A5050051156- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Renal Transplantation Outcomes and Treatments
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Estrogen and related hormone effects
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Prostate Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Head and Neck Cancer Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Sclerosis and Related Diseases
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Fibroblast Growth Factor Research
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
Guy's and St Thomas' NHS Foundation Trust
2025
University of California, Los Angeles
2015-2024
Indraprastha Institute of Information Technology Delhi
2023
Indian Institute of Technology Delhi
2023
UCLA Jonsson Comprehensive Cancer Center
2003-2015
Olive View-UCLA Medical Center
2015
Los Angeles City College
2015
Revlon (United States)
2013
Kyung Hee University
2013
University of Colorado Cancer Center
2005-2012
The effect of screening with prostate-specific–antigen (PSA) testing and digital rectal examination on the rate death from prostate cancer is unknown. This first report Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial prostate-cancer mortality.
Hypercholesterolemia is common after cardiac transplantation and may contribute to the development of coronary vasculopathy. Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been shown be effective safe in lowering cholesterol levels transplantation. Cell-culture studies using inhibitors HMG-CoA have suggested an immunosuppressive effect.
Specimen collection is an integral component of clinical research. Specimens from subjects with various stages cancers or other conditions, as well those without disease, are critical tools in the hunt for biomarkers, predictors, tests that will detect serious diseases earlier more readily than currently possible. Analytic methodologies evolve quickly. Access to high-quality specimens, collected and handled standardized ways minimize potential bias confounding factors, key "bench bedside"...
<h3>Objective</h3> The associations between oral diseases and increased risk of pancreatic cancer have been reported in several prospective cohort studies. In this study, we measured variations salivary microbiota evaluated their potential with chronic pancreatitis. <h3>Methods</h3> This study was divided into three phases: (1) microbial profiling using the Human Oral Microbe Identification Microarray to investigate variation 10 resectable patients matched healthy controls, (2)...
New biomarkers are needed to detect pleural mesothelioma at an earlier stage and individualize treatment strategies. We investigated whether fibulin-3 in plasma effusions could meet sensitivity specificity criteria for a robust biomarker.
A sensitive assay to identify biomarkers using non-invasively collected clinical specimens is ideal for breast cancer detection. While there are other studies showing disease in saliva cancer, our study tests the hypothesis that discriminatory de novo discovery and validation approaches. This first of this kind no has engaged a biomarker approach In study, case-control independent preclinical validations were conducted evaluate performance translational utilities salivary transcriptomic...
Recent studies have demonstrated that discriminatory salivary biomarkers can be readily detected upon the development of systemic diseases such as pancreatic cancer, breast lung and ovarian cancer. However, utility for detection has been undermined due to absence biological mechanistic rationale why distal from oral cavity would lead in saliva. Here, we examine hypothesis tumor-derived exosomes are mechanistically involved cancer-discriminatory transcriptomic biomarkers. We first developed a...
Monocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth through disruption of lactate transport and glycolysis. Here, we show MCT1 impairs proliferation glycolytic breast cancer cells co-expressing MCT4 via pyruvate rather than export. expression elevated in tumors, high predicts poor prognosis lung patients. Acute reduces export but does not consistently alter or flux that co-express MCT4. Despite the lack glycolysis impairment, loss-of-function decreases cell...
Background: The benefit of screening for prostate cancer using prostate-specific antigen (PSA) testing and digital rectal examination (DRE) is uncertain under evaluation in a randomized prospective trial, the Prostate, Lung, Colorectal Ovarian (PLCO) Cancer Screening Trial. Although final results are several years away, initial round complete. We describe population enrolled PLCO their baseline PSA DRE results, diagnostic follow-up during first year follow-up. Methods: A total 38 350 men...
Hyperlipidemia is an important complication of kidney transplantation affecting up to 74% recipients. HMG-CoA reductase inhibitors are reported provide safe and effective treatment for this problem. A recent study suggests that pravastatin, inhibitor, also decreases the incidence both clinically severe acute rejection episodes natural killer cell cytotoxicity after orthotopic heart transplantation. We have performed a prospective randomized pilot effect pravastatin on these same parameters...
Abstract Background: Oral cancer is the sixth most common with a 5-year survival rate of approximately 60%. Presently, there are no scientifically credible early detection techniques beyond conventional clinical oral examination. The goal this study to validate whether seven mRNAs and three proteins previously reported as biomarkers capable discriminating patients squamous cell carcinomas (OSCC) from healthy subjects in independent cohorts by National Cancer Institute (NCI)-Early Detection...
Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly non-small cell lung carcinoma (NSCLC). Mutations identified EGFR predict sensitivity to EGFR-targeted therapy. Detection these mutations mainly based on tissue biopsy, which invasive, expensive, and time consuming.Noninvasive, real-time, inexpensive detection monitoring patients with NSCLC highly desirable.We developed a novel core technology, electric field-induced release...
OBJECTIVE To describe the results of first four rounds (T0‐T3) prostate cancer screening in Prostate, Lung, Colorectal and Ovarian (PLCO) trial (designed to determine value cancers), that for is evaluating whether annual with prostate‐specific antigen (PSA) a digital rectal examination (DRE) reduces cancer‐specific mortality. SUBJECTS AND METHODS In all, 38 349 men aged 55–74 years were randomized undergo PSA (abnormal >4.0 ng/mL) DRE. The follow‐up abnormal was at discretion subjects’...
For clinical applications of biomarkers, there is a need for multiplex assays using high throughput platforms. The objective this study was to determine the efficacy Luminex Multianalyte Profiling (xMAP) technology measurement salivary proteins and evaluate whether are as effective single-plex enzyme-linked immunosorbent assay (ELISA).The average levels interleukin-8 (IL-8) from were 3313.2 +/- 3759.8 pg ml(-1) [oral squamous cell carcinoma (OSCC), n = 20] 1061.7 1978.8 (control, 20)....
<b>PURPOSE</b> Multiple cancer screening tests have been advocated for the general population; however, clinicians and patients are not always well-informed of burdens. We sought to determine cumulative risk a false-positive result resulting diagnostic procedure an individual participating in multimodal program. <b>METHODS</b> Data were analyzed from intervention arm ongoing Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial, randomized controlled trial effects prostate, lung,...