A5081874439- Helicobacter pylori-related gastroenterology studies
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Urinary and Genital Oncology Studies
- Acute Myocardial Infarction Research
- Bladder and Urothelial Cancer Treatments
- Clostridium difficile and Clostridium perfringens research
- Glycosylation and Glycoproteins Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic and Hepatic Oncology Research
- Cerebrovascular and Carotid Artery Diseases
- Urologic and reproductive health conditions
- Gastroesophageal reflux and treatments
- Prostate Cancer Treatment and Research
- Eosinophilic Esophagitis
- RNA modifications and cancer
- Congenital heart defects research
- Gut microbiota and health
- Peripheral Artery Disease Management
- Iron oxide chemistry and applications
- Cancer Cells and Metastasis
- Lipoproteins and Cardiovascular Health
- Gastrointestinal Bleeding Diagnosis and Treatment
Third Xiangya Hospital
2018-2025
Central South University
2018-2025
Aero Engine Corporation of China (China)
2020
Xiamen University
2019
Dalian Institute of Chemical Physics
2019
Chinese Academy of Sciences
2019
Texas A&M Health Science Center
2008-2013
Creighton University
2010-2013
Central Arkansas Veterans Healthcare System
2011-2013
University of Arkansas for Medical Sciences
2011-2013
Helicobacter pylori infection is mostly a family-based infectious disease. To facilitate its prevention and management, national consensus meeting was held to review current evidence propose strategies for population-wide H. control management reduce the related disease burden.Fifty-seven experts from 41 major universities institutions in 20 provinces/regions of mainland China were invited modify statements using Delphi process grading recommendations assessment, development evaluation...
Background. Urinary bladder sarcomatoid carcinoma (carcinosarcoma) is rare. The objective of this study was to examine the epidemiology, natural history, and prognostic factors urinary carcinosarcoma using population-based registry. Methods. Surveillance, Epidemiology, End Results (SEER) Program database used identify cases by tumor site histology codes. association between clinical demographic characteristics long-term survival examined. Results. A total 221 confirmed were identified 1973...
Carotid artery stenting (CAS) is an alternative to carotid endarterectomy (CEA) for stroke prevention. The value of this therapy relative CEA remains uncertain.In 10 958 Medicare patients aged 66 years or older between 2004 and 2006, we analyzed in-hospital, 1-year stroke, myocardial infarction, death rate outcomes the effects potential confounding variables.CAS (87% were asymptomatic) had a higher baseline risk profile, including having percentage coronary peripheral arterial disease, heart...
Patients with decompensated liver cirrhosis suffering from esophagogastric variceal bleeding (EGVB) face high mortality. To investigate the risk factors for EGVB in patients and establish a diagnostic nomogram. who met inclusion criteria were randomly divided into training validation cohorts 6:4 ratio this retrospective research. Univariate analysis, least absolute shrinkage selection operator regression, multivariate analysis employed to nomogram model. Calibration curve, area under...
Atrophic gastritis (AG) is a chronic inflammation where gastric glandular cells are replaced by intestinal-type epithelium. Gastric epithelial cell loss often linked to multiple death signaling pathways. While Helicobacter pylori (H. pylori) infection the main cause of AG, its role in inducing goes beyond apoptosis and autophagy. Pyroptosis could promote development related cancers, but involvement H. pylori-induced malignant transformation remains unclear. The enrichment pyroptosis across...
BACKGROUND Effective acid suppression significantly enhances the eradication rate of Helicobacter pylori (H. ). AIM To assess efficacy and safety high-dose dual therapy (HDDT) utilizing various highly potent antisecretory medications, thereby providing additional clinical guidance for H. eradication. METHODS The study population comprised untreated patients from three medical centers in central China. From February 10, 2024 to March 31, 2024, 439 subjects were randomly allocated either...
The cardiac outflow tract (OFT) is a developmentally complex structure derived from multiple lineages and often defective in human congenital anomalies. Although emerging evidence shows that fibroblast growth factor(FGF) essential for OFT development, the downstream pathways mediating FGF signaling progenitors remain poorly understood. Here, we report FRS2α (FRS2), an adaptor protein links receptor kinases to pathways, mediates crucial aspects of FGF-dependent development mouse. Ablation...
