications of interferon α inducible protein 27 (IFI27) N6-methyladenosine (m6A) regulator Alkylation repair homolog 5 (ALKBH5) in head neck squamous cell carcinoma (HNSCC). We employed bioinformatics methods analyze differential IFI27 HNSCC its prognostic implications. Additionally, we explored pathways mechanisms associated with enrichment. Immunohistochemistry (IHC) was used detect adjacent normal tissues. significantly...
To develop a predictive nomogram for breast cancer lympho-vascular invasion (LVI), based on digital tomography (DBT) data obtained from intra- and peri-tumoral regions. One hundred ninety-two patients were enrolled in this retrospective study 2 institutions, which Institution 1 served as the basis training (n = 113) testing 49) sets, while external validation set 30). Tumor regions of interest (ROI) manually-delineated DBT images, ROI was defined mm around intra-tumoral ROI. Radiomics...
BACKGROUND Effective acid suppression significantly enhances the eradication rate of Helicobacter pylori (H. ). AIM To assess efficacy and safety high-dose dual therapy (HDDT) utilizing various highly potent antisecretory medications, thereby providing additional clinical guidance for H. eradication. METHODS The study population comprised untreated patients from three medical centers in central China. From February 10, 2024 to March 31, 2024, 439 subjects were randomly allocated either...
Abstract The tumor microenvironment (TME) is of great clinical significance for predicting the therapeutic effect tumors. Nonetheless, there was no systematic analysis cellular interactions in TME head and neck cancer (HNSC). This study used gene expression data from 816 patients with HNSC to analyze scores 22 immune cells. On this basis, we have established a novel TMEscore-based prognostic risk model. relationship between TMEscore genomic characteristics analyzed. sample divided into...
To reduce the cost of catalyst for direct ethanol fuel cells and improve its catalytic activity, highly ordered Ni-Cu alloy nanowire arrays have been fabricated successfully by differential pulse current electro-deposition into pores a porous anodic alumina membrane (AAMs). The energy dispersion spectrum, scanning transmission electron microscopy were utilized to characterize composition morphology arrays. results reveal that nanowires in array are uniform, well isolated parallel each other....
Periodontitis is a chronic inflammatory disease affecting teeth, periodontal ligament and alveolar bone. Current treatment options include surgery or oral antibiotics. Oral dosage forms shows systemic side effects due to frequent dosing it failed reach the therapeutic concentration in cavity. In this work, novel situ gel loaded with azithromycin laden lipid liquid-crystalline nanoparticles (cubosomes) was formulated for effective of periodontitis. Cubosomes were prepared using DL-α-monoolein...
Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors in head and neck, but its molecular mechanism not clear.Weighted gene co-expression network analysis (WGCNA) combining with differential expression analysis, survival to screen key modules hub genes related progress TSCC. Gene Set Enrichment Analysis (GSEA) was used identify biological pathways that might be involved.Weighted constructed based on dataset GSE34105. The blue module turquoise TSCC were identified...
The present study aimed to determine changes in the concentration of secretory immunoglobulin A (SIgA) and interleukin 6 (IL-6) saliva patients with oral cancer, evaluate abnormal expression cluster differentiation (CD) 1a, CD83, CD80 CD86 on dendritic cells (DCs) cancer tissues discuss interaction between SIgA, IL‑6 DCs cancer. total 40 27 70 years age, median age 52 years, primary were enrolled study, a group 20 healthy male female volunteers was used as control group. SIgA preoperative...
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors head and neck. Programmed death protein 1 (PD-1), programmed ligand (PD-L1) are often overexpressed in OSCC patients, their expression level closely related to tumor prognosis. The objectives this study were: 1) evaluate impact anti-PD-1 treatment on immune system prognosis patients 2) find possible associations between T-cell immunity therapy.A total 120 (divided into two equal groups: "non-anti-PD1 therapy"...
Abstract A malayaite pigment was synthesized with wastewater containing low chromium (Cr)(VI) by a novel liquid-phase reaction method. The effects of the particle size precursor and calcination temperature on final product are examined. result scanning electron microscopy shows that obtained is amorphous approximately 250 nm. results X-ray diffraction differential calorimetry show complete transformation 1050 °C. Furthermore, Commission International de l’Eclairage laboratory red color...
Glutaredoxin proteins (GLXRs) are essential components of the glutathione system that reductively detoxify substances such as arsenic and peroxides important in synthesis DNA via ribonucleotide reductases. NMR solution structures glutaredoxin domains from two Gram-negative opportunistic pathogens, Brucella melitensis Bartonella henselae, presented. These lack N-terminal helix is frequently present eukaryotic GLXRs. The conserved active-site cysteines adopt canonical...
Oral cancer is one of the most common malignant tumors in head and neck. It easy to relapse, prognosis poor. However, molecular mechanism development oral still unclear.A total 30 normal individuals patients with neck who underwent surgery were recruited Fourth Hospital Hebei Medical University between February 2019 November 2021. Furthermore, Human Protein Atlas (HPA) analysis, RT-qPCR, immunofluorescence used verify expression SOX9 IL1A. The GSE69002 dataset was downloaded from Gene...
Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumor types in oral and maxillofacial region. The etiology pathogenesis behind TSCC complicated. In present study, three gene expression profiles, namely GSE31056, GSE13601 GSE78060, were downloaded from Gene Expression Omnibus (GEO). GEO2R online tool was utilized to identify differentially expressed genes (DEGs) between normal tissue samples. Furthermore, a protein‑protein interaction (PPI) network constructed hub...