A5100376542- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Gallbladder and Bile Duct Disorders
- Ion Transport and Channel Regulation
- Inflammatory mediators and NSAID effects
- Pancreatic function and diabetes
- Barrier Structure and Function Studies
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- EEG and Brain-Computer Interfaces
- Tryptophan and brain disorders
- Lipid metabolism and disorders
- Bone health and treatments
- PI3K/AKT/mTOR signaling in cancer
- Digestive system and related health
- Estrogen and related hormone effects
- Electrolyte and hormonal disorders
- Gaze Tracking and Assistive Technology
- Cancer, Stress, Anesthesia, and Immune Response
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Shandong Tumor Hospital
2025
Shandong First Medical University
2025
Columbia University
2024-2025
Center for Innovation
2023-2025
Yantaishan Hospital
2025
New York Hospital Queens
2023-2025
NewYork–Presbyterian Hospital
2023-2025
Tongji University
2025
The present study aimed to investigate changes in cellular immune function and regulatory T cells (Tregs) patients with hepatocellular carcinoma (HCC) prior following transcatheter arterial chemoembolization (TACE) their clinical significance. proportion of CD4+ CD8+ Tregs the peripheral blood between healthy volunteers HCC were detected by flow cytometry (1 day) one month TACE. level interleukin (IL)‑35 was examined ELISA. In HCC, total lymphocytes significantly lower compared that...
Electroencephalography (EEG) is a non-linear and non-stationary process, as result, its features are unstable often vary in quality across trials, which poses significant challenges to brain-computer interfaces (BCIs). One remedy this problem adaptively collect sufficient EEG evidence using dynamic stopping (DS) strategies. The high-speed steady-state visual evoked potential (SSVEP)-based BCI has experienced tremendous progress recent years. This study aims further improve the SSVEP-based by...
Objective: To report our endoscopic outcomes and explore the effects of duration impaction anesthetic methods on removal foreign bodies in upper gastrointestinal tract.Methods: All consecutive patients with suspected body (FB) ingestion between January 2013 June 2016 were enrolled. Demographic, clinical data collected analyzed.Results: A total 1294 aged seven months to 94 years Odynophagia (415 cases, 32.1%), FB sensation (340 26.3%) sore throat (267 20.1%) most frequent complaints. The...
Common spatial pattern (CSP) method is widely used for filtering and brain extraction from electroencephalogram (EEG) signals in motor imagery (MI)-based brain-computer interfaces (BCIs). The participant-specific time window relative to the visual cue has a significant impact on effectiveness of CSP. However, usually selected experientially or manually. To solve this problem, we propose novel feature selection approach MI-based BCIs. Specifically, multiple segments were obtained by...
Degradation of mRNA by RNA interference is one the most powerful and specific mechanisms for gene silencing. However, insufficient cellular uptake poor stability have limited its usefulness. Here, we report efficient delivery siRNA via use biodegradable nanoparticles (NPs) made from monomethoxypoly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly-l-lysine (mPEG-PLGA-PLL) triblock copolymers. Various physicochemical properties mPEG-PLGA-PLL NPs, including morphology, size, surface charge,...
Abstract Postoperative pain (POP) can promote tumor recurrence and reduce the cancer patient's quality of life. However, POP management has always been separated from treatment in clinical practice, traditional postoperative analgesia using opioids is still unsatisfactory for patients, which not conducive to treatment. Here, ropivacaine, a popular amide-type LA, was introduced into Pluronic F127 hydrogel. with ropivacaine-loaded hydrogels reduced incidence high-dose ropivacaine-induced...
Sodium/hydrogen exchanger 8 (NHE8), the newest member of SLC9 family, is expressed at apical membrane epithelial cells in intestine and kidney. Although NHE8 has been shown to be an important player for intestinal sodium absorption early development, its physiological role remains unclear. Here, we successfully created a knockout (NHE8(-/-)) mouse model study function this transporter tract. Embryonic stem containing interrupted gene were injected into blastocyst produce NHE8(+/-) chimeras....
The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this metastasis, transient receptor potential polycystic 2 (TRPP2) enhances metastasis by regulating EMT human laryngeal squamous cell carcinoma. present study examined whether exosomes/TRPP2 small interfering RNA (siRNA) complexes were able reduce suppressing TRPP2 expression FaDu cells, a line of...
The low density lipoprotein receptor （LDLR) gene (OMIM#606945)encodes a protein of 860 amino acids. encoded typically anchors itself to the cell membrane, where it facilitates binding and internalization low-density lipoprotein/cholesterol into cell. Once inside, lysosomes liberate cholesterol, which then becomes available suppress activity microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This serves as rate-limiting step in biosynthesis cholesterol. We generated...
