A5102907838- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Inflammatory mediators and NSAID effects
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Abdominal vascular conditions and treatments
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Parasites and Host Interactions
- Glycosylation and Glycoproteins Research
Sichuan University
2015-2025
West China Hospital of Sichuan University
2015-2025
State Key Laboratory of Biotherapy
2015-2024
Society of Interventional Radiology
2022
National Kaohsiung First University of Science and Technology
2016
National Natural Science Foundation of China
2015
Ministry of Education of the People's Republic of China
2010
Xiamen University
2010
First Affiliated Hospital Zhejiang University
2010
Fujian Medical University
2010
Liver cirrhosis is the end stage of chronic liver diseases without approved clinical drugs. In this study, a new strategy that uses C–C chemokine receptor 2 (CCR2) small interfering RNA silencing (siCcr2)-based therapy by loading multivalent siCcr2 with tetrahedron framework DNA nanostructure (tFNA) vehicle (tFNA-siCcr2) was established to attenuate fibrosis. tFNA-siCcr2 successfully synthesized changing physiochemical properties tFNA. Compared naked molecule, complex altered accumulation...
Purpose To prospectively evaluate the efficacy of a transjugular intrahepatic portosystemic shunt (TIPS) alone and TIPS in association with embolotherapy (TIPS+E) variceal coronary vein to prevent recurrent bleeding stent dysfunction after creation. Materials Methods Institutional review board approval was obtained; all participants provided informed consent. A total 106 patients (66 men, 40 women; age range, 18–70 years) due hepatic cirrhosis were assigned randomly TIPS+E (n = 54) or 52)...
A novel diagnostic immunoassay testing procedure for hepatitis B virus core antibody (anti-HBc) using homogeneous purified full-length antigen (HBcAg) capsids obtained from Escherichia coli was compared with Abbott Architect anti-HBc chemiluminescent microparticle (CMIA; indirect method) against a library of specimens. monoclonal neutralization confirmatory assay then used to determine the degree discordance between The new found be superior in both sensitivity and specificity.
OBJECTIVES: Severe acute pancreatitis (SAP) is still a big challenge. Accumulated data showed that overexpression of cyclooxygenase-2 (COX-2) in and experimental could be attenuated with COX-2 inhibitors. This study was aimed to evaluate whether the occurrence SAP prevented by selective METHODS: A total 190 patients predicted were randomized into convention group or plus inhibitors (C+COX-2-Is) group. Besides conventional treatment all 2 groups, parecoxib (40 mg/d intravenous injection for 3...
Betaine has previously been demonstrated to protect the liver against alcohol‑induced fat accumulation. However, mechanism through which betaine affects hepatic lipid metabolic disorders not extensively studied. The present study aimed investigate effect of on alcoholic simple fatty and metabolism disorders. A total 36 rats were randomly divided into control, ethanol + groups. Liver function, morphological alterations, content tumor necrosis factor (TNF)‑α levels determined. Hepatic...
Circular RNAs (circRNAs) are crucially involved in cancers as competing endogenous RNA (ceRNA) or microRNA (miRNA) sponges. However, the function and mechanism of circRNAs liver fibrosis remain unknown focus this study. Murine fibrotic models were induced by thioacetamide (TAA) carbon tetrachloride (CCl4 ). Increased angiogenesis is accompanied TAA- CCl4 -induced murine livers. circRNA microarray argonaute 2 (AGO2)-RNA immunoprecipitation (RIP) sequencing (AGO2-RIP sequencing) performed...
BACKGROUND Recent advancements in artificial intelligence (AI) have significantly enhanced the capabilities of endoscopic-assisted diagnosis for gastrointestinal diseases. AI has shown great promise clinical practice, particularly diagnostic support, offering real-time insights into complex conditions such as esophageal squamous cell carcinoma. CASE SUMMARY In this study, we introduce a multimodal system that successfully identified and delineated small flat carcinoma during...
Background Increased intra-hepatic resistance to portal blood flow is the primary factor leading hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) cirrhotic liver might be a potential target ameliorate hypertension. Objective To verify effect celecoxib, selective inhibitor COX-2, on and mechanisms behind it. Methods Cirrhotic model rat was established by peritoneal injection thiacetamide (TAA). 36 rats were randomly assigned control, TAA TAA+celecoxib groups....
