A5024025794- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Metal complexes synthesis and properties
- Cancer-related gene regulation
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Axon Guidance and Neuronal Signaling
- Cancer Research and Treatments
- Nanocluster Synthesis and Applications
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- X-ray Diffraction in Crystallography
- Mobile Ad Hoc Networks
- Alzheimer's disease research and treatments
- Ferrocene Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- Cancer Immunotherapy and Biomarkers
Tongji University
2016-2025
First Affiliated Hospital of GuangXi Medical University
2020-2025
Harbin University of Science and Technology
2024-2025
Nankai University
2010-2025
Shanghai East Hospital
2018-2025
Affiliated Hospital of Jining Medical University
2014-2025
Guangxi Medical University
2020-2025
Shanghai Tenth People's Hospital
2023-2025
State Grid Corporation of China (China)
2023-2024
Northwest A&F University
2021-2024
Cancer immunotherapy has achieved promising clinical responses in recent years owing to the potential of controlling metastatic disease. However, there is a limited research prove superior therapeutic efficacy on breast cancer compared with melanoma and non-small-cell lung because its expression PD-L1, low infiltration cytotoxic T lymphocytes (CTLs), high level myeloid-derived suppressor cells (MDSCs). Herein, multifunctional nanoplatform (FA-CuS/DTX@PEI-PpIX-CpG nanocomposites, denoted as...
The first stage of 3T3-L1 adipocyte differentiation is growth arrest, which achieved by contact inhibition at confluence. In growth-arrested confluent preadipocytes, alpha-tubulin acetylation and primary-cilium formation were induced. blockade suppressing IFT88 or Kif3a inhibited differentiation. IGF-1 (IGF-I)-receptor signaling, essential for induction, was sensitized the a primary cilium in preadipocytes. receptor located more sensitive to insulin stimulation than that not cilia. During...
Upconversion (UC) luminescent lanthanide nanoparticles (LNPs) are expected to play an important role in imaging and photodynamic therapy (PDT) vitro vivo. However, with the absorption of UC emissions by photosensitizers (PSs) generate singlet oxygen ((1)O2) for PDT, signals from LNPs significantly weakened. It is activate another route track location during PDT process. In this work, Nd(3+)-sensitized dual-band visible near-infrared (NIR) under single 808 nm excitation were reported address...
Abstract Glucose oxidase (GOx), which catalyzes the conversion of glucose into gluconic acid and hydrogen peroxide (H 2 O ) in presence oxygen (O ), has aroused growing interest for cancer therapy. GOx can starve tumor cells to death by depleting glucose, is very important their energy supply, generated H be used oxidation In addition, GOx‐catalyzed exerts a variety effects on environment, such as enhancing hypoxia increasing acidity. The full use these characteristics effectively reduce...
Abstract Given that traditional anticancer therapies fail to significantly improve the prognoses of triple negative breast cancer (TNBC), new modalities with high efficiency are urgently needed. Herein, by mixing metal‐phenolic network formed tannic acid (TA), bleomycin (BLM), and Fe 3+ glutathione peroxidase 4 (GPX4) inhibitor (ML210) loaded hollow mesoporous Prussian blue (HMPB) nanocubes, HMPB/ML210@TA‐BLM‐Fe (HMTBF) nanocomplex is prepared favor ferroptosis/apoptosis synergism in TNBC....
Constitutive activation of signal transducer and activator transcription 3 (STAT3) is a common feature in human non-small cell lung cancer (NSCLC).STAT3 plays an important role progression as driver oncogene acquired resistance targeted therapies alternatively activated pathway.W2014-S with pharmacophore structure imidazopyridine, which was firstly reported to be utilized STAT3 inhibitor discovery, screened out potent from library small molecules.The aim this study investigate the antitumor...
Abstract Electrolytes with anion‐dominated solvation are promising candidates to achieve dendrite‐free and high‐voltage potassium metal batteries. However, it's challenging form anion‐reinforced solvates at low salt concentrations. Herein, we construct an structure a moderate concentration of 1.5 M weakly coordinated cosolvent ethylene glycol dibutyl ether. The unique accelerates the desolvation K + , strengthens oxidative stability 4.94 V facilitates formation inorganic‐rich stable...
Antibiotic resistance has become a critical health crisis globally. Traditional strategies using antibiotics can lead to drug-resistance, while inorganic antimicrobial agents cause severe systemic toxicity. Here, we have developed dual-antibiotic hydrogel delivery system (PDA-Ag@Levo/CMCS), which achieve controlled release of clinical levofloxacin (Levo) and classic nanoscale antibiotic silver nanoparticles (AgNPs), effectively eliminating drug-resistant P. aeruginosa. Benefiting from the...
Abstract Eph receptors, the largest subfamily of transmembrane tyrosine kinase have been increasingly implicated in various physiologic and pathologic processes, roles family members during tumorigenesis recently attracted growing attention. Until now, research on EphB3 function cancer is limited to focusing tumor suppression by EphB receptors colorectal cancer. However, its other types remains poorly investigated. In this study, we explored non–small-cell lung (NSCLC). We found that...
We investigated the oncogenic role of SETDB1, focusing on non-small cell lung cancer (NSCLC), which has high expression this protein. A total 387 cases were examined by immunohistochemistry; 72% NSCLC samples positive for SETDB1 staining, compared to 46% normal bronchial epithelium (106 cases) (p <0.0001). The percentage cells and intensity staining increased significantly with grade disease. Forced in lines enhanced their clonogenic growth vitro markedly tumour size a murine xenograft...