ABSTRACT Background Contrast volume is a major risk factor for acute kidney injury (AKI) in patients with chronic disease (CKD) after TAVR. Use of low‐contrast (LC) protocol TAVR may reduce AKI without impacting other clinical outcomes. Methods Stage 3b or worse CKD between 2015 and 2020 were grouped into LC normal‐contrast (NC). was defined as procedure contrast use (mL) less than estimated glomerular filtration rate (eGFR, mL/min/1.73 m 2 ). The primary outcome AKI, creatinine elevation...
Photodynamic therapy (PDT) has emerged as an ideal candidate among reactive oxygen species (ROS)-mediated tumor therapies. However, the self-repair of DNA, a hallmark mechanism induced by excessive intracellular ROS is one leading causes PDT resistance. To overcome this challenge, we construct therapeutic system, Ce6@MSN-ZOP-HA, wrapped with hyaluronic acid (HA) for binding to highly expressed CD44 on triple negative breast cancer (TNBC) and loaded DNA damage repair inhibitor (olaparib) p38...
This study develops a predictive model to evaluate mortality risk in severe fever with thrombocytopenia syndrome (SFTS) patients intensive care units (ICU) improve the accuracy of prognosis and guide optimization treatment strategies. In this study, retrospective analysis was conducted on SFTS admitted ICU between July 2019 October 2023. Patients were categorized into survival groups. Multivariate logistic regression performed determine independent factors (IRFs) for mortality. addition,...
Preeclampsia (PE) is a heterogeneous syndrome affecting 2% to 8% of all pregnancies and the world's leading cause fetal maternal morbidity mortality. In many cases PE, shallow trophoblast invasion results in inappropriate spiral artery remodeling impaired placental function. Multiple genes have been implicated invasion, among which are KiSS-1 GPR54. The gene product metastin, ligand for receptor Both metastin GPR54 expressed placenta normal pregnancy modulating through inhibiting migration...
Abstract Vascular endothelial growth factor ( VEGF ) is a secreted mitogen associated with angiogenesis. has long been thought to be potent neurotrophic for the survival of spinal cord neurons. However, role in regulation ischemic brain injury remains unclear. In this study, rats were subjected MCAO (middle cerebral artery occlusion) followed by intraperitoneal injection 165 (10 mg/kg) immediately after surgery and once daily until day 10. The expression target genes was assayed using qPCR ,...
Previous studies reported that administration of somatostatin (SST) to human patients mitigated their diarrheal symptoms. Octreotide (an analog SST) treatment in animals resulted upregulation sodium/hydrogen exchanger 8 (NHE8). NHE8 is important for water/sodium absorption the intestine, and loss function results mucosal injury. Thus we hypothesized expression inhibited during colitis SST pathological conditions can restore expression. Our data showed first time expressed colonic tissue...
Background: Liver cirrhosis is a major global health burden worldwide due to its high risk of morbidity and mortality. Role terlipressin for the management liver cirrhosis–related complications has been recognized during recent years. This article aims develop evidence-based clinical practice guidance on use complications. Methods: Hepatobiliary Study Group Chinese Society Gastroenterology Medical Association Hepatology Committee Research Hospital have invited gastroenterologists,...
Patulin (PAT), a mycotoxin mainly produced by Penicillium and Aspergillus, is frequently detected in moldy fruits fruit products. Exposure of human embryonic kidney (HEK293) cells to PAT led dose- time-dependent increase the phosphorylation two major mitogen-activated protein kinases (MAPKs), p38 kinase c-Jun N-terminal (JNK). The phosphorylated forms MAPK 4 (MKK4), c-Jun, ATF-2 were also seen PAT-treated cultures. cell death caused was significantly reduced inhibitor, SB203580, but not JNK...
Objective: The effect of early endoscopic intervention (EI; within 72 hours) remains a controversial subject. This prospective study was aimed to evaluate the efficacy EI without fluoroscopy on severe acute biliary pancreatitis (SABP) in intensive care unit (ICU). Methods: Fifty-three patients with SABP + ampullary obstruction ICU were divided randomly into 2 groups: conservative treatment (CTI arm) and CTI aid arm). Decreased Acute Physiology Chronic Health Evaluation II score major...
Sodium/hydrogen exchanger (NHE) 8 is an apically expressed membrane protein in the intestinal epithelial cells. It plays important roles sodium absorption and bicarbonate secretion intestine. Although NHE8 mRNA has been detected stomach, precise location physiological role of gastric glands remain unclear. In current study, we successfully expression glandular region stomach by Western blotting located at apical surface mucous cells a confocal microscopic method. We also identified...