The epithelial-mesenchymal transition (EMT) of hepatocytes is a key step for hepatic fibrosis and cirrhosis. Long-term administration celecoxib, selective cyclooxygenase-2 (COX-2) inhibitor, can ameliorate fibrosis. This research aimed to examine the effect celecoxib on EMT during development liver cirrhosis.Cirrhotic model rat was established by peritoneal injection thiacetamide (TAA). Thirty-six rats were randomly assigned control, TAA, TAA + groups. Hepatic expressions tumor necrosis...
Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to reduced quality of life and shortened expectancy. Population-based estimates the incidence, prevalence, comorbidities CP in China are scarce.To characterize Sichuan Province, China, with population-based data.Data on from 2015 2021 were obtained Health Information Center Province. During study period, total 38090 individuals diagnosed The yearly incidence rate point prevalence (December 31, 2021) calculated. comorbid...
The accumulation of extracellular matrix (ECM) proteins in the liver leads to fibrosis and end-stage cirrhosis.C-C motif chemokine receptor 2 (CCR2) is an attractive target for treating fibrosis.However, limited investigations have been conducted explore mechanism by which CCR2 inhibition reduces ECM fibrosis, focus this study.Liver injury were induced carbon tetrachloride (CCl4) wild-type mice Ccr2 knockout (Ccr2 -/-) mice.CCR2 was upregulated murine human fibrotic livers.Pharmacological...
Numerous observational studies suggest associations between proton pump inhibitors (PPIs) and dementia, but causal relationships remain uncertain. Using large-scale genome-wide association study (GWAS) data, we performed univariable Mendelian randomization (UVMR) analysis to assess the causality five PPI types, all-cause dementia its subtypes. Confounders were controlled through multivariable MR (MVMR) isolate PPIs' direct effects on dementia. Heterogeneity pleiotropy assessments,...
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. MASLD and its advanced-stage fibrosis cirrhosis are leading causes failure liver-related death worldwide. Mitochondria crucial organelles in cells for energy generation oxidative metabolism fatty acids carbohydrates. Recently, mitochondrial dysfunction has been shown to play a vital role pathogenesis fibrosis. Mitophagy, selective form autophagy, removes recycles...
This study was designed to control plant fertility by cell lethal gene Barnase expressing at specific developmental stage and in tissue of male organ under the Cre/loxP system, for heterosis breeding, producing hybrid seed eggplant. The Barnase-coding region flanked loxP recognition sites Cre-recombinase. eggplant inbred/pure line ('E-38') transformed with Cre ('E-8') situated between loxp. experiments were done separately, means Agrobacterium co-culture. Four T0-plants obtained, all proved...
To evaluate the efficacy of octreotide in preventing severe acute pancreatitis (SAP) obese patients.A prospective multi-center partly randomized control trial was conducted patients with mild (AP). Nonobese received conventional management (nonobese-C, n = 82), whereas (body mass index ≥ 25 kg/m(2)) were into 2 groups: obese-C (n 79), who management, and obese-C+O plus intravenous infusion octreotide, 50 μg/h for 72 hours.The risk ratio relative reduction development SAP group 0.27 (95%...
Abstract AZD6244 (ARRY-142886), a highly selective MAPK-ERK kinase inhibitor, has shown excellent clinical efficacy in many tumors. However, the anti-tumor and anti-angiogenesis of on gastric cancer not been well characterized. In this study, high p-ERK expression was associated with advanced TNM stage, increased lymphovascular invasion poor survival. For absence NRAS, KRAS BRAF mutation, SGC7901 BGC823 cells were relative resistance to vitro . And such attributed insufficient inhibition ERK...
// Huan Tong 1 , Bo Wei Shuang Chen Yong-Mei Xie 2 Ming-Guang Zhang Lin-Hao Zhi-Yin Huang and Cheng-Wei Tang Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Pediatrics, Second University Correspondence to: Tang, email: Keywords : hepatocellular carcinoma, transarterial chemoembolisation, celecoxib, lanreotide, survival Received October 07, 2016 Accepted February 15, 2017 Published 24, Abstract Recurrence carcinoma (HCC) after chemoembolisation (TACE) is...