A5080732334- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Crystallography and molecular interactions
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
- Metal-Organic Frameworks: Synthesis and Applications
- Immune Cell Function and Interaction
- Synthetic Organic Chemistry Methods
- Assisted Reproductive Technology and Twin Pregnancy
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Reproductive Biology and Fertility
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- Single-cell and spatial transcriptomics
- RNA and protein synthesis mechanisms
Central South University
2014-2024
Xiangya Hospital Central South University
2014-2024
Jiangnan University
2023-2024
Huazhong University of Science and Technology
2022-2024
Women's Hospital
2024
First Affiliated Hospital of Wenzhou Medical University
2022
Center for Life Sciences
2018-2022
Tsinghua University
2017-2022
Hunan Cancer Hospital
2018-2022
Wenzhou Medical University
2022
Epstein-Barr virus (EBV) infection is an established cause of nasopharyngeal carcinoma (NPC) and involved in a variety malignant phenotypes, including tumor immune escape. EBV can encode circular RNAs (circRNA), however, little known regarding the biological functions these circRNAs NPC. In this study, EBV-encoded circBART2.2 was found to be highly expressed NPC where it upregulated PD-L1 expression inhibited T-cell function vitro vivo. promoted transcription by binding helicase domain RIG-I...
Abstract Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and closely related to occurrence development of nasopharyngeal carcinoma (NPC), gastric (GC), several lymphomas. PD-L1 expression elevated in EBV-positive NPC GC tissues; however, specific mechanisms underlying EBV-dependent promotion induce immune escape warrant clarification. EBV encodes 44 mature miRNAs. In this study, we find that EBV-miR-BART11 EBV-miR-BART17-3p upregulate EBV-associated GC....
Abstract The long non-coding RNA, plasmacytoma variant translocation 1 (PVT1), is highly expressed in a variety of tumors, and believed to be potential oncogene. However, the role mechanism action PVT1 carcinogenesis progression nasopharyngeal carcinomas (NPCs) remains unclear. In this study, for first time, we have discovered that shows higher expression NPCs than normal epithelial tissue, patients with who show worse progression-free overall survivals. Additionally, observed proliferation...
Actin filament-associated protein 1 antisense RNA (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic lncRNA promote NPC metastasis. The AFAP1-AS1, miR-423-5p, FOSL2 was investigated vitro vivo. Bioinformatics analysis luciferase activity assays were used interaction between FOSL2....
Nasopharyngeal carcinoma (NPC) carries a high potential for metastasis and immune escape, with great risk of relapse after primary treatment. Through analysis whole genome expression profiling data in NPC samples, we found that the long non-coding RNA (lncRNA), actin filament-associated protein 1 antisense (AFAP1-AS1), is significantly correlated escape marker programmed death (PD-1). We therefore assessed AFAP1-AS1 PD-1 cohort 96 paraffin-embedded samples confirmed are co-expressed...
Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, post-transcriptional levels. Long are turn regulated other genes, forming a complex regulatory network. The regulation networks between p53 tumor suppressor these nasopharyngeal carcinoma remains unclear. aims this study were to investigate roles TP53 gene RNA expression profiles function TP53-regulated...
Abstract Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNA s act as important regulators in at the transcriptional posttranscriptional levels. The circular circ MAN 1A2 is highly expressed nasopharyngeal carcinoma according our previous sequencing data; however, expression functions still obscure. Therefore, this study, we evaluated sera patients with other malignant tumors analyzed its correlations clinical features values. levels...
Abstract Background Circular RNAs (circRNAs) are widely expressed in human cells and closely associated with cancer development. However, they have rarely been investigated the context of nasopharyngeal carcinoma (NPC). Methods We screened a new circRNA, circRNF13 , NPC using next-generation sequencing mRNA. Reverse transcription polymerase chain reaction RNA fluorescence situ hybridization were used to detect expression 12 non-tumor epithelial (NPE) tissues 36 samples. Cell proliferation...
Abstract Actin filament associated protein 1 antisense RNA (named AFAP1-AS1) is a long non-coding and overexpressed in many cancers. This study aimed to identify the role mechanism of AFAP1-AS1 lung cancer. The expression was firstly assessed 187 paraffin-embedded cancer 36 normal epithelial tissues by situ hybridization. migration invasion abilities were investigated cells. To uncover molecular about function cancer, we screened proteins that interact with pull down mass spectrometry...
Bactericidal/Permeability-increasing-fold-containing family B member 1 (BPIFB1, previously termed LPLUNC1) is highly expressed in the nasopharynx, significantly downregulated nasopharyngeal carcinoma (NPC), and associated with prognosis NPC patients. Because metastasis represents primary cause of NPC-related death, we explored role BPIFB1 migration invasion. The was investigated vitro vivo. A co-immunoprecipitation assay coupled mass spectrometry used to identify BPIFB1-binding proteins....
Epstein-Barr virus (EBV) infection and chronic inflammation are closely associated with the development progression of nasopharyngeal carcinoma (NPC) gastric cancer (GC), infiltration inflammatory cells, including tumor-associated macrophages (TAMs), is often observed in these cancers. EBV encodes 44 mature micro RNAs (miRNAs), but roles only a few EBV-encoded miRNA targets known development, here, our aim was to elucidate effects EBV-miR-BART11 on FOXP1 expression, potential involvement...
Long non-coding RNAs (lncRNAs) are dysregulated in various cancers. However, the clinical relevance and functional roles of AFAP1-AS1 colon cancer (CC) have not been clarified. We analyzed lncRNA expression patterns Gene Expression Omnibus (GEO) datasets Cancer Genome Atlas (TCGA) RNA-seq datasets, found that level was significantly elevated CC tissues. High levels were associated with poor disease-free survival overall patients. In vitro experiments demonstrated knockdown inhibited cell...