A5100410145- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Analytical Chemistry and Sensors
- Mycobacterium research and diagnosis
- Lung Cancer Research Studies
- Microfluidic and Bio-sensing Technologies
- Cancer Cells and Metastasis
- Molecular Junctions and Nanostructures
- Chemical Synthesis and Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Single-cell and spatial transcriptomics
- Electrochemical Analysis and Applications
- Nanopore and Nanochannel Transport Studies
- Microbial Inactivation Methods
- Advanced Biosensing Techniques and Applications
- RNA Research and Splicing
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- 14-3-3 protein interactions
Southern Medical University
2015-2024
Chinese Academy of Agricultural Sciences
2024
Gansu Provincial Hospital
2022-2024
Chongqing University
2023-2024
Oil Crops Research Institute
2024
Chongqing Three Gorges University
2024
Guangzhou Medical University
2015-2023
Guangzhou First People's Hospital
2015-2023
South China University of Technology
2018-2023
University of California, Los Angeles
2009-2023
Recent studies have demonstrated that discriminatory salivary biomarkers can be readily detected upon the development of systemic diseases such as pancreatic cancer, breast lung and ovarian cancer. However, utility for detection has been undermined due to absence biological mechanistic rationale why distal from oral cavity would lead in saliva. Here, we examine hypothesis tumor-derived exosomes are mechanistically involved cancer-discriminatory transcriptomic biomarkers. We first developed a...
Abstract The long non-coding RNA, plasmacytoma variant translocation 1 (PVT1), is highly expressed in a variety of tumors, and believed to be potential oncogene. However, the role mechanism action PVT1 carcinogenesis progression nasopharyngeal carcinomas (NPCs) remains unclear. In this study, for first time, we have discovered that shows higher expression NPCs than normal epithelial tissue, patients with who show worse progression-free overall survivals. Additionally, observed proliferation...
Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly non-small cell lung carcinoma (NSCLC). Mutations identified EGFR predict sensitivity to EGFR-targeted therapy. Detection these mutations mainly based on tissue biopsy, which invasive, expensive, and time consuming.Noninvasive, real-time, inexpensive detection monitoring patients with NSCLC highly desirable.We developed a novel core technology, electric field-induced release...
Epstein-Barr virus (EBV) infection is causatively related to a variety of human cancers, including nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV encodes 44 mature miRNAs, number which have been proven promote carcinogenesis by targeting host genes or self-viral genes. However, in this study, we found that an EBV-encoded microRNA, termed EBV-miR-BART6-3p, inhibited EBV-associated cell migration invasion NPC GC reversing the epithelial-mesenchymal transition (EMT) process. Using...
// Jianjun Yu 1, * , Yan Liu 2, Zhaojian Gong 3, 4 Shanshan Zhang 3 Can Guo 2 Xiayu Li 5 Yanyan Tang Liting Yang Yi He Fang Wei Yumin Wang Qianjin Liao Wenling Xiaoling Yong 6 Guiyuan Xiong Zhaoyang Zeng 1 Department of Head and Neck Surgery, Hunan Cancer Hospital The Affiliated Xiangya School Medicine, Central South University, Changsha, Hunan, China Key Laboratory Carcinogenesis the Chinese Ministry Health, Research Institute, Invasion Education, Hospital, Stomatolog, Second Nonresolving...
For sensors detecting immobilized biomarkers, the interface between surface and fluid medium plays an important role in determining levels of signal noise electrochemical detection process. When protein is directly on metal electrode, denaturation by surface-protein interaction results low activity level. A conducting polymer-based can prevent conformation change alleviate this problem. DNA dendrimer introduced into interfacial film sensor to further improve performance. a nanoscale dendrite...
A robust poly(dimethylsiloxane) (PDMS) surface treatment was utilized for the development of a self-pumping lab-on-a-chip (LOC) to rapidly detect minute quantities toxic substances. One such toxin, botulinum neurotoxin (BoNT), is an extremely lethal substance, which has potential cause hundreds thousands fatalities if as little few grams are released into environment. To prevent outcome, quick (< 45 min) and sensitive detection format needed. We have developed LOC that can sense down 1 pg...
Overexpression of the transcriptional factor Hes1 (hairy and enhancer split-1) has been observed in numerous cancers, but precise roles epithelial-mesenchymal transition (EMT), cancer invasion metastasis remain unknown. Our current study firstly revealed that upregulation a cohort human nasopharyngeal carcinoma (NPC) biopsies is significantly associated with EMT, invasive metastatic phenotypes cancer. In present study, we found overexpression triggered EMT-like cellular marker alterations...
// Fang Wei 1, 6, * , Xiao-Xiang Rong 3, Rao-Ying Xie Li-Ting Jia 5 Hui-Yan Wang 1 Yu-Juan Qin Lin Chen Hong-Fen Shen Xiao-Lin Jie Yang Sheng Wei-Chao Hao Yan Sheng-Jun Xiao Hui-Rong Zhou Tao-Yan Yu-Shuang Sun 4 Kai-Tai Yao Dong 2 Cancer Research Institute, Southern Medical University, Guangzhou 510515, China Institute of Comparative Medicine & Laboratory Animal Center, 3 Department Oncology, Nanfang Hospital, Children's Hospital Boston, Harvard School, Massachusetts 02115, USA...
Epstein-Barr virus (EBV) is a tumorigenic that can cause various human malignancies such as nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV encodes 44 mature micro (mi)RNAs, mostly exhibiting oncogenic properties promoting progression. However, we have previously found one EBV-encoded miRNA, namely EBV-miR-BART6-3p, acts tumor suppressor by inhibiting metastasis invasion. Here, report EBV-miR-BART6-3p inhibits the proliferation of EBV-associated cancers, NPC, GC, targeting...
Abstract Background In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, mechanisms underlying resistance are still poorly understood. this study, we investigated roles cold‑inducible RNA binding protein (Cirbp) in regulating and nasopharyngeal carcinoma (NPC). Methods CCK-8 assay, colony formation tumor sphere qRT-PCR, Western blot were employed to examine effects (HT), HT + oridonin(Ori) or radiotherapy...
Abstract Fibroblast growth factor receptor‐like 1 (FGFRL1), a member of the FGFR family, has been demonstrated to play important roles in various cancers. However, role FGFRL1 small‐cell lung cancer (SCLC) remains unclear. Our study aimed investigate chemoresistance SCLC and elucidate possible molecular mechanism. We found that levels are significantly up‐regulated multidrug‐resistant cells (H69AR H446DDP) compared with sensitive parental (H69 H446). In addition, clinical samples showed was...
DNA-compatible diversity-oriented synthesis of nitrogen-containing heterocycles via the in situ conversion primary amines into versatile isothiocyanates intermediates.