Background— Experimental studies have demonstrated that intravenous β-blocker administration before coronary artery occlusion significantly reduces myocardial injury. Clinical shown intracoronary (IC) propranolol percutaneous intervention (PCI) delays ischemia. The present study tested the hypothesis IC treatment protects ischemic myocardium from damage and incidence of infarction (MI) short-term adverse outcomes after PCI. Methods Results— Patients undergoing PCI (n=150) were randomly...
Heart valves develop from precursor structures called cardiac cushions, an endothelial-lined jelly that resides in the inner side of heart tube. The cushions are then invaded by cells different sources, undergo a series complicated and poorly understood remodeling processes, give rise to valves. Disruption fibroblast growth factor (FGF) signaling axis impairs morphogenesis outflow tract (OFT). Yet, whether FGF regulates OFT valve formation is unknown.To study how regulated aberrant cell...
Background : This study investigated the frequency of patients with HCC who refused cancer-directed surgery and characteristics outcomes these patients. Patients Methods A retrospective was performed using data from Surveillance, Epidemiology, End Results (SEER) Program. Characteristics CDS were compared those accepted logistic regression. The effect refusing on mortality evaluated by Cox proportional hazards analysis. Among 4373 surgical candidates, 142 (3.2%) recommended CDS. frequently...
Abstract The immobilization of tris(2,2'‐bipyridyl)ruthenium(II) [Ru(bpy) $\rm{ {_{3}^{2+}}}$ ] in a TiO 2 /Nafion nanocomposites membrane modified glassy carbon electrode (GCE) was achieved via both an ion‐exchange process and hydrophobic interactions .The surface‐confined Ru(bpy) shows good electrochemical photochemical activities. underwent reversible surface reacted with chlorphenamine maleate (CPM) to produce electrochemiluminescence. used for the ECL determination CPM. It showed...
The aim of the present study was to examine epidemiology, natural history, treatment and long-term survival patients with adenosquamous cell carcinoma prostate. Surveillance, Epidemiology, End Results (SEER) Program database used identify ASCC prostate cases between January 1973 December 2006. Survival probabilities were estimated using Kaplan-Meier methods compared log-rank test. A total 25 identified during period. median age 74 years (range 53-98). Twenty percent subjects presented...
Optimizing stent deployment is important for both acute- and long-term outcomes. High-pressure balloon inflation the standard coronary implantation. However, there no standardized protocol. We hypothesized that prolonged high-pressure until stabilization of pressure superior to a rapid inflation/deflation sequence expansion strut apposition.A was deployed followed by angiography assure residual stenosis. Optical coherence tomography (OCT) then performed stabilized 30 sec using same at as...
The efficacy and safety of high-dose amoxicillin (AMX) proton pump inhibitors (PPI) dual therapy raises much more attention in recent years. Comparative studies among the therapies are required to explore suitable regimens. This study compared efficacy, adverse events, patient compliance three different regimens treatment-naive patients Helicobacter pylori (H. pylori) infection.The was a prospective, multicenter, open-label, randomized controlled trial, including H. pylori-infected at 12...
O-GlcNAcylation is an important post-translational modification (PTM) jointly controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Aberrant hyper-O-GlcNAcylation reported to yield hepatocellular carcinoma (HCC) malignancy, but the underlying mechanisms of OGT/OGA imbalance responsible for HCC tumorigenesis remain largely unknown. Here, we report that RAN-binding protein 2 (RANBP2), one small ubiquitin-like modifier (SUMO) E3 ligases, contributed malignant phenotypes in HCC. RANBP2...
The aim of this study was to examine the epidemiology, natural history, treatment pattern and predictors long-term survival patients with signet-ring cell carcinoma (SRCC) urinary bladder based on analysis national Surveillance, Epidemiology, End Results (SEER) database.In total, 230 pathologically confirmed SRCC were identified between 1973 2004. mean age 65 ± 13 years. Overall, 75.7% had a poorly differentiated or undifferentiated histology grade, 26.5% presented metastatic disease, 59...
Micropapillary bladder carcinoma (MPBC) is a rare variant of urothelial cancer. Most literature on MPBC from case series reports. This study's objective was to examine the epidemiology, natural history, and prognostic factors using population-based registry, in addition review.The Surveillance, Epidemiology, End Results (SEER) database identified 98 histologically confirmed patients 2001 2007. In addition, 213 cases were published literature. The clinical, demographic characteristics,...