A5073301461- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Inflammatory mediators and NSAID effects
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuropeptides and Animal Physiology
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Pituitary Gland Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2014-2024
Guangdong Medical College
2024
Nanjing Tech University
2024
Shanghai Jiao Tong University
2022-2023
National University of Singapore
2022-2023
Post Graduate Institute of Medical Education and Research
2022-2023
National Center for Global Health and Medicine
2022-2023
National Taiwan University
2022-2023
Helicobacter pylori infection is mostly a family-based infectious disease. To facilitate its prevention and management, national consensus meeting was held to review current evidence propose strategies for population-wide H. control management reduce the related disease burden.Fifty-seven experts from 41 major universities institutions in 20 provinces/regions of mainland China were invited modify statements using Delphi process grading recommendations assessment, development evaluation...
The activation of stimulator interferon genes (STING) and NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis signaling pathways represent two distinct central mechanisms in liver disease. However, the interconnections between these epigenetic regulation STING-NLRP3 axis hepatocyte during fibrosis remain unknown. STING NLRP3 inflammasome are activated fibrotic livers but suppressed by Sting knockout. knockout ameliorated hepatic pyroptosis, inflammation, fibrosis. In vitro,...
Liver cirrhosis is the end stage of chronic liver diseases without approved clinical drugs. In this study, a new strategy that uses C–C chemokine receptor 2 (CCR2) small interfering RNA silencing (siCcr2)-based therapy by loading multivalent siCcr2 with tetrahedron framework DNA nanostructure (tFNA) vehicle (tFNA-siCcr2) was established to attenuate fibrosis. tFNA-siCcr2 successfully synthesized changing physiochemical properties tFNA. Compared naked molecule, complex altered accumulation...
OBJECTIVES: Severe acute pancreatitis (SAP) is still a big challenge. Accumulated data showed that overexpression of cyclooxygenase-2 (COX-2) in and experimental could be attenuated with COX-2 inhibitors. This study was aimed to evaluate whether the occurrence SAP prevented by selective METHODS: A total 190 patients predicted were randomized into convention group or plus inhibitors (C+COX-2-Is) group. Besides conventional treatment all 2 groups, parecoxib (40 mg/d intravenous injection for 3...
Many epidemiological studies have recently been published on acute pancreatitis; however, there is no known report pancreatitis in China. The present study aims to assess the etiology and mortality of severe China.Fifteen medical centers located throughout mainland China were involved this retrospective study. records 1976 patients, who admitted these with diagnosis from December 1990 2005, reviewed. Epidemiological, laboratory, radiological, therapeutic data for each case collected a...
Betaine has previously been demonstrated to protect the liver against alcohol‑induced fat accumulation. However, mechanism through which betaine affects hepatic lipid metabolic disorders not extensively studied. The present study aimed investigate effect of on alcoholic simple fatty and metabolism disorders. A total 36 rats were randomly divided into control, ethanol + groups. Liver function, morphological alterations, content tumor necrosis factor (TNF)‑α levels determined. Hepatic...
Circular RNAs (circRNAs) are crucially involved in cancers as competing endogenous RNA (ceRNA) or microRNA (miRNA) sponges. However, the function and mechanism of circRNAs liver fibrosis remain unknown focus this study. Murine fibrotic models were induced by thioacetamide (TAA) carbon tetrachloride (CCl4 ). Increased angiogenesis is accompanied TAA- CCl4 -induced murine livers. circRNA microarray argonaute 2 (AGO2)-RNA immunoprecipitation (RIP) sequencing (AGO2-RIP sequencing) performed...
To standardize the diagnosis, treatment, and management of esophagogastric variceal bleeding (EVB) in patients with cirrhotic portal hypertension, Chinese Society Hepatology, Gastroenterology, Digestive Endoscopy Medical Association brought together relevant experts, reviewed latest national international progress clinical research on EVB followed evidence-based medicine to update Guidelines Management Cirrhotic Portal Hypertension. The guidelines provide recommendations for hypertension aim...
Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for managing portal hypertension in cirrhotic patients, but the impact of post-TIPS overt hepatic encephalopathy (OHE) on survival remains controversial. While its effect short-term well-documented, long-term implications remain unclear. This study aims to investigate OHE mortality patients variceal bleeding, focusing timing and predictive value beyond first year post-TIPS. A multicenter, retrospective cohort...
The present study was undertaken to clarify the association of clinicopathological features hepatoid adenocarcinoma (HAC) in stomach, a special kind carcinoma that histologically resembled hepatocellular (HCC) and is characterized by large amounts α -fetoprotein (AFP) serum, with clinical prognosis. We collected data follow-up information from total 31 HACs January 2005 December 2012 our hospital. High lymphatic (54.8%) distant (25.8%) metastasis rates before surgery, proportion advanced...
Background Increased intra-hepatic resistance to portal blood flow is the primary factor leading hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) cirrhotic liver might be a potential target ameliorate hypertension. Objective To verify effect celecoxib, selective inhibitor COX-2, on and mechanisms behind it. Methods Cirrhotic model rat was established by peritoneal injection thiacetamide (TAA). 36 rats were randomly assigned control, TAA TAA+celecoxib groups....
The epithelial-mesenchymal transition (EMT) of hepatocytes is a key step for hepatic fibrosis and cirrhosis. Long-term administration celecoxib, selective cyclooxygenase-2 (COX-2) inhibitor, can ameliorate fibrosis. This research aimed to examine the effect celecoxib on EMT during development liver cirrhosis.Cirrhotic model rat was established by peritoneal injection thiacetamide (TAA). Thirty-six rats were randomly assigned control, TAA, TAA + groups. Hepatic expressions tumor necrosis...
The accumulation of extracellular matrix (ECM) proteins in the liver leads to fibrosis and end-stage cirrhosis.C-C motif chemokine receptor 2 (CCR2) is an attractive target for treating fibrosis.However, limited investigations have been conducted explore mechanism by which CCR2 inhibition reduces ECM fibrosis, focus this study.Liver injury were induced carbon tetrachloride (CCl4) wild-type mice Ccr2 knockout (Ccr2 -/-) mice.CCR2 was upregulated murine human fibrotic livers.Pharmacological...
Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to reduced quality of life and shortened expectancy. Population-based estimates the incidence, prevalence, comorbidities CP in China are scarce.To characterize Sichuan Province, China, with population-based data.Data on from 2015 2021 were obtained Health Information Center Province. During study period, total 38090 individuals diagnosed The yearly incidence rate point prevalence (December 31, 2021) calculated. comorbid...
Lymphatic metastasis has always been regarded as a major prognostic indicator for disease progression and guide therapeutic strategies to oral squamous cell carcinoma (OSCC), but date, how tumor cells access spread via the lymphatics have not fully elucidated. Whether metastasize by expansion invasion of pre‐existing peritumoral or induction newly formed within tumors is controversial. In order address this issue find out clinicopathological significance intratumoral lymphangiogenesis, we...
This study was aimed to establish a database of pancreatic fat fractions for healthy men aged 20 70 years using double-echo chemical shift gradient-echo magnetic resonance imaging.The imaging technique used in this study. A phantom fat-water mixtures established test the accuracy sequence. In addition, 126 male volunteers (20-70 years, body mass index ≤ 25) were enrolled. Fat content pancreas (head, body, and tail) examined.On phantom, significant positive linear correlation regression found...
Obesity may aggravate acute pancreatitis (AP) through damaging the intestinal mucosal barrier (IMB). The underlying mechanism remains unclear. This study was aimed to provide further data clarify mechanism. 48 rats were divided into 4 groups: 1) normal control (NC), chow-fed with sham operation, 2) no-obese AP (NAP), taurocholate infusion, 3) obese (OC), high-fat diet (HFD)-fed and 4) (OAP), HFD-fed infusion. Pancreatic pathologic score (11.39 ± 1.76 vs. 14.11 1.05, p = 0.005), permeability...