A5029461308- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Alkaloids: synthesis and pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Berberine and alkaloids research
- Protein Degradation and Inhibitors
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Acute Myeloid Leukemia Research
- Plant tissue culture and regeneration
- Chromatin Remodeling and Cancer
China Medical University
2022-2025
Universiti Sains Malaysia
2016-2025
East China University of Science and Technology
2025
Guangzhou Medical University
2025
Capital Medical University
2025
Quanzhou Normal University
2025
Taizhou University
2023-2025
University of South Alabama
2012-2024
Nanchang University
2024
Qiqihar University
2024
Non-insulin-dependent diabetes mellitus (NIDDM) is a major cause of end-stage renal disease. However, the course and determinants failure in this type have not been clearly defined.We studied glomerular function at intervals 6 to 12 months for 4 years 194 Pima Indians selected represent different stages development progression diabetic Initially, 31 subjects had normal glucose tolerance, 29 impaired 30 newly diagnosed diabetes, 104 five or more; these 104, 20 albumin excretion, 50...
Paclitaxel (Taxol) is an effective chemotherapeutic agent for treatment of cancer patients. Despite impressive initial clinical responses, the majority patients eventually develop some degree resistance to Taxol-based therapy. The mechanisms underlying cells Taxol are not fully understood. MicroRNA (miRNA) has emerged play important roles in tumorigenesis and drug resistance. However, interaction between development miRNA been previously explored. In this study we utilized a array compare...
Abstract Background Taxol is one of the most effective chemotherapeutic agents for treatment patients with breast cancer. Despite impressive clinical responses initially, majority eventually develop resistance to Taxol. Lactate dehydrogenase-A (LDH-A) predominant isoforms LDH expressed in tissue, which controls conversion pyruvate lactate and plays an important role glucose metabolism. In this study we investigated LDH-A mediating human cancer cells. Results Taxol-resistant subclones,...
Trastuzumab shows remarkable efficacy in treatment of ErbB2-positive breast cancers when used alone or combination with other chemotherapeutics. However, acquired resistance develops most treated patients, necessitating alternate strategies. Increased aerobic glycolysis is a hallmark cancer and inhibition may offer promising strategy to preferentially kill cells. In this study, we investigated the antitumor effects trastuzumab inhibitors cancer. We found that inhibits via downregulation heat...
Abstract The Akt/mammalian target of rapamycin (mTOR)/4E-BP1 pathway is considered to be a central regulator protein synthesis, involving the regulation cell proliferation, differentiation, and survival. inhibitors mTOR as anticancer reagents are undergoing active evaluation in various malignancies including breast cancer. However, activation status Akt/mTOR/4E-BP1 its potential roles cancers remain unknown. Thus, we examined 165 invasive with specific antibodies for phosphorylation Akt,...
Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis or the Warburg effect, and resist matrix detachment-induced apoptosis, which is called anoikis, barrier to metastasis. It remains largely unclear whether tumor influences anoikis Here we show that when detached from matrix, untransformed mammary epithelial undergo metabolic reprogramming markedly upregulating pyruvate dehydrogenase (PDH) kinase 4 (PDK4) through estrogen-related receptor gamma...
Abstract ErbB2 overexpression in breast tumors results increased metastasis and angiogenesis reduced survival. To study signaling mechanisms angiogenesis, we did a spontaneous assay using MDA-MB-435 human cancer cells stably transfected with constitutively active kinase (V659E), kinase-dead mutant of (K753M), or vector control (neo). Mice injected V659E had incidence tumor microvessel density than mice K753M control. Increased vivo from the transfectants paralleled angiogenic potential...
// Shruti Desai 1 , Minming Ding 2 Bin Wang 3 Zhimin Lu 4 Qi Zhao 5 Kenna Shaw 6 W.K. Alfred Yung John N. Weinstein 7 Ming Tan and Jun Yao Mitchell Cancer Institute, Departments of Cell Biology Neuroscience, University South Alabama, Mobile, USA Division Biostatistics, School Public Health, The Texas – Houston Health Science Center, Houston, Department Genetics, M. D. Anderson Neuro-Oncology, Ludwig Collaborative Laboratory, Neurosurgery, Johns Hopkins University, 1550 Orleans Street,...